Detection of Schizophrenia Spectrum Disorders Using Saliency Maps

Modern medical diagnostic systems have greatly contributed to the increase in survival rate of patients suffering from illnesses and to lengthening of average lifespan. Some diagnostic devices, such as Magnetic Resonance, can detect illnesses that may not exhibit any symptoms yet and medical diagnostic equipment can furthermore significantly aid in confirmation of suspected, otherwise undetectable diagnoses. One of the medical fields lacking automated diagnostic tools is psychopathology, where a mental disorder presence is typically established from observations of classified symptoms and structured systematic interviews. The goal of our paper was to design and test a reliable and automated diagnostic method for detection of Schizophrenia spectrum disorders. The proposed method utilizes eye-tracker and Rorschach Inkblot Test to create a visual attention saliency map of observed subjects. These maps are then processed and analyzed using Digital Image Processing and statistical methods to determine, whether the subject exhibits signs of schizophrenia or not. The proposed approach is based on a trained classifier which separates incoming data into either healthy or schizophrenic patients. Of course, these results are only indicative and the final diagnosis rests in the hands of qualified specialists. High correlation of the proposed system, s diagnosis and real clinical diagnosis however proves applicability of the proposed concepts as reliable supplementary tool for Schizophrenia detection.

[1]  Martin D. Levine,et al.  Visual Saliency Based on Scale-Space Analysis in the Frequency Domain , 2013, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[2]  G. Pearlson,et al.  Eye Movements and Psychopathology in Schizophrenia and Bipolar Disorder , 1996, The Journal of nervous and mental disease.

[3]  Ali N. Akansu,et al.  Factorization of the coefficient variance matrix in orthogonal transforms , 1991, IEEE Trans. Signal Process..

[4]  Volker Arolt,et al.  Schizophrenia spectrum disorders and eye tracking dysfunction in singleton and multiplex schizophrenia families , 2003, Schizophrenia Research.

[5]  Paul A Wetzel,et al.  Pervasive ocular tremor in patients with Parkinson disease. , 2012, Archives of neurology.

[6]  R. R. Blake,et al.  Ocular activity during administration of the Rorschach test. , 1948, Journal of clinical psychology.

[7]  S. Lal,et al.  Stability of exploratory eye movements as a marker of schizophrenia — a WHO multi-center study , 2001, Schizophrenia Research.

[8]  Philip C. Ko,et al.  Eye movements in Alzheimer's disease. , 2015, Journal of Alzheimer's disease : JAD.

[9]  A. Srivastava,et al.  Saccadic eye movements in Parkinson's disease , 2014, Indian journal of ophthalmology.

[10]  Harold H. Greene,et al.  Here’s Looking at You , 2012 .

[11]  P. Benson,et al.  Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy , 2012, Biological Psychiatry.

[12]  Christof Koch,et al.  A Model of Saliency-Based Visual Attention for Rapid Scene Analysis , 2009 .

[13]  Tim J Anderson,et al.  Eye movements in neurodegenerative diseases. , 2016, Current opinion in neurology.

[14]  Elizeu Coutinho de Macedo,et al.  Analysis of exploratory eye movements in patients with schizophrenia during visual scanning of projective tests' figures , 2010 .

[15]  Keith Jones The Regularized Fast Hartley Transform , 2010 .

[16]  S. Martinez-Conde,et al.  Distinctive features of microsaccades in Alzheimer’s disease and in mild cognitive impairment , 2014, AGE.

[17]  Thierry Baccino,et al.  Methods for comparing scanpaths and saliency maps: strengths and weaknesses , 2012, Behavior Research Methods.

[18]  Lucas Paletta,et al.  Visual recovery of saliency maps from human attention in 3D environments , 2013, 2013 IEEE International Conference on Robotics and Automation.

[19]  Qi Zhao,et al.  Learning saliency-based visual attention: A review , 2013, Signal Process..

[20]  Thierry d'Amato,et al.  Saccadic eye movements in schizophrenic patients , 1998, Psychiatry Research.

[21]  Ali Borji,et al.  Computational models of attention , 2015, ArXiv.

[22]  Daya K. Nagar,et al.  Testing Equality of Several Correlation Matrices , 2013 .

[23]  John K. Miller Science and Pseudoscience in Clinical Psychology , 2005 .