Immunoreactive trypsin and the prenatal diagnosis of cystic fibrosis

Immunoreactive trypsin (IRT) was measured by radio‐immunoassay in a series of amniotic fluids obtained at between 15 and 19 weeks from pregnancies with a 1‐in‐4 risk of fetal cystic fibrosis. IRT concentrations were significantly depressed in nine affected pregnancies, but the degree of overlap with the normal range was too great for this to be useful in early prenatal diagnosis. Furthermore, in one fetus, presumed to have cystic fibrosis, the fetal plasma IRT concentration was within the normal range.

[1]  C. Hayward,et al.  AMNIOTIC FLUID GGTP IN PRENATAL DIAGNOSIS OF CYSTIC FIBROSIS: A WORD OF WARNING , 1983, The Lancet.

[2]  W. Kleijer,et al.  DISACCHARIDASES IN AMNIOTIC FLUID AS POSSIBLE PRENATAL MARKER FOR CYSTIC FIBROSIS , 1983, The Lancet.

[3]  B. Wilcken,et al.  Cystic fibrosis screening by dried blood spot trypsin assay: results in 75,000 newborn infants. , 1983, The Journal of pediatrics.

[4]  C. Gosden,et al.  MICROVILLAR PEPTIDASE ACTIVITY IN AMNIOTIC FLUID: POSSIBLE USE IN THE PRENATAL DIAGNOSIS OF CYSTIC FIBROSIS , 1983, The Lancet.

[5]  C. Hayward,et al.  Prenatal diagnosis of cystic fibrosis by methylumbelliferylguanidinobenzoate protease titration in amniotic fluid , 1983, Prenatal diagnosis.

[6]  H. Punnett,et al.  IMPORTANCE OF PATHOLOGICAL EXAMINATION OF PRODUCTS OF CONCEPTION WHICH ARE DELIVERED AFTER PRENATAL SCREENING PROCEDURES , 1982, The Lancet.

[7]  B. Rosenstein,et al.  4-METHYLUMBELLIFERYLGUANIDINOBENZOATE REACTIVE PLASMA "PROTEASE" IN CYSTIC FIBROSIS IS ALBUMIN , 1982, The Lancet.

[8]  D. Abramovich,et al.  Origin and levels of trypsin in amniotic fluid throughout pregnancy , 1982, British journal of obstetrics and gynaecology.

[9]  M. Walsh,et al.  Screening for cystic fibrosis by died blood spot trypsin assay. , 1982, Archives of disease in childhood.

[10]  H. Nadler,et al.  Prenatal detection of cystic fibrosis. , 1981, American journal of obstetrics and gynecology.

[11]  H. Nadler,et al.  PRENATAL DETECTION OF CYSTIC FIBROSIS , 1981, The Lancet.

[12]  D. Hardwick,et al.  Use of a dried blood spot in immunoreactive-trypsin assay for detection of cystic fibrosis in infants. , 1981, Clinical chemistry.

[13]  H. Nadler,et al.  Intrauterine detection of cystic fibrosis. , 1980, Pediatrics.

[14]  A. Milunsky,et al.  Prenatal detection of intestinal obstruction: deficient amniotic fluid disaccharidases in affected fetuses , 1980, Clinical genetics.

[15]  C. Rodeck,et al.  FETOSCOPY GUIDED BY REAL‐TIME ULTRASOUND FOR PURE FETAL BLOOD SAMPLES, FETAL SKIN SAMPLES, AND EXAMINATION OF THE FETUS IN UTERO , 1980, British journal of obstetrics and gynaecology.

[16]  H. Harris,et al.  Origin of the alkaline phosphatases in amniotic fluid. , 1979, American journal of obstetrics and gynecology.

[17]  JeanetteR. Crossle,et al.  DRIED-BLOOD SPOT SCREENING FOR CYSTIC FIBROSIS IN THE NEWBORN , 1979, The Lancet.

[18]  M. Potier,et al.  Developmental patterns of intestinal disaccharidases in human amniotic fluid. , 1978, American journal of obstetrics and gynecology.

[19]  H. Shwachman,et al.  Studies in meconium: disaccharidase activities in meconium from cystic fibrosis patients and controls. , 1975, Pediatrics.