An Extended Minimization Method to Assure Similar Means of Continuous Prognostic Variables between Treatment Groups
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We propose a new treatment allocation method that assures similar means of continuous prognostic variables between treatment groups in randomized clinical trials. This method is an extension of the minimization method proposed by Pocock and Simon to continuous variables case. There are several measures to be minimized simultaneously, and we make a linear combination comprised of these weighted measures. The sizes of these weights of measures must be determined before implementation of this method. We give some examples to illustrate the achievement of this method and a guideline for the weights.
[1] F. del Greco,et al. Maintenance dialysis for diabetic nephropathy with uremia. , 1975, Journal of chronic diseases.
[2] M Zelen,et al. The randomization and stratification of patients to clinical trials. , 1974, Journal of chronic diseases.
[3] S. Pocock,et al. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. , 1975, Biometrics.