Amelioration of photic injury in rat retina by ascorbic acid: a histopathologic study.

It has been postulated that ascorbic acid may help to protect the retina from oxidative insult by light. To confirm this hypothesis, the authors compared light-damaged retinas of rats with or without ascorbate supplement by morphologic and morphometric studies at different time periods after light exposure. No dramatic morphologic differences were observed in the photoreceptor-retinal pigment epithelium complex between the two groups six hr after light exposure to 200 to 250-foot candles of visible light. Six to 13 days after 24 hr of exposure, the retina of rats that received ascorbate supplement showed significantly less severe damage than the retina of unsupplemented rats. The superior and temporal quadrants of the retina appeared to be most susceptible to the light damage when comparing rats with or without ascorbate supplement. These findings suggested that ascorbate ameliorates the photic injury in rat retina.

[1]  T. Williams,et al.  A Parametric Study of Retinal Light Damage in Albino and Pigmented Rats , 1980 .

[2]  W. L. Howell,et al.  Action spectrum of retinal light-damage in albino rats. , 1983, Investigative ophthalmology & visual science.

[3]  W. Noell.  There are Different Kinds of Retinal Light Damage in the Rat , 1980 .

[4]  D. Kleinbaum,et al.  Applied Regression Analysis and Other Multivariate Methods , 1978 .

[5]  H. Heath,et al.  Biochemical changes in aphakia , 1961 .

[6]  T. Kuwabara,et al.  Retinal recovery from exposure to light. , 1970, American journal of ophthalmology.

[7]  K. Lam,et al.  Ascorbate concentration in tissues from normal and buphthalmic rabbits. , 1982, The Journal of heredity.

[8]  M. Tso,et al.  Reduced and oxidized ascorbates in guinea pig retina under normal and light-exposed conditions. , 1983, Investigative ophthalmology & visual science.

[9]  Santhosh K. P. Kumar,et al.  Light-induced damage to ocular lens cation pump: prevention by vitamin C. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[10]  D. Organisciak,et al.  Ascorbate and glutathione levels in the developing normal and dystrophic rat retina: effect of intense light exposure. , 1984, Current eye research.

[11]  M. Tso,et al.  The protective effect of ascorbate in retinal light damage of rats. , 1985, Investigative ophthalmology & visual science.

[12]  M. Tso,et al.  Distribution of ascorbate in normal primate retina and after photic injury: a biochemical, morphological correlated study. , 1984, Current eye research.

[13]  H. Heath,et al.  Changes in the ascorbic acid and glutathione content of the retinae and adrenals from alloxan-diabetic rats , 1962 .

[14]  W. Noell,et al.  Possible mechanisms of photoreceptor damage by light in mammalian eyes , 1980, Vision Research.