Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia

[1]  H. Okamura,et al.  Physiological and molecular effects of interleukin-18 administration on the mouse kidney , 2018, Journal of Translational Medicine.

[2]  C. Constantinou,et al.  Pleiotropic effects of apolipoprotein C3 on HDL functionality and adipose tissue metabolic activity[S] , 2017, Journal of Lipid Research.

[3]  H. Okamura,et al.  Interleukin-18-deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis. , 2016, Translational research : the journal of laboratory and clinical medicine.

[4]  Jaak Vilo,et al.  ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap , 2015, Nucleic Acids Res..

[5]  H. Okamura,et al.  Hepatocyte Nuclear Factor 4 Alpha Is a Key Factor Related to Depression and Physiological Homeostasis in the Mouse Brain , 2015, PloS one.

[6]  S. Trauger,et al.  Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. , 2015, Cell metabolism.

[7]  M. Pellegrino,et al.  Leptin stimulates sympathetic axon outgrowth , 2014, Neuroscience Letters.

[8]  M. Macías-González,et al.  Elaidyl-sulfamide, an oleoylethanolamide-modelled PPARα agonist, reduces body weight gain and plasma cholesterol in rats , 2012, Disease Models & Mechanisms.

[9]  M. Furuhashi,et al.  Lipid Chaperones and Metabolic Inflammation , 2011, International journal of inflammation.

[10]  D. Deb,et al.  Targeted Expression of Human Vitamin D Receptor in Adipocytes Decreases Energy Expenditure and Induces Obesity in Mice* , 2011, The Journal of Biological Chemistry.

[11]  J. Orava,et al.  Different metabolic responses of human brown adipose tissue to activation by cold and insulin. , 2011, Cell metabolism.

[12]  G. Shulman,et al.  Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. , 2011, Cell metabolism.

[13]  F. Villarroya,et al.  Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue* , 2011, The Journal of Biological Chemistry.

[14]  N. Takahira,et al.  Circulating interleukin-18: A specific biomarker for atherosclerosis-prone patients with metabolic syndrome , 2011, Nutrition & metabolism.

[15]  Shengqiu Tang,et al.  Insulin-induced gene: A new regulator in lipid metabolism , 2010, Peptides.

[16]  B. Spiegelman,et al.  Transcriptional control of brown fat development. , 2010, Cell metabolism.

[17]  F. Villarroya,et al.  Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. , 2010, Cell metabolism.

[18]  W. D. van Marken Lichtenbelt,et al.  Cold-activated brown adipose tissue in healthy men. , 2009, The New England journal of medicine.

[19]  J. Orava,et al.  Functional brown adipose tissue in healthy adults. , 2009, The New England journal of medicine.

[20]  Steven P. Gygi,et al.  Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex , 2009, Nature.

[21]  X. J. Sun,et al.  Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. , 2009, American journal of physiology. Endocrinology and metabolism.

[22]  G. Shulman,et al.  Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity , 2009, Diabetes.

[23]  B. Spiegelman,et al.  PRDM16 controls a brown fat/skeletal muscle switch , 2008, Nature.

[24]  M. Furuhashi,et al.  Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets , 2008, Nature Reviews Drug Discovery.

[25]  B. Spiegelman,et al.  Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. , 2008, Genes & development.

[26]  B. Spiegelman,et al.  Transcriptional control of brown fat determination by PRDM16. , 2007, Cell metabolism.

[27]  R. Parker,et al.  Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2 , 2007, Nature.

[28]  J. Flier,et al.  Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. , 2007, Cell metabolism.

[29]  Victor M Montori,et al.  Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. , 2007, Journal of the American College of Cardiology.

[30]  S. Farmer.  Transcriptional control of adipocyte formation. , 2006, Cell metabolism.

[31]  Shizuo Akira,et al.  Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance , 2006, Nature Medicine.

[32]  F. Spener,et al.  Adipocyte-type fatty acid-binding protein as inter-compartmental shuttle for peroxisome proliferator activated receptor gamma agonists in cultured cell. , 2006, Biochimica et biophysica acta.

[33]  J. Gromada,et al.  FGF-21 as a novel metabolic regulator. , 2005, The Journal of clinical investigation.

[34]  P. Reddy.  Interleukin-18: recent advances , 2004, Current opinion in hematology.

[35]  Masafumi Koga,et al.  Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. , 2003, Metabolism: clinical and experimental.

[36]  G. Marchesini,et al.  Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome , 2003, Hepatology.

[37]  H. Okamura,et al.  Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells1 , 2001, The Journal of Immunology.

[38]  J. Harney,et al.  The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. , 2001, The Journal of clinical investigation.

[39]  M. Klingenberg.  Uncoupling Protein—A Useful Energy Dissepator , 1999, Journal of bioenergetics and biomembranes.

[40]  S. Akira,et al.  Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. , 1999, Immunity.

[41]  P. Puigserver,et al.  A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis , 1998, Cell.

[42]  S. Akira,et al.  Defective NK cell activity and Th1 response in IL-18-deficient mice. , 1998, Immunity.

[43]  C. Wernstedt,et al.  Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro * , 1998, The Journal of Biological Chemistry.

[44]  Hitoshi Yamashita,et al.  Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese , 1997, nature.

[45]  R. Kamen,et al.  Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production , 1997, Nature.

[46]  H. Okamura,et al.  Cloning of a new cytokine that induces IFN-γ production by T cells , 1995, Nature.

[47]  B. Lowell,et al.  Development of obesity in transgenic mice after genetic ablation of brown adipose tissue , 1993, Nature.

[48]  S. Yeaman,et al.  Identification and role of the basal phosphorylation site on hormone-sensitive lipase. , 1990, European journal of biochemistry.

[49]  G. Gerber,et al.  Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue: lack of a mitochondrial targeting presequence. , 1986, Nucleic acids research.

[50]  J. Weissenbach,et al.  Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein. , 1986, The Journal of biological chemistry.

[51]  T. A. Link,et al.  The uncoupling protein from brown fat mitochondria is related to the mitochondrial ADP/ATP carrier. Analysis of sequence homologies and of folding of the protein in the membrane. , 1985, The EMBO journal.

[52]  Jan Nedergaard,et al.  Brown adipose tissue: function and physiological significance. , 2004, Physiological reviews.

[53]  The Wenner-Gren Institute,et al.  Brown adipose tissue: function and physiological significance. , 2004, Physiological reviews.

[54]  H. Okamura,et al.  Interleukin-18: a novel cytokine that augments both innate and acquired immunity. , 1998, Advances in immunology.

[55]  R. Kamen,et al.  Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. , 1997, Nature.

[56]  R A Graves,et al.  Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. , 1994, Nucleic acids research.

[57]  Paul Tempst,et al.  Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa , 1994 .

[58]  E. Degerman,et al.  Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[59]  D. Nicholls,et al.  Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. , 1978, European journal of biochemistry.