Isolation of Marek's disease virus from Japanese quail with lymphoproliferative disease.

Sixty-one Japanese quail from eight flocks with problems of recurring outbreaks of lymphoproliferative diseases resembling Marek's disease (MD), were examined aetiologically. Gross lymphomatous lesions were seen in 17 of the quail and 11 out of 56 quail had MD virus (MDV) feather tips antigens. MDV antibody was detectable in only one of 22 quail. None of 9 quail had antibodies against reticuloendotheliosis virus (REV). No MDV was isolated from the total 42 materials of quail using cell culture technique. No REV and avian leukosis virus (ALV) were isolated from some of them. However, specific-pathogen-free chicks inoculated with the blood materials revealed MD. and four MDVs were recovered from them. The isolates proved free from REV and ALV. The isolates were placed into serotype 1 by the indirect immunofluorescent antibody test. These results indicate that MDV is aetiologically involved in the present outbreaks of lymphoproliferative disease in Japanese quail.

[1]  T. Mikami,et al.  A study of Marek's disease in Japanese quails vaccinated with herpesvirus of turkeys. , 1986, Avian diseases.

[2]  K. Tsukamoto,et al.  An enzyme-linked immunosorbent assay for detection of antibodies to exogenous avian leukosis virus. , 1985, Avian diseases.

[3]  H. K. Pradhan,et al.  Marek's disease in Japanese quails (Coturnix coturnix japonica): a study of natural cases. , 1985, Avian diseases.

[4]  M. Rennie,et al.  The expression of Marek's disease tumour-associated surface antigen in various avian species. , 1984, Avian pathology : journal of the W.V.P.A.

[5]  L. Lee,et al.  Monoclonal antibodies with specificity for three different serotypes of Marek's disease viruses in chickens. , 1983, Journal of immunology.

[6]  Cho Br.  A simple in vitro differentiation between turkey herpesvirus and Marek's disease virus. , 1981 .

[7]  H. Hihara,et al.  Oncogenicity of three strains of avian leukosis virus in White Leghorn chicks of BK line. , 1980, National Institute of Animal Health quarterly.

[8]  T. Taniguchi,et al.  Isolation and some characteristics of an agent inducing anemia in chicks. , 1979 .

[9]  K. Schat,et al.  Characterization of an apparently nononcogenic Marek's disease virus. , 1978, Journal of the National Cancer Institute.

[10]  M. Lai,et al.  Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail , 1977, Cell.

[11]  K. Schat,et al.  A lymphoproliferative disease in Japanese Quail. , 1976, Avian diseases.

[12]  T. Taniguchi,et al.  Isolation of a reticuloendotheliosis virus from chickens inoculated with Marek's disease vaccine. , 1976, National Institute of Animal Health quarterly.

[13]  J. Grun,et al.  Marek's disease in Japanese quail -- a pathological, virological and serological study. , 1975, Poultry science.

[14]  K. Okada,et al.  Pathological studies of Marek's disease in Japanese quail. , 1975, The Japanese journal of veterinary research.

[15]  K. Okada,et al.  Pathogenic and serologic studies of Japanese quail infected with JM strain of Marek's disease herpesvirus. , 1975, Journal of the National Cancer Institute.

[16]  P. Biggs,et al.  Differentiation between strains of Marek's disease virus and turkey herpesvirus by immunofluorescence assays. , 1975, Avian pathology : journal of the W.V.P.A.

[17]  H. C. Carlson,et al.  Reticuloendotheliosis in Japanese quail. , 1974, Avian pathology : journal of the W.V.P.A.

[18]  Robinson Fr,et al.  Isolation of tha avian reticuloendothelial virus (strain T). , 1974 .

[19]  W. Becker,et al.  Marek's disease in the Japanese quail (Coturnix coturnix japonica). , 1973, Poultry science.

[20]  R. Witter,et al.  Peripheral nerve lesions similar to those of Marek's disease in chickens inoculated with reticuloendotheliosis virus. , 1970, Journal of the National Cancer Institute.

[21]  R. Witter,et al.  Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek's disease virus. , 1970, American journal of veterinary research.

[22]  Cho Br,et al.  Transmission of classical Marek's disease by affected and carrier birds. , 1969 .

[23]  R. Witter,et al.  Cell culture techniques for primary isolation of Marek's disease-associated herpesvirus. , 1969, Avian diseases.

[24]  Eidson Cs,et al.  Studies on acute Marek's disease. I. Characteristics of isolate GA in chickens. , 1968 .

[25]  H. Kawamura,et al.  Propagation and cytopathic effect of Myxovirus yucaipa in chicken kidney cell culture. , 1968, National Institute of Animal Health quarterly.

[26]  P. Biggs,et al.  Agent of Marek's Disease in Tissue Culture , 1967, Nature.

[27]  R. Zeigel,et al.  Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. , 1966, Journal of the National Cancer Institute.

[28]  I. K. Berezesky,et al.  Immunofluorescent studies of group-specific antigen of the avian sarcoma-leukosis viruses. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[29]  H. Rubin,et al.  A VIRUS IN CHICK EMBRYOS WHICH INDUCES RESISTANCE IN VITRO TO INFECTION WITH ROUS SARCOMA VIRUS. , 1960, Proceedings of the National Academy of Sciences of the United States of America.