The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1.

[1]  C. Larsen,et al.  A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease. , 2006, Journal of autoimmunity.

[2]  Alissa C. Baker,et al.  Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes. , 2006, Journal of autoimmunity.

[3]  P. Fain,et al.  Conserved extended haplotypes discriminate HLA-DR3-homozygous Basque patients with type 1 diabetes mellitus and celiac disease , 2006, Genes and Immunity.

[4]  L. Zhao,et al.  Toward understanding MHC disease associations: partial resequencing of 46 distinct HLA haplotypes. , 2006, Genomics.

[5]  M. Rewers,et al.  Multi-SNP Analysis of MHC Region , 2006, Diabetes.

[6]  C. Larsen,et al.  The genetics of HLA-associated disease. , 2004, Current opinion in immunology.

[7]  M. A. Kelly,et al.  Sequencing of the Second Exon of the MHC Class II DQ6 Alleles in Patients with Type 1 Diabetes , 2002, Autoimmunity.

[8]  E. Yunis,et al.  A Simple Estimate of the General Population Frequency of the MHC Susceptibility Gene for Autoimmune Polygenic Disease , 2000, Experimental and Clinical Immunogenetics.

[9]  H. Erlich,et al.  Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes. , 1999, The Journal of clinical endocrinology and metabolism.

[10]  A. Lew,et al.  The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells. , 1997, Journal of immunology.

[11]  M. Barnardo,et al.  Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). , 1995, Tissue antigens.

[12]  A. Lew,et al.  Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer. , 1994, Human immunology.

[13]  G. Nepom,et al.  Conservation of the HLA-DQB2 locus in nonhuman primates. , 1992, Journal of immunology.

[14]  M. Sheehy,et al.  The cryptic HLA-DQA2 ("DX alpha") gene is expressed in human B cell lines. , 1991, Journal of immunology.

[15]  H. Erlich,et al.  Implication of Specific DQB1 Alleles in Genetic Susceptibility and Resistance by Identification of IDDM Siblings With Novel HLA-DQB1 Allele and Unusual DR2 and DR1 Haplotypes , 1991, Diabetes.

[16]  J. R. Rowe,et al.  HLA-DQA2 (DX alpha) polymorphism and insulin dependent diabetes. , 1990, Human immunology.

[17]  J. Strominger,et al.  Molecular organization of the DQ subregion (DO-DX-DV-DQ) of the human MHC and its evolutionary implications. , 1988, Journal of immunology.

[18]  C. Auffray,et al.  Exuberant restriction fragment length polymorphism associated with the DQ alpha-chain gene and the DX alpha-chain gene. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[19]  K. Gabbay,et al.  Extended major histocompatibility complex haplotypes in type I diabetes mellitus. , 1984, The Journal of clinical investigation.

[20]  R. Spielman,et al.  Six HLA-D region alpha-chain genes on human chromosome 6: polymorphisms and associations of DC alpha-related sequences with DR types. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[21]  G. Thomson.  A two locus model for juvenile diabetes , 1980, Annals of human genetics.

[22]  P. Rubinstein,et al.  Genetics of juvenile diabetes mellitus. A recessive gene closely linked to HLA D and with 50 per cent penetrance. , 1977, The New England journal of medicine.

[23]  H. Erlich,et al.  Implication of Specific DQB 1 Alleles in Genetic Susceptibility and Resistance by Identification of IDDM Siblings With Novel HLA-DQB 1 Allele and Unusual DR 2 and DR 1 Haplotypes , 2010 .

[24]  C. Larsen,et al.  The haplotype structure of the human major histocompatibility complex. , 2006, Human immunology.

[25]  J. Trowsdale,et al.  Mapping and nucleotide sequence of a newHLA class II light chain gene,DQB3 , 2006, Immunogenetics.

[26]  P. Concannon,et al.  The genetics of type 1 diabetes: lessons learned and future challenges. , 2005, Journal of autoimmunity.

[27]  Kara Hunter,et al.  Type 1 diabetes genes and pathways shared by humans and NOD mice. , 2005, Journal of autoimmunity.

[28]  C. Alper,et al.  BF types and the mode of inheritance of insulin-dependent diabetes mellitus (IDDM) , 2005, Immunogenetics.

[29]  G. Hitman,et al.  A DR3-related DXα gene polymorphism strongly associates with insulin-dependent diabetes mellitus , 2004, Immunogenetics.

[30]  B. Mach,et al.  Remarkable sequence conservation of theHLA-DQB2 locus (DXβ) within the highly polymorphicDQ subregion of the human MHC , 2004, Immunogenetics.

[31]  C. Auffray,et al.  Structure and expression of HLA-DQα and -DXα genes: interallelic alternate splicing of the HLA-DQα gene and functional splicing of the HLA-DXα gene using a retroviral vector , 2004, Immunogenetics.

[32]  P. Bingley,et al.  Restriction fragment length polymorphism analysis of HLA haplotypes in families with type I diabetes mellitus. , 1990, Tissue antigens.

[33]  S. Rich.  A combined segregation and linkage analysis of insulin-dependent diabetes mellitus. , 1986, Genetic epidemiology. Supplement.

[34]  C. Auffray,et al.  Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. , 1984, Nature.

[35]  C. Auffray,et al.  Isotypic and allotypic variation of human class II histocompatibility antigen α-chain genes , 1984, Nature.

[36]  E. Yunis,et al.  Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man. , 1983, Proceedings of the National Academy of Sciences of the United States of America.