Burst electromagnetic wave focusing system for medical application

Inducing apoptosis in malignant cells and controlling ES cell differentiation using subnanosecond high voltage pulses have previously been investigated, and results encouraged these authors to develop a high power burst electromagnetic wave focusing system for apoptosis induction in cancer cells. This system consists of a transmitting antenna and an ellipsoidal reflector which focuses radiation waves. The ellipsoidal reflector has the characteristic of focusing the burst electromagnetic waves radiated from the first focal point to the second focal point, thus enhancing the electric field at the second focal point. This system is immersed in heated water to avoid permittivity mismatch between living tissue and the medium in which electromagnetic waves propagate, thereby reducing the reflection and refraction at the surface of living tissue and focusing more accurately the burst electromagnetic waves on the second focal point. This paper presents the experimental and simulated results so as to compare antennas to radiate the burst electromagnetic wave to living tissue.

[1]  A. Catenaccio,et al.  Temperature dependence of the permittivity of water , 2003 .

[2]  Juergen F. Kolb,et al.  A new pulsed electric field therapy for melanoma disrupts the tumor's blood supply and causes complete remission without recurrence , 2009, International journal of cancer.

[3]  Ravindra P. Joshi,et al.  Ultrashort electrical pulses open a new gateway into biological cells , 2004 .

[4]  Sensor and Simulation Notes Note 481 31 October 2003 Analysis of Impulse-Radiating Antennas with Ellipsoidal Reflectors , 2003 .

[5]  K. Schoenbach,et al.  Intracellular effect of ultrashort electrical pulses , 2001, Bioelectromagnetics.

[6]  Juergen F Kolb,et al.  Leukemic cell intracellular responses to nanosecond electric fields. , 2004, Biochemical and biophysical research communications.

[7]  K. Schoenbach,et al.  Bioelectrics-new applications for pulsed power technology , 2001, PPPS-2001 Pulsed Power Plasma Science 2001. 28th IEEE International Conference on Plasma Science and 13th IEEE International Pulsed Power Conference. Digest of Papers (Cat. No.01CH37251).