Clinical Characteristics of Nocardia Infection in Patients with Rheumatic Diseases

Although Nocardiosis has considerable recurrence and mortality rates, characteristics and risk factors of Nocardia infection have not been assessed in patients with rheumatic diseases. Here, we examined the characteristics and risk factors of Nocardia infection in rheumatic disease patients in our hospital. Ten rheumatic disease patients who developed Nocardia infection were identified by retrospectively reviewing the medical records. Possible predisposing factors for Nocardia infection were high-dose glucocorticoid treatment, concomitant use of immunosuppressants, preexisting pulmonary diseases, and diabetes mellitus. All patients had pulmonary Nocardiosis, and six of them had disseminated Nocardiosis when their pulmonary lesions were identified.

[1]  M. Yigla,et al.  Clinical Spectrum and Outcome of Nocardia Infection: Experience of 15-Year Period From a Single Tertiary Medical Center , 2012, The American journal of the medical sciences.

[2]  F. Tubach,et al.  Risk of herpes zoster in patients receiving anti-TNF-α in the prospective French RATIO registry. , 2012, The Journal of investigative dermatology.

[3]  J. Garbino,et al.  Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center , 2010, Infection.

[4]  M. Ameen,et al.  Efficacy of imipenem therapy for Nocardia actinomycetomas refractory to sulfonamides. , 2010, Journal of the American Academy of Dermatology.

[5]  R. Salata,et al.  Infectious Complications Associated with Monoclonal Antibodies and Related Small Molecules , 2009, Clinical Microbiology Reviews.

[6]  D. Paterson,et al.  Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case-control study. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  R. Martínez Tomás,et al.  Pulmonary nocardiosis: Risk factors and outcomes , 2007, Respirology.

[8]  L. Espinoza,et al.  Nocardia brain abscesses in a male patient with SLE: successful outcome despite delay in diagnosis , 2007, Clinical Rheumatology.

[9]  L. Espinoza,et al.  Nocardia species infections in a large county hospital in Miami: 6 years experience. , 2007, The Journal of infection.

[10]  R. Cervera,et al.  Infections in systemic lupus erythematosus: a prospective and controlled study of 110 patients , 2006, Lupus.

[11]  R. Wallace,,et al.  Clinical and Laboratory Features of the Nocardia spp. Based on Current Molecular Taxonomy , 2006, Clinical Microbiology Reviews.

[12]  S. Apostolakis,et al.  Lymphocutaneous Nocardiosis in a Lymphopenic Breast Cancer Patient under Treatment with Docetaxel , 2005, The Breast Journal.

[13]  R. Kroppenstedt,et al.  Nocardia arthritidis sp. nov., a New Pathogen Isolated from a Patient with Rheumatoid Arthritis in Japan , 2004, Journal of Clinical Microbiology.

[14]  M. Saubolle,et al.  Nocardiosis , 2003, Journal of Clinical Microbiology.

[15]  M. Saubolle,et al.  Nocardiosis , 1972, The Australasian journal of dermatology.

[16]  A. Prasse,et al.  Infectious CNS disease as a differential diagnosis in systemic rheumatic diseases: three case reports and a review of the literature , 2003, Annals of the rheumatic diseases.

[17]  J. Dummer,et al.  Nocardial infections in bone marrow transplant recipients. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[18]  M. Fischl,et al.  Nocardiosis in 30 patients with advanced human immunodeficiency virus infection: clinical features and outcome. , 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[19]  G. Bodey,et al.  Nocardial infection in patients with neoplastic disease. , 1989, Reviews of infectious diseases.

[20]  Nina Singh,et al.  Infections in solid organ transplant recipients. , 2000, Current opinion in infectious diseases.