rt-PA Helps Prevent Hemodialysis Catheter Malfunction

Central venous catheters are used for vascular access in patients who are undergoing hemodialysis, but about 50% of catheters fail within 1 year, usually due to thrombosis. Catheter failure is associated with higher incidences of infection, hospitalization, and death, as well as with higher costs. Various agents (locking solutions) are instilled routinely into central venous catheters after …

[1]  W. Winkelmayer Tackling the Achilles' heel of hemodialysis. , 2011, The New England journal of medicine.

[2]  M. Tonelli,et al.  Prevention of dialysis catheter malfunction with recombinant tissue plasminogen activator. , 2011, The New England journal of medicine.