[Clinical analysis of 164 cases Coombs test positive autoimmune hemolytic anemia].

OBJECTIVE To analyze the clinical features and treatment outcomes of autoimmune hemolytic anemia (AIHA). METHODS Coombs test positive AIHA patients were retrospectively analyzed. RESULTS Patients with AIHA were predominantly female, secondary AIHA accounted for 49% of the total cases, mainly associated with connective tissue diseases. In most cases of AIHA, the anti-red cell antibodies were IgG plus C3, while patients with IgG plus IgM had more severe clinical manifestations. The response rate of adrenocortical hormones and cyclosporin A (CsA) was 90.9%. CONCLUSION Adrenocorticosteroids is still the first choice of therapy for AIHA, CsA can improve the response rate.