Inhibitory Properties of AntitumorProstaglandins JSiBA against Topoisomerases Keitarou SuzuKi

Prostaglandins (PGs) haying antitumor activity such as Ai2ti4-PGJ2, Ai2-PGJ2, PGA2 and PGAi strongly inhibited topoisomerase II (topo II) from human placenta, the potential order of inhibitory actiyity of the PGs resembling that of the antitumor activity. PGs having no antitumor actiyity did not inhibit topo II. Ai2,i4PGJz to be a potent inhibitor shuwed inhibitiulls tu some extent against topoIfrom wheat germ, NIH3T3 and calf thymus gland, and showed no inhibition against the enzymes from Vero, A549, HeLa and COLO 201cells.Ai2,i4-PGJ2differentiallyinhibitedtopoIfrom different sources. Ai2,i4-PGJ2 was a topo inhibitor of the ¢ leavable complex-nonforming type without DNA inter-

[1]  Taketoshi,et al.  Antitumor Activity of A7-Prostaglandin AI and A12-Prostaglandin J2 in Vitro and in Vivo1 , 2006 .

[2]  M. Uyeda,et al.  Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. , 2001, Journal of natural products.

[3]  H. Kai,et al.  Inhibition of Topoisomerases by Fatty Acids , 2000, Journal of enzyme inhibition.

[4]  M. Yamaizumi,et al.  Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. III. Inhibitory properties. , 1999, The Journal of antibiotics.

[5]  M. Uyeda,et al.  Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. I. Taxonomy, fermentation, isolation and biological activities. , 1998, The Journal of antibiotics.

[6]  M. Uyeda,et al.  Topostatin, a novel inhibitor of Topoisomerases I and II produced by Thermomonospora alba strain No. 1520. II. Physico-chemical properties and structure elucidation. , 1998, The Journal of antibiotics.

[7]  N. Kojima,et al.  CJ-12,373, a novel topoisomerase II inhibitor: fermentation, isolation, structure elucidation and biological activities. , 1998, The Journal of antibiotics.

[8]  T. Siddique,et al.  Inhibition of DNA topoisomerases by microbial inhibitors. , 1998, Journal of enzyme inhibition.

[9]  T. Siddique,et al.  Macrostatin, a novel macromolecular inhibitor of topoisomerases produced by Streptomyces avermitilis no. C-127. , 1998, Journal of enzyme inhibition.

[10]  M. Uyeda,et al.  Inhibition of topoisomerases by antitumor prostaglandins. , 1998, Bioscience, biotechnology, and biochemistry.

[11]  T. Ishikawa,et al.  Chemical Implications for Antitumor and Antiviral Prostaglandins: Reaction of Δ7-Prostaglandin A1 and Prostaglandin A1 Methyl Esters with Thiols , 1997 .

[12]  A. Rossi,et al.  Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[13]  K. Ochiai,et al.  Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification. , 1995, The Journal of antibiotics.

[14]  S. Tanida,et al.  TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I. , 1994, The Journal of antibiotics.

[15]  A. Maxwell.  The interaction between coumarin drugs and DNA gyrase , 1993, Molecular microbiology.

[16]  T. Andoh,et al.  Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors. , 1991, Cancer research.

[17]  H. Nakano,et al.  Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus. , 1991, Biochemistry.

[18]  Katsutoshi Takahashi,et al.  Human ovarian cancer cell lines resistant to cisplatin, doxorubicin, and l-phenylalanine mustard are sensitive to Δ7-prostaglandin Δ1 and Δ12-prostaglandin J2 , 1991 .

[19]  L. Liu,et al.  Topoisomerase-targeting antitumor drugs. , 1989, Biochimica et biophysica acta.

[20]  W. Ross,et al.  DNA binding by epipodophyllotoxins and N-acyl anthracyclines: implications for mechanism of topoisomerase II inhibition. , 1988, Molecular pharmacology.

[21]  S. Narumiya,et al.  Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells. , 1988, The Journal of pharmacology and experimental therapeutics.

[22]  K. Chan,et al.  A direct colorimetric assay for Ca2+ -stimulated ATPase activity. , 1986, Analytical biochemistry.

[23]  L. Liu,et al.  Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. , 1984, Science.

[24]  L. Liu,et al.  Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[25]  L. Liu,et al.  Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. , 1984, The Journal of biological chemistry.

[26]  W. Denny,et al.  Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring , 1981 .