Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen

[1]  Shu-qin Guo,et al.  Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway , 2019, Bioscience reports.

[2]  Leisheng Jiang,et al.  TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway , 2019, Journal of Orthopaedic Surgery and Research.

[3]  Aofei Yang,et al.  β‑ecdysterone protects against apoptosis by promoting autophagy in nucleus pulposus cells and ameliorates disc degeneration. , 2019, Molecular medicine reports.

[4]  Peng Li,et al.  Potential therapeutic role of Co‐Q10 in alleviating intervertebral disc degeneration and suppressing IL‐1&bgr;‐mediated inflammatory reaction in NP cells , 2018, International Immunopharmacology.

[5]  Shaoyu Zhu,et al.  17β-Estradiol/extrogen receptor β alleviates apoptosis and enhances matrix biosynthesis of nucleus pulposus cells through regulating oxidative damage under a high glucose condition. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[6]  M. Millecamps,et al.  Dysregulation of the Inflammatory Mediators in the Multifidus Muscle After Spontaneous Intervertebral Disc Degeneration SPARC-null Mice is Ameliorated by Physical Activity , 2018, Spine.

[7]  Z. Fang,et al.  Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration in vivo , 2018, Front. Pharmacol..

[8]  Xigao Cheng,et al.  17β-estradiol protects nucleus pulposus cells from serum deprivation-induced apoptosis and regulates expression of MMP-3 and MMP-13 through promotion of autophagy. , 2018, Biochemical and biophysical research communications.

[9]  M. Millecamps,et al.  Delayed onset of persistent discogenic axial and radiating pain after a single-level lumbar intervertebral disc injury in mice , 2018, Pain.

[10]  W. Ding,et al.  17β-Estradiol inhibits intervertebral disc degeneration by down-regulating MMP-3 and MMP-13 and up-regulating type II collagen in a rat model , 2018, Artificial cells, nanomedicine, and biotechnology.

[11]  Anirudh Sharma The Role of Adipokines in Intervertebral Disc Degeneration , 2018, Medical sciences.

[12]  B. Liu,et al.  Protective effect of estrogen against intervertebral disc degeneration is attenuated by miR-221 through targeting estrogen receptor &agr; , 2018, Acta biochimica et biophysica Sinica.

[13]  J. Block,et al.  Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates. , 2018, American journal of translational research.

[14]  L. Pimenta,et al.  Elastomeric Lumbar Total Disc Replacement: Clinical and Radiological Results With Minimum 84 Months Follow-Up , 2018, International Journal of Spine Surgery.

[15]  Safdar N. Khan,et al.  Mast Cell-Intervertebral disc cell interactions regulate inflammation, catabolism and angiogenesis in Discogenic Back Pain , 2017, Scientific Reports.

[16]  V. Miller,et al.  An update on hormone therapy in postmenopausal women: mini-review for the basic scientist. , 2017, American journal of physiology. Heart and circulatory physiology.

[17]  W. Ding,et al.  Protective role of 17β-estradiol on tumor necrosis factor-α-induced apoptosis in human nucleus pulposus cells , 2017, Molecular medicine reports.

[18]  Bu-wei Yu,et al.  Estrogen receptors involvement in intervertebral discogenic pain of the elderly women: colocalization and correlation with the expression of Substance P in nucleus pulposus , 2017, Oncotarget.

[19]  Pei Li,et al.  17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway , 2017, International journal of biological sciences.

[20]  Shu-Jun Zhang,et al.  Tumor necrosis factor-&agr;: a key contributor to intervertebral disc degeneration , 2017, Acta biochimica et biophysica Sinica.

[21]  W. Ding,et al.  17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway , 2016, Medical science monitor : international medical journal of experimental and clinical research.

[22]  Jùn-Qīng Wáng,et al.  Increased low back pain prevalence in females than in males after menopause age: evidences based on synthetic literature review. , 2016, Quantitative imaging in medicine and surgery.

[23]  Hui-lin Yang,et al.  17β-Estradiol Protects Rat Annulus Fibrosus Cells Against Apoptosis via α1 Integrin-Mediated Adhesion to Type I Collagen: An In-vitro Study , 2016, Medical science monitor : international medical journal of experimental and clinical research.

[24]  B. Chong,et al.  Expression and functional roles of estrogen receptor GPR30 in human intervertebral disc , 2016, The Journal of Steroid Biochemistry and Molecular Biology.

[25]  N. Hanley,et al.  Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord‐specific markers during early human intervertebral disc development , 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[26]  W. Ding,et al.  Combined effect of 17β-estradiol and resveratrol against apoptosis induced by interleukin-1β in rat nucleus pulposus cells via PI3K/Akt/caspase-3 pathway , 2016, PeerJ.

[27]  Da-long,et al.  Protective effect of 17 β-estradiol on hydrogen peroxide induced apoptosis of rat nucleus pulposus cells , 2016 .

[28]  R. Santen,et al.  Celebrating 75 years of oestradiol. , 2015, Journal of molecular endocrinology.

[29]  R. Khalil,et al.  Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease , 2015, The Journal of Pharmacology and Experimental Therapeutics.

[30]  Jian Zhang,et al.  Interleukin-1β in intervertebral disk degeneration. , 2015, Clinica chimica acta; international journal of clinical chemistry.

[31]  B. Meij,et al.  The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs. , 2015, European cells & materials.

[32]  James D. Kang,et al.  Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions? , 2015, Clinical orthopaedics and related research.

[33]  S. Yusuf,et al.  The burden of disease in older people and implications for health policy and practice , 2015, The Lancet.

[34]  W. Ding,et al.  17β-Estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13 , 2015, Apoptosis.

[35]  Yonglin Yu,et al.  [RESEARCH STATUS ON MOLECULAR BASIS OF INTERVERTEBRAL DISC DEGENERATION AND REPAIRING EFFECT OF PLATELET-RICH PLASMA]. , 2015, Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.

[36]  W. Ding,et al.  Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells. , 2014, Molecular medicine reports.

[37]  S. Cha,et al.  Effects of different hormone therapies on breast pain in recently postmenopausal women: findings from the Mayo Clinic KEEPS breast pain ancillary study. , 2014, Journal of women's health.

[38]  J. Lu,et al.  Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies , 2014, Cell proliferation.

[39]  Yue Huang,et al.  Upregulation of Tumor Necrosis Factor &agr; and ADAMTS-5, But Not ADAMTS-4, in Human Intervertebral Cartilage Endplate With Modic Changes , 2014, Spine.

[40]  Zu-de Liu,et al.  Estrogen receptor expression in lumbar intervertebral disc of the elderly: gender- and degeneration degree-related variations. , 2014, Joint, bone, spine : revue du rhumatisme.

[41]  S. Ferguson,et al.  Physiological testosterone levels enhance chondrogenic extracellular matrix synthesis by male intervertebral disc cells in vitro, but not by mesenchymal stem cells. , 2014, The spine journal : official journal of the North American Spine Society.

[42]  Feng Zhang,et al.  17β-Estradiol protects against apoptosis induced by levofloxacin in rat nucleus pulposus cells by upregulating integrin α2β1 , 2014, Apoptosis.

[43]  Fan Ding,et al.  Cell death in intervertebral disc degeneration , 2013, Apoptosis.

[44]  C. Kepler,et al.  The molecular basis of intervertebral disc degeneration. , 2013, The spine journal : official journal of the North American Spine Society.

[45]  Gail M. Williams,et al.  A systematic review of the global prevalence of low back pain. , 2012, Arthritis and rheumatism.

[46]  A. Ahuja,et al.  Effect of ovariectomy on contrast agent diffusion into lumbar intervertebral disc: a dynamic contrast-enhanced MRI study in female rats. , 2012, Magnetic resonance imaging.

[47]  M. Takigawa,et al.  A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes. , 2012, Biochemical and biophysical research communications.

[48]  R. Hoover,et al.  Estrogen metabolism and risk of breast cancer in postmenopausal women. , 2012, Journal of the National Cancer Institute.

[49]  James Melrose,et al.  Mechanical Destabilization Induced by Controlled Annular Incision of the Intervertebral Disc Dysregulates Metalloproteinase Expression and Induces Disc Degeneration , 2012, Spine.

[50]  J. Manson,et al.  Breast tenderness and breast cancer risk in the estrogen plus progestin and estrogen-alone women’s health initiative clinical trials , 2012, Breast Cancer Research and Treatment.

[51]  C. Kepler,et al.  Intervertebral Disk Degeneration and Emerging Biologic Treatments , 2011, The Journal of the American Academy of Orthopaedic Surgeons.

[52]  J. Griffith,et al.  Menopause causes vertebral endplate degeneration and decrease in nutrient diffusion to the intervertebral discs. , 2011, Medical hypotheses.

[53]  A. Minami,et al.  Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits. , 2011, Arthritis and rheumatism.

[54]  L. Dai,et al.  Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats , 2011, Apoptosis.

[55]  J. Manson,et al.  Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. , 2011, JAMA.

[56]  A. Minami,et al.  Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl‐2 overexpression , 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[57]  J. Griffith,et al.  Effect of menopause on lumbar disk degeneration: potential etiology. , 2010, Radiology.

[58]  T. Saito,et al.  GRIP1 enhances estrogen receptor alpha-dependent extracellular matrix gene expression in chondrogenic cells. , 2010, Osteoarthritis and cartilage.

[59]  A. Hofman,et al.  The Association Between Lumbar Disc Degeneration and Low Back Pain: The Influence of Age, Gender, and Individual Radiographic Features , 2010, Spine.

[60]  J. Studd Ten reasons to be happy about hormone replacement therapy: a guide for patients , 2010, Menopause international.

[61]  A. Ahuja,et al.  Reduced bone perfusion in osteoporosis: likely causes in an ovariectomy rat model. , 2010, Radiology.

[62]  Heather Ting Ma,et al.  Relationship between gender, bone mineral density, and disc degeneration in the lumbar spine: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system , 2010, Osteoporosis International.

[63]  J. Calleja-Agius,et al.  Estrogens and the intervertebral disc , 2009, Menopause international.

[64]  J. Niinimäki,et al.  Prevalence of Degenerative Imaging Findings in Lumbar Magnetic Resonance Imaging Among Young Adults , 2009, Spine.

[65]  J. Heino,et al.  Integrins during evolution: evolutionary trees and model organisms. , 2009, Biochimica et biophysica acta.

[66]  David S. Harburger,et al.  Integrin signalling at a glance , 2009, Journal of Cell Science.

[67]  N Bogduk,et al.  The pathophysiology of disc degeneration: a critical review. , 2008, The Journal of bone and joint surgery. British volume.

[68]  P. Prithvi Raj,et al.  Intervertebral Disc: Anatomy‐Physiology‐Pathophysiology‐Treatment , 2008, Pain practice : the official journal of World Institute of Pain.

[69]  L. Dai,et al.  The cell biology of intervertebral disc aging and degeneration , 2007, Ageing Research Reviews.

[70]  V. Podichetty The aging spine: the role of inflammatory mediators in intervertebral disc degeneration. , 2007, Cellular and molecular biology.

[71]  A. Freemont,et al.  Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration , 2007, Arthritis research & therapy.

[72]  E. Hohenester,et al.  Mammalian collagen receptors. , 2007, Matrix biology : journal of the International Society for Matrix Biology.

[73]  E. Oger,et al.  Hormone Therapy and Venous Thromboembolism Among Postmenopausal Women: Impact of the Route of Estrogen Administration and Progestogens: The ESTHER Study , 2007, Circulation.

[74]  M. Brincat,et al.  Low intervertebral disc height in postmenopausal women with osteoporotic vertebral fractures compared to hormone-treated and untreated postmenopausal women and premenopausal women without fractures , 2007, Climacteric : the journal of the International Menopause Society.

[75]  L. Dai,et al.  Programmed cell death in intervertebral disc degeneration , 2006, Apoptosis.

[76]  P. Roughley,et al.  Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration. , 2006, Matrix biology : journal of the International Society for Matrix Biology.

[77]  Robert J. Moore,et al.  The vertebral endplate: disc degeneration, disc regeneration , 2006, European Spine Journal.

[78]  K. Olmarker,et al.  Production of tumor necrosis factor-alpha from porcine nucleus pulposus cells at various time points in cell culture under conditions of nutritional deficiency. , 2006, Cytokine.

[79]  Sally Roberts,et al.  Histology and pathology of the human intervertebral disc. , 2006, The Journal of bone and joint surgery. American volume.

[80]  H. Vanharanta,et al.  Growth factor expression in degenerated intervertebral disc tissue , 2006, European Spine Journal.

[81]  M. Brincat,et al.  Intervertebral disc height in treated and untreated overweight post-menopausal women. , 2005, Human reproduction.

[82]  D. Anderson,et al.  Molecular pathogenic factors in symptomatic disc degeneration. , 2005, The spine journal : official journal of the North American Spine Society.

[83]  P. Roughley,et al.  Tumor Necrosis Factor&agr; Modulates Matrix Production and Catabolism in Nucleus Pulposus Tissue , 2005, Spine.

[84]  K. Olmarker,et al.  Disc Related Cytokines Inhibit Axonal Outgrowth From Dorsal Root Ganglion Cells In Vitro , 2005, Spine.

[85]  K. Ha,et al.  Expression of Estrogen Receptor of the Facet Joints in Degenerative Spondylolisthesis , 2005, Spine.

[86]  N. Boos,et al.  Expression and Distribution of Tumor Necrosis Factor Alpha in Human Lumbar Intervertebral Discs: A Study in Surgical Specimen and Autopsy Controls , 2005, Spine.

[87]  Ian A. F. Stokes,et al.  Mechanical Conditions That Accelerate Intervertebral Disc Degeneration: Overload Versus Immobilization , 2004, Spine.

[88]  Safdar N. Khan,et al.  The molecular basis of intervertebral disk degeneration. , 2003, The Orthopedic clinics of North America.

[89]  S. Suzuki,et al.  Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs. , 2003, Journal of neurosurgery.

[90]  J. Fitzpatrick,et al.  Spontaneous Production of Monocyte Chemoattractant Protein-1 and Interleukin-8 by the Human Lumbar Intervertebral Disc , 2002, Spine.

[91]  S. Jang,et al.  mRNA Expression of Cytokines and Chemokines in Herniated Lumbar Intervertebral Discs , 2002, Spine.

[92]  J. Fitzpatrick,et al.  Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. , 2002, The Journal of bone and joint surgery. British volume.

[93]  Timothy A. Miller,et al.  Expression and localization of estrogen receptor-β in annulus cells of the human intervertebral disc and the mitogenic effect of 17-β-estradiol in vitro , 2002, BMC musculoskeletal disorders.

[94]  N. Matsui,et al.  Influence of Macrophage Infiltration of Herniated Disc Tissue on the Production of Matrix Metalloproteinases Leading to Disc Resorption , 2001, Spine.

[95]  T. Rytömaa,et al.  Transforming growth factor β receptor induction in herniated intervertebral disc tissue: an immunohistochemical study , 2001, European Spine Journal.

[96]  Jong-Beom Park,et al.  Expression of Fas Receptor on Disc Cells in Herniated Lumbar Disc Tissue , 2001, Spine.

[97]  G. Pelletier Localization of androgen and estrogen receptors in rat and primate tissues. , 2000, Histology and histopathology.

[98]  H. Miyamoto,et al.  The role of cyclooxygenase-2 and inflammatory cytokines in pain induction of herniated lumbar intervertebral disc. , 2000, The Kobe journal of medical sciences.

[99]  E Viikari-Juntura,et al.  Low back pain in relation to lumbar disc degeneration. , 2000, Spine.

[100]  D. Herrington,et al.  The ERA trial: findings and implications for the future , 2000, Climacteric : the journal of the International Menopause Society.

[101]  P. Rochon,et al.  The prevalence of low back pain in the elderly. A systematic review of the literature. , 1999, Spine.

[102]  K. Olmarker,et al.  Tumor Necrosis Factor α and Nucleus‐Pulposus‐Induced Nerve Root Injury , 1998 .

[103]  S. Rotshenker,et al.  Murine Nucleus Pulposus‐Derived Cells Secrete Interleukins‐1‐β, ‐6, and ‐10 and Granulocyte‐Macrophage Colony‐Stimulating Factor in Cell Culture , 1997, Spine.

[104]  K. Mizuno,et al.  Immunohistologic Study of the Ruptured Intervertebral Disc of the Lumbar Spine , 1996, Spine.

[105]  T. Kakiuchi,et al.  Inflammatory Cytokines in the Herniated Disc of the Lumbar Spine , 1996, Spine.

[106]  James D. Kang,et al.  Herniated Cervical Intervertebral Discs Spontaneously Produce Matrix Metalloproteinases, Nitric Oxide, Interleukin‐6, and Prostaglandin E2 , 1995, Spine.

[107]  K. Yonenobu,et al.  Distribution of the Basic Fibroblast Growth Factor and Its Receptor Gene Expression in Normal and Degenerated Rat Intervertebral Discs , 1995, Spine.

[108]  J A Buckwalter,et al.  Aging and degeneration of the human intervertebral disc. , 1995, Spine.

[109]  T. Rytömaa,et al.  Basic Fibroblast Growth Factor Immunoreactivity in Blood Vessels and Cells of Disc Herniations , 1995, Spine.

[110]  H. Matsui,et al.  Oophorectomy predisposes to degenerative spondylolisthesis. , 1995, The Journal of bone and joint surgery. British volume.

[111]  Nicholas,et al.  Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. , 1990, The Journal of bone and joint surgery. American volume.

[112]  S Holm,et al.  Nutrition of the intervertebral disc: effect of fluid flow on solute transport. , 1982, Clinical orthopaedics and related research.

[113]  S. Eisenstein,et al.  Biochemical changes in intervertebral disc degeneration. , 1981, Biochimica et biophysica acta.

[114]  S Holm,et al.  Nutrition of the intervertebral disc: solute transport and metabolism. , 1981, Connective tissue research.

[115]  A. Maroudas,et al.  Diffusion of small solutes into the intervertebral disc: as in vivo study. , 1978, Biorheology.

[116]  S Holm,et al.  Nutrition of the intervertebral disk. An in vivo study of solute transport. , 1977, Clinical orthopaedics and related research.

[117]  Thompson Ea,et al.  Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione. , 1974 .

[118]  E. A. Thompson,et al.  Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione. , 1974, The Journal of biological chemistry.

[119]  A. Nachemson,et al.  In vitro diffusion of dye through the end-plates and the annulus fibrosus of human lumbar inter-vertebral discs. , 1970, Acta orthopaedica Scandinavica.

[120]  R. Dorfman,et al.  The intermediate steps in the biosynthesis of estrogens from androgens. , 1961, Biochemical and biophysical research communications.