The effect of diltiazem on the cardiovascular response to tracheal intubation

The efficacy of diltiazem in the attenuation of the cardiovascular response to laryngoscopy and tracheal intubation was studied in patients who received 0.2 or 0.3 mg/kg diltiazem 60 seconds before the start of laryngoscopy. These data were compared with a control group who received saline. Each group consisted of 10 patients who had elective surgery. Patients who received saline showed a significant increase in mean arterial pressure and rate pressure product associated with tracheal intubation. These increases after tracheal intubation were reduced in diltiazem‐treated patients compared with those of the control group (p < 0.05). The data suggest that a bolus injection of diltiazem is a simple, practical and effective method to attenuate the hypertensive response to laryngoscopy and tracheal intubation.

[1]  C. Cowan Antianginal drug therapy , 1990 .

[2]  F. Khan,et al.  Effect of buprenorphine on the cardiovascular response to tracheal intubation , 1989, Anaesthesia.

[3]  A. Namiki,et al.  Attenuation of the pressor response to laryngoscopy and tracheal intubation with intravenous verapamil , 1989, Acta anaesthesiologica Scandinavica.

[4]  Y. Hatano,et al.  Intravenous administration of isosorbide dinitrate attenuates the pressor response to laryngoscopy and tracheal intubation , 1989, Acta anaesthesiologica Scandinavica.

[5]  G. Puri,et al.  Effect of nifedipine on cardiovascular responses to laryngoscopy and intubation. , 1988, British journal of anaesthesia.

[6]  A. Hunter The Prevention of Hypertension at Intubation. A Controlled Study of Intravenous Hydralazine on Patients undergoing Intracranial Surgery , 1982 .

[7]  M. Davies,et al.  The prevention of hypertension at intubation , 1981, Anaesthesia.

[8]  R. Stoelting Monitoring Surgical Patients in the Operating Room , 1979 .

[9]  R. Stoelting Attenuation of Blood Pressure Response to Laryngoscopy and Tracheal Intutation with Sodium Nitroprusside , 1979, Anesthesia and analgesia.

[10]  R. Stoelting Circulatory changes during direct laryngoscopy and tracheal intubation: influence of duration of laryngoscopy with or without prior lidocaine. , 1977, Anesthesiology.

[11]  P. Foëx,et al.  Studies of anaesthesia in relation to hypertension. II. Haemodynamic consequences of induction and endotracheal intubation. , 1972, British journal of anaesthesia.

[12]  A. Forbes,et al.  Acute hypertension during induction of anaesthesia and endotracheal intubation in normotensive man. , 1970, British journal of anaesthesia.

[13]  J. Gaddum THE PHARMACOLOGICAL BASIS OF THERAPEUTICS , 1941, Nature.