Inflammatory processes in cardiovascular disease: a route to targeted therapies

[1]  S. Schwartz Faculty Opinions recommendation of Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. , 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[2]  Paulino Vacas-Jacques,et al.  Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging. , 2016, JACC. Cardiovascular imaging.

[3]  Matthew D. Robson,et al.  Arterial Effects of Canakinumab in Patients With Atherosclerosis and Type 2 Diabetes or Glucose Intolerance , 2016, Journal of the American College of Cardiology.

[4]  B. Amundsen,et al.  Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial. , 2016, European heart journal.

[5]  U. Wisløff,et al.  Circulating microRNAs predict future fatal myocardial infarction in healthy individuals - The HUNT study. , 2016, Journal of molecular and cellular cardiology.

[6]  K. Reich,et al.  Secukinumab long-term safety experience: A pooled analysis of 10 phase II and III clinical studies in patients with moderate to severe plaque psoriasis. , 2016, Journal of the American Academy of Dermatology.

[7]  S. Nourshargh,et al.  Reverse Migration of Neutrophils: Where, When, How, and Why? , 2016, Trends in immunology.

[8]  A. Parkhomenko,et al.  Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial. , 2016, JAMA.

[9]  Stephan G. Nekolla,et al.  Prospective Evaluation of 18F-Fluorodeoxyglucose Uptake in Postischemic Myocardium by Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging as a Prognostic Marker of Functional Outcome , 2016, Circulation. Cardiovascular imaging.

[10]  C. Weber,et al.  Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype , 2016, European heart journal.

[11]  M. Carrier,et al.  Effects of P-Selectin Antagonist Inclacumab in Patients Undergoing Coronary Artery Bypass Graft Surgery: SELECT-CABG Trial. , 2016, Journal of the American College of Cardiology.

[12]  D. Su,et al.  The roles of macrophage autophagy in atherosclerosis , 2016, Acta Pharmacologica Sinica.

[13]  P. Libby,et al.  Targeting Interleukin-1&bgr; Reduces Leukocyte Production After Acute Myocardial Infarction , 2015, Circulation.

[14]  Kyung-Han Lee,et al.  Carotid FDG Uptake Improves Prediction of Future Cardiovascular Events in Asymptomatic Individuals. , 2015, JACC. Cardiovascular imaging.

[15]  Laura S. Shankman,et al.  Correction: Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis , 2015, Nature Medicine.

[16]  Laura S. Shankman,et al.  KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis , 2015, Nature Medicine.

[17]  B. Prendergast,et al.  Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans , 2015, European heart journal.

[18]  T. Weinberger,et al.  Myocardial infarction: a critical role of macrophages in cardiac remodeling , 2015, Front. Physiol..

[19]  C. Newgard,et al.  Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease. , 2015, Circulation. Cardiovascular genetics.

[20]  K. Moore,et al.  Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like Phenotype , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[21]  O. Farokhzad,et al.  Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice , 2015, Science Translational Medicine.

[22]  G. Biondi-Zoccai,et al.  Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies). , 2015, The American journal of cardiology.

[23]  R. Feil,et al.  Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis , 2014, Circulation research.

[24]  F. Bengel,et al.  Characterizing the Inflammatory Tissue Response to Acute Myocardial Infarction by Clinical Multimodality Noninvasive Imaging , 2014, Circulation. Cardiovascular imaging.

[25]  Hyeong Soo Nam,et al.  Fully Integrated High-Speed Intravascular Optical Coherence Tomography/Near-Infrared Fluorescence Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence–Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels , 2014, Circulation. Cardiovascular interventions.

[26]  J. Rudd,et al.  PET imaging of inflammation in atherosclerosis , 2014, Nature Reviews Cardiology.

[27]  Ralph Weissleder,et al.  Chronic variable stress activates hematopoietic stem cells , 2014, Nature Medicine.

[28]  T. Spector,et al.  Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study , 2014, Circulation.

[29]  P. Pais,et al.  Darapladib for preventing ischemic events in stable coronary heart disease. , 2014, The New England journal of medicine.

[30]  S. Allahverdian,et al.  Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis , 2014, Circulation.

[31]  M. Dweck,et al.  18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial , 2014, The Lancet.

[32]  Sungeun Kim,et al.  Metabolic Activity of the Spleen and Bone Marrow in Patients With Acute Myocardial Infarction Evaluated by 18F-Fluorodeoxyglucose Positron Emission Tomograpic Imaging , 2014, Circulation. Cardiovascular imaging.

[33]  J. Kastelein,et al.  Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial. , 2014, JAMA.

[34]  P. Colonna,et al.  Early short-term doxycycline therapy in patients with acute myocardial infarction and left ventricular dysfunction to prevent the ominous progression to adverse remodelling: the TIPTOP trial. , 2014, European heart journal.

[35]  Hisashi Adachi,et al.  Inflammation, atherosclerosis, and coronary artery disease. , 2005, The New England journal of medicine.

[36]  A. Hall,et al.  The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study , 2013, European heart journal.

[37]  Bo Yu,et al.  In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. , 2013, Journal of the American College of Cardiology.

[38]  N. Frangogiannis,et al.  IL-1 Induces Proinflammatory Leukocyte Infiltration and Regulates Fibroblast Phenotype in the Infarcted Myocardium , 2013, The Journal of Immunology.

[39]  Maarten Hulsmans,et al.  MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. , 2013, Cardiovascular research.

[40]  K. Dickstein,et al.  Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction. , 2013, International journal of cardiology.

[41]  K. Moore,et al.  Macrophages in atherosclerosis: a dynamic balance , 2013, Nature Reviews Immunology.

[42]  K. Fukuda,et al.  Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction. , 2013, Journal of molecular and cellular cardiology.

[43]  P. Libby,et al.  Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis. , 2013, American heart journal.

[44]  P. Libby,et al.  Local proliferation dominates lesional macrophage accumulation in atherosclerosis , 2013, Nature Medicine.

[45]  M. Olson,et al.  Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs , 2013, Cell Death and Differentiation.

[46]  J. Tardif,et al.  Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: results of the SELECT-ACS trial. , 2013, Journal of the American College of Cardiology.

[47]  D. Newby,et al.  Cardiovascular effects of tumour necrosis factor α antagonism in patients with acute myocardial infarction: a first in human study , 2013, Heart.

[48]  Z. Malik,et al.  Cardiac myocyte exosomes: stability, HSP60, and proteomics. , 2013, American journal of physiology. Heart and circulatory physiology.

[49]  B. Strober,et al.  Long‐term safety of ustekinumab in patients with moderate‐to‐severe psoriasis: final results from 5 years of follow‐up , 2013, The British journal of dermatology.

[50]  Seok Hyun Yun,et al.  Endoscopic Time-Lapse Imaging of Immune Cells in Infarcted Mouse Hearts , 2013, Circulation research.

[51]  Qing Xu,et al.  Fluid-Phase Pinocytosis of Native Low Density Lipoprotein Promotes Murine M-CSF Differentiated Macrophage Foam Cell Formation , 2013, PloS one.

[52]  Ralph Weissleder,et al.  Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques , 2013, Circulation research.

[53]  N. Voelkel,et al.  Interleukin‐1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse , 2013, Experimental physiology.

[54]  Ali Yilmaz,et al.  Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach. , 2013, European heart journal.

[55]  K. Moon,et al.  Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice. , 2013, Atherosclerosis.

[56]  E. Olson,et al.  MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment. , 2013, The Journal of clinical investigation.

[57]  D. Birchall,et al.  Increased expression of fatty acid binding protein 4 and leptin in resident macrophages characterises atherosclerotic plaque rupture , 2013, Atherosclerosis.

[58]  J. H. Rudd,et al.  Anti-Tumor Necrosis Factor-&agr; Therapy Reduces Aortic Inflammation and Stiffness in Patients With Rheumatoid Arthritis , 2012, Circulation.

[59]  O. Wagner,et al.  Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype , 2012, EMBO molecular medicine.

[60]  Tom MacGillivray,et al.  Ultrasmall Superparamagnetic Particles of Iron Oxide in Patients With Acute Myocardial Infarction: Early Clinical Experience , 2012, Circulation. Cardiovascular imaging.

[61]  J. H. Rudd,et al.  Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis. , 2012, JACC. Cardiovascular imaging.

[62]  K. Channon,et al.  A Leukocyte-Mimetic Magnetic Resonance Imaging Contrast Agent Homes Rapidly to Activated Endothelium and Tracks With Atherosclerotic Lesion Macrophage Content , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[63]  Charles P. Lin,et al.  Myocardial infarction accelerates atherosclerosis , 2012, Nature.

[64]  E. Topol,et al.  Pharmacogenetics: Point-of-care genetic testing—a new frontier explored , 2012, Nature Reviews Cardiology.

[65]  G. Ertl,et al.  Activation of CD4+ T Lymphocytes Improves Wound Healing and Survival After Experimental Myocardial Infarction in Mice , 2012, Circulation.

[66]  B. Caramelli,et al.  Treatment With Methotrexate Inhibits Atherogenesis in Cholesterol-Fed Rabbits , 2012, Journal of cardiovascular pharmacology.

[67]  M. Olson,et al.  How apoptotic cells aid in the removal of their own cold dead bodies , 2012, Cell Death and Differentiation.

[68]  N. Frangogiannis,et al.  Regulation of the inflammatory response in cardiac repair. , 2012, Circulation research.

[69]  K. Werdan,et al.  Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock , 2012, Clinical Research in Cardiology.

[70]  Ahmed Tawakol,et al.  PET/MRI of inflammation in myocardial infarction. , 2012, Journal of the American College of Cardiology.

[71]  Y. Devaux,et al.  Proteomic analysis of plasma samples from patients with acute myocardial infarction identifies haptoglobin as a potential prognostic biomarker. , 2011, Journal of proteomics.

[72]  S. Stepaniants,et al.  A Gene Expression Signature That Classifies Human Atherosclerotic Plaque by Relative Inflammation Status , 2011, Circulation. Cardiovascular genetics.

[73]  N. Voelkel,et al.  The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse , 2011, Proceedings of the National Academy of Sciences.

[74]  M. Gassmann,et al.  Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism , 2011, Circulation research.

[75]  P. Libby,et al.  Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). , 2011, American heart journal.

[76]  K. Clément,et al.  CD14dimCD16+ and CD14+CD16+ Monocytes in Obesity and During Weight Loss: Relationships With Fat Mass and Subclinical Atherosclerosis , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[77]  Daniel G. Anderson,et al.  Therapeutic siRNA silencing in inflammatory monocytes , 2011, Nature Biotechnology.

[78]  A. Szallasi,et al.  Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials. , 2011, Current topics in medicinal chemistry.

[79]  P. Libby,et al.  Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomography. , 2011, Journal of the American College of Cardiology.

[80]  N. Voelkel,et al.  Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury. , 2011, Journal of molecular and cellular cardiology.

[81]  Xenophon Papademetris,et al.  Targeted Imaging of the Spatial and Temporal Variation of Matrix Metalloproteinase Activity in a Porcine Model of Postinfarct Remodeling: Relationship to Myocardial Dysfunction , 2011, Circulation. Cardiovascular imaging.

[82]  Klaus Ley,et al.  Monocyte and macrophage dynamics during atherogenesis. , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[83]  V. Ntziachristos,et al.  Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques , 2011, Science Translational Medicine.

[84]  Sean C. Bendall,et al.  Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum , 2011, Science.

[85]  A. Tedgui,et al.  Recent Advances on the Role of Cytokines in Atherosclerosis , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[86]  Jean-Baptiste Michel,et al.  Intraplaque haemorrhages as the trigger of plaque vulnerability , 2011, European heart journal.

[87]  S. Young,et al.  Reversal of Hyperlipidemia With a Genetic Switch Favorably Affects the Content and Inflammatory State of Macrophages in Atherosclerotic Plaques , 2011, Circulation.

[88]  Chantal M Boulanger,et al.  Microparticles From Human Atherosclerotic Plaques Promote Endothelial ICAM-1–Dependent Monocyte Adhesion and Transendothelial Migration , 2011, Circulation research.

[89]  W. Schrödl,et al.  Specific Removal of C-Reactive Protein by Apheresis in a Porcine Cardiac Infarction Model , 2010, Blood Purification.

[90]  R. Weissleder,et al.  Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction , 2010, Circulation research.

[91]  Y. Adler,et al.  COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial. , 2010, European heart journal.

[92]  Jurgen E. Schneider,et al.  In Vivo Quantification of Vcam-1 Expression in Renal Ischemia Reperfusion Injury Using Non-Invasive Magnetic Resonance Molecular Imaging , 2010, PloS one.

[93]  H. Matsubara,et al.  Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice. , 2010, Cardiovascular research.

[94]  Jing Li,et al.  Secreted monocytic miR-150 enhances targeted endothelial cell migration. , 2010, Molecular cell.

[95]  M. Pittet,et al.  Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. , 2010, Circulation.

[96]  Crislyn D'Souza-Schorey,et al.  Microvesicles: mediators of extracellular communication during cancer progression , 2010, Journal of Cell Science.

[97]  Wouter Peeters,et al.  Composition of Carotid Atherosclerotic Plaque Is Associated With Cardiovascular Outcome: A Prognostic Study , 2010, Circulation.

[98]  P. Libby,et al.  Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. , 2010, Journal of the American College of Cardiology.

[99]  Gerd Schmitz,et al.  HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. , 2010, The international journal of biochemistry & cell biology.

[100]  Zahi A Fayad,et al.  High-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis. , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[101]  Olivier Levillain,et al.  Macrophage Plasticity in Experimental Atherosclerosis , 2010, PloS one.

[102]  D. Böckler,et al.  Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice1 , 2009, The Journal of Immunology.

[103]  R. Weissleder,et al.  Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis. , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[104]  Ralph Weissleder,et al.  Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[105]  A. Poliakov,et al.  Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance , 2009, Diabetes.

[106]  O. Wagner,et al.  Local complement activation triggers neutrophil recruitment to the site of thrombus formation in acute myocardial infarction , 2009, Thrombosis and Haemostasis.

[107]  P. Libby,et al.  Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites , 2009, Science.

[108]  T. Akasaka,et al.  Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. , 2009, Journal of the American College of Cardiology.

[109]  J. Liao,et al.  Genetically elevated C-reactive protein and ischemic vascular disease , 2009, Current atherosclerosis reports.

[110]  M. Daemen,et al.  Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis , 2009, The Journal of pathology.

[111]  Heather L Rick,et al.  Varespladib (A-002), a Secretory Phospholipase A2 Inhibitor, Reduces Atherosclerosis and Aneurysm Formation in ApoE−/− Mice , 2009, Journal of cardiovascular pharmacology.

[112]  A. Maseri,et al.  Expansion of T-Cell Receptor &zgr;dim Effector T Cells in Acute Coronary Syndromes , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[113]  P. Libby,et al.  Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. , 2008, The New England journal of medicine.

[114]  Ping Zhang,et al.  Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development , 2008, Nature Medicine.

[115]  B. Funke,et al.  High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart , 2008, Circulation.

[116]  G. Biondi-Zoccai,et al.  Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction , 2008, Circulation.

[117]  E. Minder,et al.  Proinflammatory cytokines in acute myocardial infarction with and without cardiogenic shock , 2008, Clinical Research in Cardiology.

[118]  T. Simon,et al.  Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice , 2008, Circulation.

[119]  J. Sluijter,et al.  Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness. , 2008, Atherosclerosis.

[120]  E. Fisher,et al.  Rapid regression of atherosclerosis: insights from the clinical and experimental literature , 2008, Nature Clinical Practice Cardiovascular Medicine.

[121]  P. V. van Diest,et al.  HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages. , 2007, Atherosclerosis.

[122]  P. Libby,et al.  The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions , 2007, The Journal of experimental medicine.

[123]  M. Fishbein,et al.  Role of the JAK/STAT Pathway in the Regulation of Interleukin-8 Transcription by Oxidized Phospholipids in Vitro and in Atherosclerosis in Vivo* , 2007, Journal of Biological Chemistry.

[124]  M. Gaestel,et al.  Systemic Deficiency of the MAP Kinase-Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice , 2007, Circulation research.

[125]  J. Borén,et al.  Ira Tabas , Kevin Jon Williams and Jan Borén and Therapeutic Implications Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis : Update , 2007 .

[126]  A. Rebuzzi,et al.  Unusual CD4+CD28nullT Lymphocytes and Recurrence of Acute Coronary Events , 2007 .

[127]  Jurgen E Schneider,et al.  In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide , 2007, Nature Medicine.

[128]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[129]  C. Weber,et al.  Platelets as Immune Cells: Bridging Inflammation and Cardiovascular Disease , 2007, Circulation research.

[130]  Ajai Kumar Jain,et al.  PexeLizumab for Acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: A randomized controlled trial , 2007 .

[131]  F. Tacke,et al.  Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. , 2007, The Journal of clinical investigation.

[132]  G. Keren,et al.  Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes. , 2006, European heart journal.

[133]  S. Ignjatović,et al.  Serial measurements of C-reactive protein after acute myocardial infarction in predicting one-year outcome. , 2006, International heart journal.

[134]  Mario J. Garcia,et al.  Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial. , 2006, Journal of the American College of Cardiology.

[135]  M. Ramanathan,et al.  Dynamics of interferon-β modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-β neutralizing antibodies , 2006, Journal of Neuroimmunology.

[136]  M. Satoh,et al.  Activated toll-like receptor 4 in monocytes is associated with heart failure after acute myocardial infarction. , 2006, International journal of cardiology.

[137]  Peter Libby,et al.  Inflammation and cardiovascular disease mechanisms. , 2006, The American journal of clinical nutrition.

[138]  T. Klingler,et al.  Noninvasive Discrimination of Rejection in Cardiac Allograft Recipients Using Gene Expression Profiling , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[139]  P. Jorens,et al.  Systemic Inflammation and Reperfusion Injury in Patients With Acute Myocardial Infarction , 2005, Mediators of inflammation.

[140]  G. Prestwich,et al.  Regulation of lung injury and repair by Toll-like receptors and hyaluronan , 2005, Nature Medicine.

[141]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[142]  L. Sleeper,et al.  Systemic inflammatory response syndrome after acute myocardial infarction complicated by cardiogenic shock. , 2005, Archives of internal medicine.

[143]  J. Omens,et al.  Etanercept or intravenous immunoglobulin attenuates expression of genes involved in post-myocardial infarction remodeling. , 2005, Cardiovascular research.

[144]  A. Sanabria,et al.  Randomized controlled trial. , 2005, World journal of surgery.

[145]  C. Sabin,et al.  Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[146]  D. Greaves,et al.  Mechanisms of Disease: macrophage-derived foam cells emerging as therapeutic targets in atherosclerosis , 2005, Nature Clinical Practice Cardiovascular Medicine.

[147]  Paul Schoenhagen,et al.  Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. , 2005, The New England journal of medicine.

[148]  Y. Okada,et al.  Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice. , 2005, The Journal of clinical investigation.

[149]  D. Mele,et al.  Tumor Necrosis Factor- (cid:1) Receptor 1 Is a Major Predictor of Mortality and New-Onset Heart Failure in Patients With Acute Myocardial Infarction The Cytokine-Activation and Long-Term Prognosis in Myocardial Infarction (C-ALPHA) Study , 2005 .

[150]  JanNilsson,et al.  Inhibition of Tumor Necrosis Factor-α Reduces Atherosclerosis in Apolipoprotein E Knockout Mice , 2004 .

[151]  D. Greaves,et al.  Broad-Spectrum CC-Chemokine Blockade by Gene Transfer Inhibits Macrophage Recruitment and Atherosclerotic Plaque Formation in Apolipoprotein E–Knockout Mice , 2004, Circulation.

[152]  R. Bolli,et al.  IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2. , 2004, Cardiovascular research.

[153]  L. Hovgaard,et al.  Inhibition of Tumor Necrosis Factor-&agr; Reduces Atherosclerosis in Apolipoprotein E Knockout Mice , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[154]  S. Blankenberg,et al.  CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-α levels , 2004, Thrombosis and Haemostasis.

[155]  K. Tsuchida,et al.  In vivo transfer of soluble TNF‐alpha receptor 1 gene improves cardiac function and reduces infarct size after myocardial infarction in rats , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[156]  B. Thinkhamrop,et al.  A multicentre, randomized, double‐blind, placebo‐controlled trial of primary cryptococcal meningitis prophylaxis in HIV‐infected patients with severe immune deficiency , 2004, HIV medicine.

[157]  Vilmundur Gudnason,et al.  C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. , 2004, The New England journal of medicine.

[158]  R. Andriantsitohaina,et al.  Shed Membrane Particles From T Lymphocytes Impair Endothelial Function and Regulate Endothelial Protein Expression , 2004, Circulation.

[159]  Qingbo Xu,et al.  Heat-Shock Protein 60-Reactive CD4+CD28null T Cells in Patients With Acute Coronary Syndromes , 2004, Circulation.

[160]  S. Reis,et al.  801-1 In women with symptoms of ischemic heart disease, global and regional myocardial perfusion status by magnetic resonance imaging better assigns risk: Results from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) , 2004 .

[161]  U. Goldbourt,et al.  Predictive value of elevated white blood cell count in patients with preexisting coronary heart disease: the Bezafibrate Infarction Prevention Study. , 2004, Archives of internal medicine.

[162]  S. Reis,et al.  Serum Amyloid A as a Predictor of Coronary Artery Disease and Cardiovascular Outcome in Women: The National Heart, Lung, and Blood Institute–Sponsored Women’s Ischemia Syndrome Evaluation (WISE) , 2004, Circulation.

[163]  J. Vinten-johansen Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. , 2004, Cardiovascular research.

[164]  E. Fisher,et al.  Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[165]  P. Tipping,et al.  The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. , 2003, The American journal of pathology.

[166]  J. Oyama,et al.  Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice , 2003, Circulation.

[167]  P. Ridker Clinical application of C-reactive protein for cardiovascular disease detection and prevention. , 2003, Circulation.

[168]  Gary L Myers,et al.  Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. , 2003, Circulation.

[169]  A. Beg,et al.  Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. , 2002, Trends in immunology.

[170]  R. Gibbons,et al.  The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study. , 2002, Journal of the American College of Cardiology.

[171]  Osamu Takeuchi,et al.  Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial Infarction , 2002, Circulation.

[172]  E. Topol,et al.  Recombinant Soluble P-Selectin Glycoprotein Ligand-Ig (rPSGL-Ig) Attenuates Infarct Size and Myeloperoxidase Activity in a Canine Model of Ischemia-Reperfusion , 2002, Thrombosis and Haemostasis.

[173]  C. Devlin,et al.  Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[174]  Vincenza Dolo,et al.  Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells. , 2002, The American journal of pathology.

[175]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[176]  R. Gibbons,et al.  Double-Blind, Randomized Trial of an Anti-CD18 Antibody in Conjunction With Recombinant Tissue Plasminogen Activator for Acute Myocardial Infarction: Limitation of Myocardial Infarction Following Thrombolysis in Acute Myocardial Infarction (LIMIT AMI) Study , 2001, Circulation.

[177]  A. Tedgui,et al.  Circulating Microparticles From Patients With Myocardial Infarction Cause Endothelial Dysfunction , 2001, Circulation.

[178]  Tadashi Miyamoto,et al.  Neutralization of interleukin-1β in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling , 2001 .

[179]  A. Folsom,et al.  White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women: atherosclerosis risk in communities study. , 2001, American journal of epidemiology.

[180]  M. Entman,et al.  Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia. , 2001, The American journal of pathology.

[181]  K. F. Chan,et al.  Signaling by the TNF receptor superfamily and T cell homeostasis. , 2000, Immunity.

[182]  P. Libby,et al.  Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. , 2000, The Journal of clinical investigation.

[183]  R. Frye,et al.  Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. , 2000, Circulation.

[184]  B. Horne,et al.  Soluble VCAM-1 and E-Selectin, but Not ICAM-1 Discriminate Endothelial Injury in Patients with Documented Coronary Artery Disease , 2000, Cardiology.

[185]  G Baumgarten,et al.  Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[186]  J. Mesirov,et al.  Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. , 1999, Science.

[187]  R. Medzhitov,et al.  Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. , 1999, The Journal of clinical investigation.

[188]  K. Williams,et al.  Atherosclerosis--an inflammatory disease. , 1999, The New England journal of medicine.

[189]  A. Rebuzzi,et al.  Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. , 1999, Circulation.

[190]  M. Mesri,et al.  Endothelial cell activation by leukocyte microparticles. , 1998, Journal of immunology.

[191]  A. Whitty,et al.  Inhibitory Specificity of the Anti-inflammatory Myxoma Virus Serpin, SERP-1* , 1998, The Journal of Biological Chemistry.

[192]  R. Hynes,et al.  The combined role of P- and E-selectins in atherosclerosis. , 1998, The Journal of clinical investigation.

[193]  Z. Galis,et al.  Extracellular matrix modulates macrophage functions characteristic to atheroma: collagen type I enhances acquisition of resident macrophage traits by human peripheral blood monocytes in vitro. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[194]  P. Ridker,et al.  Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. , 1998, Circulation.

[195]  J. Arnal,et al.  Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty-streak formation in apolipoprotein E-deficient mice. , 1998, Circulation.

[196]  E. Boerwinkle,et al.  Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. , 1997, Circulation.

[197]  L. Brunton,et al.  Small heat shock proteins and protection against ischemic injury in cardiac myocytes. , 1997, Circulation.

[198]  G. Lip,et al.  Soluble P-selectin in Atherosclerosis: A Comparison with Endothelial Cell and Platelet Markers , 1997, Thrombosis and Haemostasis.

[199]  P. Ridker,et al.  Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. , 1997, The New England journal of medicine.

[200]  C. Mackay,et al.  Complement C5a, TGF-beta 1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion. , 1997, Circulation.

[201]  K. Williams,et al.  Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. , 1996, The Journal of clinical investigation.

[202]  P. Lachmann,et al.  Complement-induced release of monocyte chemotactic protein-1 from human smooth muscle cells. A possible initiating event in atherosclerotic lesion formation. , 1996, Arteriosclerosis, thrombosis, and vascular biology.

[203]  M. Arai,et al.  An anti-CD18 antibody limits infarct size and preserves left ventricular function in dogs with ischemia and 48-hour reperfusion. , 1996, Journal of the American College of Cardiology.

[204]  H. Weisman,et al.  A chimeric IgG4 monoclonal antibody directed against CD18 reduces infarct size in a primate model of myocardial ischemia and reperfusion. , 1995, Journal of the American College of Cardiology.

[205]  J. Hakim,et al.  Reactive oxygen species rapidly increase endothelial ICAM-1 ability to bind neutrophils without detectable upregulation. , 1994, Blood.

[206]  T. Sakamoto,et al.  Elevated plasma interleukin-6 levels in patients with acute myocardial infarction. , 1993, American heart journal.

[207]  W. Dreyer,et al.  Kinetics of C5a release in cardiac lymph of dogs experiencing coronary artery ischemia-reperfusion injury. , 1992, Circulation research.

[208]  K. Tomooka,et al.  Activation of complement in normal serum by hydrogen peroxide and hydrogen peroxide‐related oxygen radicals produced by activated neutrophils , 1992, Clinical and experimental immunology.

[209]  J. Griffin,et al.  Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. , 1991, Blood.

[210]  M. Cybulsky,et al.  Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. , 1991, Science.

[211]  G. R. Carson,et al.  Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. , 1990, Science.

[212]  W. Weintraub,et al.  Elevation of C-reactive protein in "active" coronary artery disease. , 1990, The American journal of cardiology.

[213]  B. Passlick,et al.  Identification and characterization of a novel monocyte subpopulation in human peripheral blood. , 1989, Blood.

[214]  山本 高司,et al.  Dynamic balance とその訓練効果 , 1978 .

[215]  R. van Furth,et al.  THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES , 1968, The Journal of experimental medicine.

[216]  M. Peberdy,et al.  Effects of Prolastin C (Plasma-Derived Alpha-1 Antitrypsin) on the acute inflammatory response in patients with ST-segment elevation myocardial infarction (from the VCU-alpha 1-RT pilot study). , 2015, The American journal of cardiology.

[217]  Masafumi Takahashi NLRP3 inflammasome as a novel player in myocardial infarction. , 2014, International heart journal.

[218]  E. Falk,et al.  Mechanisms of Plaque Formation and Rupture , 2014 .

[219]  J. Stevens,et al.  The Atherosclerosis Risk in Communities Study , 2013 .

[220]  J. S. Janicki,et al.  Cardiac mast cells: the centrepiece in adverse myocardial remodelling. , 2011, Cardiovascular research.

[221]  M. Cheitlin COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial , 2011 .

[222]  Eric Boerwinkle,et al.  The Atherosclerosis Risk in Communities (ARIC) Study , 2011 .

[223]  A. Rebuzzi,et al.  Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary events. , 2007, Journal of the American College of Cardiology.

[224]  J. Debatin,et al.  Ultrasmall superparamagnetic iron oxide-enhanced MR imaging of atherosclerotic plaque in hyperlipidemic rabbits. , 2002, Academic radiology.

[225]  前川 尚也 Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-α , 2002 .

[226]  E. Glaser The randomized clinical trial. , 1972, The New England journal of medicine.