Effect of indoor house dust mite concentration on canine atopic dermatitis

Introduction House dust mites (HDM) are regarded as essential environmental allergens not only in human, but also in canine atopic dermatitis (CAD), however, there are only a few studies on the influence of indoor HDM concentration on the disease. Methods Our study analyzed the correlation between the indoor HDM concentration, the severity of CAD, and the residential environments in client-owned 35 AD and 13 healthy dogs. We measured the extent of CAD and severity index-04 (CADESI-04), pruritus visual analog scale (PVAS), and transepidermal water loss (TEWL), indoor relative humidity (RH) and analyzed the residential environment questionnaires to evaluate AD severity. Results The Der f 1 concentration had an inverse association with TEWL, and no association with CADESI-04 and PVAS. The Der f 1 concentration was significantly high in the group living near the green area and 40% or higher RH. Discussion Our results suggest two possibilities: (1) Living around green areas and maintaining an appropriate indoor climate may help to improve CAD clinical symptoms. (2) The HDM may contain endotoxin and when present in high concentrations in CAD, they play a preventive role by enhancing the skin barrier function. Further studies with a larger number of dogs may help further elucidate an association between CAD and Der f 1.

[1]  Eunsoo Kim,et al.  Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma , 2020, Frontiers in Immunology.

[2]  J. Cappelle,et al.  A moisturizer formulated with glycerol and propylene glycol accelerates the recovery of skin barrier function after experimental disruption in dogs , 2020, Veterinary dermatology.

[3]  J. Min,et al.  Association between green areas and allergic disease in Korean adults: a cross-sectional study , 2020, Annals of occupational and environmental medicine.

[4]  N. Acevedo,et al.  House Dust Mite Allergy Under Changing Environments , 2019, Allergy, asthma & immunology research.

[5]  D. Santoro.  Therapies in Canine Atopic Dermatitis: An Update. , 2019, The Veterinary clinics of North America. Small animal practice.

[6]  Patricia M. Valenzuela,et al.  Is there an association between indoor allergens and the severity of atopic dermatitis? , 2018, International journal of dermatology.

[7]  J. Kopecký,et al.  Population and Culture Age Influence the Microbiome Profiles of House Dust Mites , 2018, Microbial Ecology.

[8]  Li Dong,et al.  The influence of the spatial characteristics of urban green space on the urban heat island effect in Suzhou Industrial Park , 2018, Sustainable Cities and Society.

[9]  E. Ha,et al.  Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure , 2018, International journal of environmental research and public health.

[10]  S. Andrušaitytė,et al.  Associations between neighbourhood greenness and asthma in preschool children in Kaunas, Lithuania: a case–control study , 2016, BMJ Open.

[11]  Allan Linneberg,et al.  Respiratory allergy caused by house dust mites: What do we really know? , 2015, The Journal of allergy and clinical immunology.

[12]  D. Santoro,et al.  Review: Pathogenesis of canine atopic dermatitis: skin barrier and host-micro-organism interaction. , 2015, Veterinary dermatology.

[13]  C. Hong,et al.  Changes in Allergen Sensitization Over The Last 30 Years in Korea Respiratory Allergic Patients: A Single-Center , 2014, Allergy, asthma & immunology research.

[14]  Tim Nuttall,et al.  Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. , 2014, Veterinary dermatology.

[15]  F. Chew,et al.  Allergic airway diseases in a tropical urban environment are driven by dominant mono-specific sensitization against house dust mites , 2014, Allergy.

[16]  Youngshin Han,et al.  The Indoor Level of House Dust Mite Allergen Is Associated with Severity of Atopic Dermatitis in Children , 2013, Journal of Korean medical science.

[17]  C. Hong,et al.  House Dust Mite Allergy in Korea: The Most Important Inhalant Allergen in Current and Future , 2012, Allergy, asthma & immunology research.

[18]  R. Marsella,et al.  Transepidermal water loss in healthy and atopic dogs, treated and untreated: a comparative preliminary study. , 2012, Veterinary dermatology.

[19]  B. Brunekreef,et al.  Inverse association between endotoxin exposure and canine atopic dermatitis. , 2011, Veterinary journal.

[20]  J. Tsai,et al.  Prevalence of Tyrophagus putrescentiae Hypersensitivity in Subjects over 70 Years of Age in a Veterans’ Nursing Home in Taiwan , 2010, International Archives of Allergy and Immunology.

[21]  C. Favrot,et al.  A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. , 2010, Veterinary dermatology.

[22]  M. Hogan,et al.  Effect of evaporative coolers on skin test reactivity to dust mites and molds in a desert environment. , 2009, Allergy and asthma proceedings.

[23]  Taeho Oh,et al.  Measurement of transepidermal water loss from clipped and unclipped anatomical sites on the dog. , 2009, Australian veterinary journal.

[24]  K. Nishifuji,et al.  Transepidermal water loss (TEWL) reflects skin barrier function of dog. , 2008, The Journal of veterinary medical science.

[25]  J. Rybnicek,et al.  Development of an owner-assessed scale to measure the severity of pruritus in dogs. , 2007, Veterinary dermatology.

[26]  J. Celedón,et al.  Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood. , 2007, The Journal of allergy and clinical immunology.

[27]  N. Thomson,et al.  House dust mite control measures in the treatment of asthma , 2006, Therapeutics and clinical risk management.

[28]  Deborah Jarvis,et al.  Distribution and determinants of house dust mite allergens in Europe: the European Community Respiratory Health Survey II. , 2006, The Journal of allergy and clinical immunology.

[29]  T. Nuttall,et al.  House dust and forage mite allergens and their role in human and canine atopic dermatitis. , 2006, Veterinary dermatology.

[30]  J. Ring,et al.  Current eczema in children is related to Der f 1 exposure but not to Der p 1 exposure , 2006, The British journal of dermatology.

[31]  N. Lukacs,et al.  Interleukin-12-independent down-modulation of cockroach antigen-induced asthma in mice by intranasal exposure to bacterial lipopolysaccharide. , 2003, The American journal of pathology.

[32]  Kim Bottomly,et al.  Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen , 2002, The Journal of experimental medicine.

[33]  Motoji Takahashi,et al.  Effect of exposure of human skin to a dry environment , 2002, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[34]  D. Nowak,et al.  Environmental exposure to endotoxin and its relation to asthma in school-age children. , 2002, The New England journal of medicine.

[35]  E. Bensignor,et al.  Sensitivity patterns to house dust mites and forage mites in atopic dogs: 150 cases. , 2002, Veterinary dermatology.

[36]  T. Olivry,et al.  The ACVD task force on canine atopic dermatitis (IX): the controversy surrounding the route of allergen challenge in canine atopic dermatitis. , 2001, Veterinary immunology and immunopathology.

[37]  M. Masi,et al.  Effect of house dust mite avoidance measures in children with atopic dermatitis , 2000 .

[38]  M. Denda,et al.  Dry condition affects desquamation of stratum corneum in vivo. , 1998, Journal of dermatological science.

[39]  P. Elias,et al.  Exposure to a dry environment enhances epidermal permeability barrier function. , 1998, The Journal of investigative dermatology.

[40]  Uter,et al.  An epidemiological study of the influence of season (cold and dry air) on the occurrence of irritant skin changes of the hands , 1998, The British journal of dermatology.

[41]  A. Halbert,et al.  Atopic dermatitis: is it an allergic disease? , 1995, Journal of the American Academy of Dermatology.

[42]  S. Schraub,et al.  Sensitization to mite allergens is a risk factor for early and late onset of asthma and for persistence of asthmatic signs in children. , 1995, The Journal of allergy and clinical immunology.

[43]  S. Schraub,et al.  Mite allergen exposure is a risk for the incidence of specific sensitization. , 1994, The Journal of allergy and clinical immunology.

[44]  M. Colloff,et al.  Exposure to house dust mites in homes of people with atopic dermatitis , 1992, The British journal of dermatology.

[45]  E. Fernández‐Caldas,et al.  Mite allergens , 2005, Current Allergy and Asthma Reports.

[46]  J. Jaakkola,et al.  The effect of air humidification on symptoms and perception of indoor air quality in office workers: a six-period cross-over trial. , 1992, Archives of environmental health.