Tea for three: control of fission yeast polarity

By what molecular mechanisms do microtubules regulate the spatial distribution of actin assembly in cells? In fission yeast, a novel SH3-domain-containing protein, Tea4p, acts to bridge the microtubule plus-end-binding protein Tea1p with the actin-nucleating formin protein For3p.

[1]  Irina Kaverina,et al.  Microtubules meet substrate adhesions to arrange cell polarity. , 2003, Current opinion in cell biology.

[2]  K. Kalil,et al.  Hot +tips Guidance cues signal directly to microtubules , 2004, Neuron.

[3]  Fred Chang,et al.  Roles of the fission yeast formin for3p in cell polarity, actin cable formation and symmetric cell division , 2001, Current Biology.

[4]  P. Nurse,et al.  Growth in cell length in the fission yeast Schizosaccharomyces pombe. , 1985, Journal of cell science.

[5]  F. Verde,et al.  Regulation of a formin complex by the microtubule plus end protein tea1p , 2004, The Journal of cell biology.

[6]  P. Nurse,et al.  tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell , 1997, Cell.

[7]  F. Chang,et al.  Role of bud6p and tea1p in the interaction between actin and microtubules for the establishment of cell polarity in fission yeast , 2001, Current Biology.

[8]  B. Mayer,et al.  SH3 domains: complexity in moderation. , 2001, Journal of cell science.

[9]  F. Solomon,et al.  Microtubule Function in Morphological Differentiation: Growth Zones and Growth Cones , 1997, Cell.

[10]  K. Sawin,et al.  Role of microtubules and tea1p in establishment and maintenance of fission yeast cell polarity , 2004, Journal of Cell Science.

[11]  Sophie G. Martin,et al.  Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity. , 2005, Developmental cell.

[12]  I. Rupeš,et al.  Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast. , 1999, Molecular biology of the cell.

[13]  K. Sawin,et al.  Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips , 2003, Nature.

[14]  P. Nurse,et al.  Mis-specification of cortical identity in a fission yeast PAK mutant , 1999, Current Biology.

[15]  F. Chang.  Establishment of a cellular axis in fission yeast. , 2001, Trends in genetics : TIG.