Molecular and Cellular Biology of Moderate-Dose (1–10 Gy) Radiation and Potential Mechanisms of Radiation Protection: Report of a Workshop at Bethesda, Maryland, December 17–18, 20011

Abstract Coleman, C. N., Blakely, W. F., Fike, J. R., MacVittie, T. J., Metting, N. F., Mitchell, J. B., Moulder, J. E., Preston, R. J., Seed, T. M., Stone, H. B., Tofilon, P. J. and Wong, R. S. L. Molecular and Cellular Biology of Moderate-Dose (1–10 Gy) Radiation and Potential Mechanisms of Radiation Protection: Report of a Workshop at Bethesda, Maryland, December 17–18, 2001. Radiat. Res. 159, 812–834 (2003). Exposures to doses of radiation of 1–10 Gy, defined in this workshop as moderate-dose radiation, may occur during the course of radiation therapy or as the result of radiation accidents or nuclear/radiological terrorism alone or in conjunction with bioterrorism. The resulting radiation injuries would be due to a series of molecular, cellular, tissue and whole-animal processes. To address the status of research on these issues, a broad-based workshop was convened. The specific recommendations were: (1) Research: Identify the key molecular, cellular and tissue pathways that lead from the initial molecular lesions to immediate and delayed injury. The latter is a chronic progressive process for which postexposure treatment may be possible. (2) Technology: Develop high-throughput technology for studying gene, protein and other biochemical expression after radiation exposure, and cytogenetic markers of radiation exposure employing rapid and accurate techniques for analyzing multiple samples. (3) Treatment strategies: Identify additional biological targets and develop effective treatments for radiation injury. (4) Ensuring sufficient expertise: Recruit and train investigators from such fields as radiation biology, cancer biology, molecular biology, cellular biology and wound healing, and encourage collaboration on interdisciplinary research on the mechanisms and treatment of radiation injury. Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public.

[1]  I. Emerit,et al.  Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor , 2005, Journal of Cancer Research and Clinical Oncology.

[2]  M. Monje,et al.  Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. , 2003, Cancer research.

[3]  P. Bourin,et al.  Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival. , 2003, Blood.

[4]  R. Kurzrock.  Hematopoietic growth factors in bone marrow failure states , 2003 .

[5]  J. Moulder.  Pharmacological intervention to prevent or ameliorate chronic radiation injuries. , 2003, Seminars in radiation oncology.

[6]  N. Wald,et al.  Management of Terrorist Events Involving Radioactive Material , 2002 .

[7]  Louis B. Harrison,et al.  Prevalence of Anemia in Cancer Patients Undergoing Radiotherapy: Prognostic Significance and Treatment , 2002, Oncology.

[8]  J. Moulder.  Radiobiology of nuclear terrorism: report on an interagency workshop (Bethesda, MD, December 17-18, 2001). , 2002, International Journal of Radiation Oncology, Biology, Physics.

[9]  Tchekmedyian Ns.  Anemia in cancer patients: significance, epidemiology, and current therapy. , 2002, Oncology.

[10]  M. Monje,et al.  Irradiation induces neural precursor-cell dysfunction , 2002, Nature Medicine.

[11]  Andrzej Wojcik,et al.  The Medical Basis for Radiation-Accident Preparedness. The Clinical Care of Victims, Proceedings of the Fourth International REACT/TS Conference on The Medical Basis for Radiation-Accident Preparedness , 2002 .

[12]  J. Moulder.  Report on an Interagency Workshop on the Radiobiology of Nuclear Terrorism , 2002, Radiation research.

[13]  M. Vandamme,et al.  Administration of Recombinant Human IL11 after Supralethal Radiation Exposure Promotes Survival in Mice: Interactive Effect with Thrombopoietin , 2002, Radiation research.

[14]  E. Cohen,et al.  The renin-angiotensin system in experimental radiation nephropathy. , 2002, The Journal of laboratory and clinical medicine.

[15]  C. N. Coleman,et al.  Modifying Normal Tissue Damage Postirradiation , 2002, Radiation research.

[16]  T. Seed,et al.  Nutritional approaches to radioprotection: vitamin E. , 2002, Military medicine.

[17]  A. Farese,et al.  Cytokine-based treatment of radiation injury: potential benefits after low-level radiation exposure. , 2002, Military medicine.

[18]  R. Neta,et al.  Prevention and treatments: summary statement. , 2002, Military Medicine.

[19]  Y. Kataoka,et al.  Relationships between cytoprotection and mutation prevention by WR-1065. , 2002, Military Medicine.

[20]  James B. Mitchell,et al.  Nitroxides as radiation protectors. , 2002, Military medicine.

[21]  I. Brook,et al.  Management of postirradiation sepsis. , 2002, Military medicine.

[22]  D. Frank,et al.  The Synergy Between Stem Cell Factor (SCF) and Granulocyte Colony-stimulating Factor (G-CSF): Molecular Basis and Clinical Relevance , 2002, Leukemia & lymphoma.

[23]  M. B. Grace,et al.  Real-time quantitative RT-PCR assay of GADD45 gene expression changes as a biomarker for radiation biodosimetry , 2002, International journal of radiation biology.

[24]  C. N. Coleman,et al.  MEETING REPORT Modifying Normal Tissue Damage Postirradiation Report of a Workshop Sponsored by the Radiation Research Program , 2002 .

[25]  W. Gerald,et al.  Comparison of normal and tumor cells by laser capture microdissection. , 2002, Methods in Enzymology.

[26]  C. S. Davis,et al.  Radiation-induced kidney injury: a role for chronic oxidative stress? , 2002, Micron.

[27]  J. Redpath,et al.  The Shape of the Dose–Response Curve for Radiation-Induced Neoplastic Transformation In Vitro: Evidence for an Adaptive Response against Neoplastic Transformation at Low Doses of Low-LET Radiation , 2001, Radiation research.

[28]  M. Bittner,et al.  Induction of Gene Expression as a Monitor of Exposure to Ionizing Radiation , 2001, Radiation research.

[29]  M. Barcellos-Hoff,et al.  Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic Instability , 2001, Radiation research.

[30]  P. Okunieff,et al.  Keratinocyte Growth Factors Radioprotect Bowel and Bone Marrow But Not KHT Sarcoma , 2001, American journal of clinical oncology.

[31]  R. Goans,et al.  Early dose assessment in criticality accidents. , 2001, Health physics.

[32]  M. Sasaki,et al.  Cytogenetical dose estimation for 3 severely exposed patients in the JCO criticality accident in Tokai-mura. , 2001, Journal of radiation research.

[33]  A. Brooks.  Biomarkers of exposure and dose: state of the art. , 2001, Radiation protection dosimetry.

[34]  S. Amundson,et al.  Gene expression profiles for monitoring radiation exposure. , 2001, Radiation protection dosimetry.

[35]  M. B. Grace,et al.  Radiation exposure assessment using cytological and molecular biomarkers. , 2001, Radiation protection dosimetry.

[36]  M. Whitnall,et al.  In Vivo Radioprotection by 5-Androstenediol: Stimulation of the Innate Immune System , 2001, Radiation research.

[37]  K. Weinberg,et al.  Radiosensitivity of thymic interleukin-7 production and thymopoiesis after bone marrow transplantation. , 2001, Blood.

[38]  Noelle F. Metting,et al.  Adaptive Response and the Bystander Effect Induced by Radiation in C3H 10T½ Cells in Culture , 2001, Radiation research.

[39]  R. Clough,et al.  Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta. , 2001, International journal of radiation oncology, biology, physics.

[40]  L. Oberley,et al.  Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation. , 2001, Cancer research.

[41]  Zvi Fuks,et al.  Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice , 2001, Science.

[42]  C. Muirhead.  Cancer after nuclear incidents , 2001, Occupational and environmental medicine.

[43]  D. Hallahan,et al.  Activation of NFκB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells , 2001 .

[44]  C. Dunbar,et al.  The Impact of ex Vivo Cytokine Stimulation on Engraftment of Primitive Hematopoietic Cells in a Non‐Human Primate Model , 2001, Annals of the New York Academy of Sciences.

[45]  R. Schmidt-Ullrich,et al.  Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. , 2001, Cancer research.

[46]  M. Cornforth,et al.  Complex Chromosome Exchanges Induced by Gamma Rays in Human Lymphocytes: An mFISH Study , 2001, Radiation research.

[47]  F. Mettler,et al.  Treatment of Acute Radiation Sickness , 2001 .

[48]  G. Voelz.  Assessment and Treatment of Internal Contamination: General Principles , 2001 .

[49]  E. Gould,et al.  Neurogenesis in the adult is involved in the formation of trace memories , 2001, Nature.

[50]  J. Bussel,et al.  A pilot study of rhuIL‐11 treatment of refractory ITP , 2001, American journal of hematology.

[51]  P. Okunieff,et al.  Circulating IL-6 as a predictor of radiation pneumonitis. , 2001, International journal of radiation oncology, biology, physics.

[52]  D. Brenner,et al.  The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ Cells In Vitro can be Initiated in the Unirradiated Neighbors of Irradiated Cells , 2001, Radiation research.

[53]  J. Bayani,et al.  Advances in the detection of chromosomal aberrations using spectral karyotyping , 2001, Clinical genetics.

[54]  J. Little,et al.  Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[55]  W. Dörr,et al.  Modification of oral mucositis by keratinocyte growth factor: single radiation exposure , 2001, International journal of radiation biology.

[56]  D. Liggitt,et al.  Modulation of Radiation-Induced Cytokine Elevation Associated with Esophagitis and Esophageal Stricture by Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Gene Therapy , 2001, Radiation research.

[57]  C. Spencer,et al.  Amifostine , 2012, Drugs.

[58]  G. Xiong,et al.  [The effect of rhIL-11 on hematopoiesis of rhesus monkeys irradiated with 60Co gamma-rays]. , 2001, Zhonghua zhong liu za zhi [Chinese journal of oncology].

[59]  B. Vikram,et al.  Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[60]  Arthur H. Heiss,et al.  Individual biodosimetry at the natural radiation background level. , 2001, Health physics.

[61]  M. Kaplan,et al.  Is liver fibrosis reversible? , 2001, The New England journal of medicine.

[62]  P. Uma Devi,et al.  Radiation Protection by the Ocimum Flavonoids Orientin and Vicenin: Mechanisms of Action , 2000, Radiation research.

[63]  Sally A. Amundson,et al.  Identification of Potential mRNA Biomarkers in Peripheral Blood Lymphocytes for Human Exposure to Ionizing Radiation , 2000, Radiation research.

[64]  C. Reynolds.  Clinical efficacy of rhIL-11. , 2000, Oncology.

[65]  D A Pierce,et al.  Radiation-Related Cancer Risks at Low Doses among Atomic Bomb Survivors , 2000, Radiation research.

[66]  J. Fike,et al.  X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats , 2000, Neuroscience.

[67]  D. Boothman,et al.  Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[68]  D. Lloyd,et al.  The role of cytogenetics in early triage of radiation casualties. , 2000, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[69]  Carmel Mothersill,et al.  Relative Contribution of Bystander and Targeted Cell Killing to the Low-Dose Region of the Radiation Dose–Response Curve , 2000, Radiation research.

[70]  J. Iredale,et al.  Is liver fibrosis reversible? , 2000, Gut.

[71]  J. Fike,et al.  The Radioresponse of the Central Nervous System: A Dynamic Process , 2000, Radiation research.

[72]  P. Prasanna,et al.  Induction of premature chromosome condensation by a phosphatase inhibitor and a protein kinase in unstimulated human peripheral blood lymphocytes: a simple and rapid technique to study chromosome aberrations using specific whole-chromosome DNA hybridization probes for biological dosimetry. , 2000, Mutation research.

[73]  M. Barcellos-Hoff,et al.  Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. , 2000, Cancer research.

[74]  E. Hall,et al.  Induction of a bystander mutagenic effect of alpha particles in mammalian cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[75]  D. Boothman,et al.  Coordinate modulation of Sp1, NF‐kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[76]  James B. Mitchell,et al.  Radiation, Radicals, and Images , 2000, Annals of the New York Academy of Sciences.

[77]  D. Goodhead,et al.  Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alpha-particles. , 2000, International journal of radiation biology.

[78]  N. Russell,et al.  Allogeneic haemopoietic stem cell transplantation for multiple myeloma or plasma cell leukaemia using fractionated total body radiation and high-dose melphalan conditioning. , 2000, Acta oncologica.

[79]  Y. Kataoka,et al.  Amifostine: Mechanisms of Action Underlying Cytoprotection and Chemoprevention , 2000, Drug metabolism and drug interactions.

[80]  J. M. Taylor,et al.  Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. , 2000, International journal of radiation biology.

[81]  R. Loria,et al.  Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice. , 2000, International journal of immunopharmacology.

[82]  D. Jarrett.  Medical Management of Radiological Casualties Handbook. First Edition , 1999 .

[83]  J. Fike,et al.  Long-Term Impairment of Subependymal Repopulation Following Damage by Ionizing Irradiation , 1999, Experimental Neurology.

[84]  A. Rosenberg,et al.  Antigen presentation determines the fate of the T memory response in vivo after sublethal gamma-irradiation. , 1999, Journal of immunology.

[85]  E. Winer,et al.  American Society of Clinical Oncology clinical practice guidelines for the use of chemotherapy and radiotherapy protectants. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[86]  J. Lefaix,et al.  Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[87]  D. Boreham,et al.  The adaptive response modifies latency for radiation-induced myeloid leukemia in CBA/H mice. , 1999, Radiation research.

[88]  S. Bellucci,et al.  Regulation of Megakaryocytopoiesis , 1999, Pathophysiology of Haemostasis and Thrombosis.

[89]  A. Fornace,et al.  Induction of stress genes by low doses of gamma rays. , 1999, Radiation research.

[90]  O. Ottmann,et al.  Megakaryocytic growth factors: is there a new approach for management of thrombocytopenia in patients with malignancies? , 1999, Leukemia.

[91]  S. Singhal,et al.  Reimmunization after blood or marrow stem cell transplantation , 1999, Bone Marrow Transplantation.

[92]  D. Lloyd,et al.  Easy biodosimetry for high-dose radiation exposures using drug-induced, prematurely condensed chromosomes. , 1999, International journal of radiation biology.

[93]  F. W. Whicker,et al.  Radioactive contamination: state of the science and its application to predictive models. , 1999, Environmental pollution.

[94]  D. Lacey,et al.  Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice. , 1999, International journal of radiation biology.

[95]  D. Hoelzer,et al.  Megakaryocytic growth factors: is there a new approach for management of thrombocytopenia in patients with malignancies? , 1999, Leukemia.

[96]  S. Yeh,et al.  Isolation of Ku70-binding proteins (KUBs). , 1999, Nucleic acids research.

[97]  K M Prise,et al.  Studies of bystander effects in human fibroblasts using a charged particle microbeam. , 1998, International journal of radiation biology.

[98]  M. Barcellos-Hoff,et al.  How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. , 1998, Radiation research.

[99]  C. Potten,et al.  The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine. , 1998, British Journal of Cancer.

[100]  A. Gratwohl,et al.  FLT-3 ligand provides hematopoietic protection from total body irradiation in rabbits. , 1998, Blood.

[101]  J. Kaye.  FDA licensure of neumega® to prevent severe chemotherapy‐induced thrombocytopenia , 1998, Stem cells.

[102]  G. Wagemaker,et al.  The efficacy of recombinant tpo in murine and nonhuman primate models for myelosuppression and stem cell transplantation , 1998, Stem cells.

[103]  C. Mothersill,et al.  Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium. , 1998, Radiation research.

[104]  D. Lacey,et al.  Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. , 1998, Cancer research.

[105]  P. Zorat,et al.  [Use of filgrastim, granulocyte colony stimulating factor (G-CSF), in radiotherapy to reduce drop-outs because of radiogenic leukopenia]. , 1998, La Radiologia medica.

[106]  E. Cohen,et al.  Radiation nephropathy is treatable with an angiotensin converting enzyme inhibitor or an angiotensin II type-1 (AT1) receptor antagonist. , 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[107]  S. Wolff.  The adaptive response in radiobiology: evolving insights and implications. , 1998, Environmental health perspectives.

[108]  R. Komaki,et al.  Integration of filgrastim into chemoradiation for limited small cell lung cancer: a Phase I study. , 1998, International journal of radiation oncology, biology, physics.

[109]  M. Durante,et al.  A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. , 1998, International journal of radiation biology.

[110]  J. Greenberger,et al.  Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy , 1998, Gene Therapy.

[111]  J. Wagner,et al.  Placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation. , 1997, Blood.

[112]  N. Robert,et al.  Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin. , 1997, Journal of Clinical Oncology.

[113]  J. Fike,et al.  Apoptosis in the subependyma of young adult rats after single and fractionated doses of X-rays. , 1997, Cancer research.

[114]  D Followill,et al.  Estimates of whole-body dose equivalent produced by beam intensity modulated conformal therapy. , 1997, International journal of radiation oncology, biology, physics.

[115]  P. Prasanna,et al.  Premature chromosome condensation assay for biodosimetry: studies with fission-neutrons. , 1997, Health physics.

[116]  T. Nagasawa,et al.  Regulation of megakaryocytopoiesis by thrombopoietin and stromal cells. , 1997, Leukemia.

[117]  R C Ricks,et al.  Early dose assessment following severe radiation accidents. , 1997, Health physics.

[118]  W. Nothdurft,et al.  Acceleration of hemopoietic recovery in dogs after extended-field partial-body irradiation by treatment with colony-stimulating factors: rhG-CSF and rhGM-CSF. , 1997, International journal of radiation oncology, biology, physics.

[119]  J. Harrison.  Advances in the Treatment of Radiation Injuries , 1997 .

[120]  R. Ullrich,et al.  Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: the difference is as clear as black and white. , 1997, Radiation research.

[121]  D. Lacey,et al.  Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. , 1997, Cancer research.

[122]  I. Emerit,et al.  Clastogenic factors in the plasma of children exposed at Chernobyl. , 1997, Mutation research.

[123]  A. Begg,et al.  Detection of radiation-induced chromosome aberrations using fluorescence in situ hybridization in drug-induced premature chromosome condensations of tumour cell lines with different radiosensitivities. , 1997, International journal of radiation biology.

[124]  C. Mothersill,et al.  Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. , 1997, International journal of radiation biology.

[125]  T. Ulich,et al.  Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. , 1996, The American journal of pathology.

[126]  P. Okunieff,et al.  Cytokine-Induced Radiation Protection and Sensitization. , 1996, Seminars in radiation oncology.

[127]  R. Ullrich,et al.  Strain-dependent susceptibility to radiation-induced mammary cancer is a result of differences in epithelial cell sensitivity to transformation. , 1996, Radiation research.

[128]  K. Weinberg,et al.  Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. , 1996, Blood.

[129]  A. Pedro,et al.  Prevention of radioinduced cystitis by orgotein: a randomized study. , 1996, Anticancer research.

[130]  F. Baillet,et al.  Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study. , 1996, International journal of radiation oncology, biology, physics.

[131]  D. Browne,et al.  Advances in the treatment of radiation injuries : proceedings of the 2nd Concensus Development Conference on the Treatment of Radiation Injuries, held in Bethesda, Maryland, USA on 14-17 April 1993 , 1996 .

[132]  Martyn T. Smith,et al.  Use of the fluorescent micronucleus assay to detect the genotoxic effects of radiation and arsenic exposure in exfoliated human epithelial cells , 1996, Environmental and molecular mutagenesis.

[133]  A. Diehl.  Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract: Housley RM, Morris CF, Boyle W, Ring B, Biltz R, Tarpley JE, Aukerman SL, et al. J Clin Invest 1994; 94: 1764–1777 , 1995 .

[134]  D. Lacey,et al.  Keratinocyte growth factor causes proliferation of urothelium in vivo. , 1995, The Journal of urology.

[135]  E. Hall,et al.  Photoneutrons from medical linear accelerators--radiobiological measurements and risk estimates. , 1995, International journal of radiation oncology, biology, physics.

[136]  D. Danilenko,et al.  Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. , 1995, The American journal of pathology.

[137]  J. Armitage,et al.  Clinical applications of hematopoietic growth factors. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[138]  K. Kamiya,et al.  Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[139]  D. Roman,et al.  Neuropsychological effects of cranial radiation: current knowledge and future directions. , 1995, International journal of radiation oncology, biology, physics.

[140]  S. Jacobsen,et al.  Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7 , 1995, The Journal of experimental medicine.

[141]  R. Whitehead,et al.  Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. , 1994, The Journal of clinical investigation.

[142]  W. A. Jennings.  Quantities and units in radiation protection dosimetry , 1994 .

[143]  F. Baillet,et al.  Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: clinical trial. , 1994, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[144]  R. Yalow.  Concerns with low-level ionizing radiation. , 1994, Mayo Clinic proceedings.

[145]  M. Kovacs,et al.  Visualization of nonreciprocal chromosome exchanges in irradiated human fibroblasts by fluorescence in situ hybridization. , 1993, Radiation research.

[146]  M. Meyers,et al.  Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[147]  A. Brooks,et al.  Metaphase chromosome aberrations as markers of radiation exposure and dose. , 1993, Journal of toxicology and environmental health.

[148]  J. Little,et al.  Induction of sister chromatid exchanges by extremely low doses of alpha-particles. , 1992, Cancer research.

[149]  K. Zsebo,et al.  Radioprotection of mice by recombinant rat stem cell factor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[150]  S. O’Brien,et al.  Emergence of the keratinocyte growth factor multigene family during the great ape radiation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[151]  S. Hahn,et al.  Tempol, a stable free radical, is a novel murine radiation protector. , 1992, Cancer research.

[152]  J. Weiss,et al.  Radioprotection by vitamin E: injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice. , 1992, International journal of radiation oncology, biology, physics.

[153]  S. Hahn,et al.  Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol. , 1991, Archives of biochemistry and biophysics.

[154]  J. Kurtzberg,et al.  Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. , 1989, The New England journal of medicine.

[155]  Henry I. Kohn,et al.  Sources, Effects and Risks of Ionizing Radiation , 1989 .

[156]  S. J. Baum,et al.  Symptomatology of acute radiation effects in humans after exposure to doses of 0.5-30 Gy. , 1989, Health physics.

[157]  D. Boothman,et al.  Identification and characterization of X-ray-induced proteins in human cells. , 1989, Cancer research.

[158]  M. Bender,et al.  Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. , 1988, Mutation research.

[159]  M. Griem.  Neutron Contamination From Medical Electron Accelerators , 1985 .

[160]  J. Bedford,et al.  On the nature of a defect in cells from individuals with ataxia-telangiectasia. , 1985, Science.

[161]  G. Pantelias,et al.  Direct analysis of radiation-induced chromosome fragments and rings in unstimulated human peripheral blood lymphocytes by means of the premature chromosome condensation technique. , 1985, Mutation research.

[162]  K. Baverstock.  The LD50 for uniform low LET irradiation of man. , 1985, The British journal of radiology.

[163]  S. Wolff,et al.  Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. , 1984, Science.

[164]  J. Bedford,et al.  X-ray--induced breakage and rejoining of human interphase chromosomes. , 1983, Science.

[165]  W. Russell,et al.  Specific-locus mutation frequencies in mouse stem-cell spermatogonia at very low radiation dose rates. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[166]  T. R. Sweeney.  A Survey of Compounds from the Antiradiation Drug Development Program of the U.S. Army Medical Research and Development Command , 1979 .

[167]  J. Little,et al.  Protease inhibitors suppress radiation-induced malignant transformation in vitro , 1978, Nature.

[168]  N. Kamada,et al.  Chromosome aberrations in normal leukocytes induced by the plasma of exposed individuals. , 1977, Hiroshima journal of medical sciences.

[169]  J. Deye,et al.  TECHNICAL NOTE: Neutron production from a 10 MV medical line , 1977 .

[170]  Goh K-O.  Total-body irradiation and human chromosomes. V. Additional evidence of a transferable substance in the plasma of irradiated persons to induce chromosomal breakages. , 1975 .

[171]  W. Hittelman,et al.  Premature chromosome condensation. I. Visualization of x-ray-induced chromosome damage in interphase cells. , 1974, Mutation research.

[172]  R. Johnson,et al.  Analysis of interphase chromosome damage by means of premature chromosome condensation after X- and ultraviolet-irradiation. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[173]  P. N. Rao,et al.  Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei , 1970, Nature.

[174]  J. Hollowell,et al.  Chromosome Damage Induced by Plasma of X-Rayed Patients , 1968, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.