Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat

[1]  K. Jin,et al.  Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat , 2014, Journal of Neuroinflammation.

[2]  H. Hartung,et al.  Macrophages prevent hemorrhagic infarct transformation in murine stroke models , 2012, Annals of neurology.

[3]  M. Horton,et al.  Regulation of immune responses by mTOR. , 2012, Annual review of immunology.

[4]  Weiguang Zhang,et al.  Mammalian target of rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in canines , 2012, Experimental Neurology.

[5]  J. Grotta,et al.  IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways , 2011, Brain Research.

[6]  Lloyd A Greene,et al.  Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease , 2010, The Journal of Neuroscience.

[7]  Pierluigi Navarra,et al.  Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation. , 2009, Biochemical pharmacology.

[8]  É. Mezey,et al.  Transforming growth factor α induces angiogenesis and neurogenesis following stroke , 2009, Neuroscience.

[9]  L. Chodosh,et al.  mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. , 2009, Cell stem cell.

[10]  L. Zeng,et al.  The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy , 2009, The Journal of Neuroscience.

[11]  D. Littman,et al.  Plasticity of CD4+ T cell lineage differentiation. , 2009, Immunity.

[12]  A. Rudensky,et al.  Control of regulatory T cell lineage commitment and maintenance. , 2009, Immunity.

[13]  Christian Gerloff,et al.  Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. , 2009, Stroke.

[14]  J. Blenis,et al.  Molecular mechanisms of mTOR-mediated translational control , 2009, Nature Reviews Molecular Cell Biology.

[15]  C. Betsholtz,et al.  Endothelial-mural cell signaling in vascular development and angiogenesis. , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[16]  C. Sommer,et al.  Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke , 2009, Nature Medicine.

[17]  G. Buonocore,et al.  Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury , 2008, Neurobiology of Disease.

[18]  Tianhong Pan,et al.  Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement , 2008, Neurobiology of Disease.

[19]  G. de la Rosa,et al.  Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. , 2007, International immunopharmacology.

[20]  Bingren Hu,et al.  Alterations in Mammalian Target of Rapamycin Signaling Pathways after Traumatic Brain Injury , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[21]  Jian Wang,et al.  Inflammation after Intracerebral Hemorrhage , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  E. Shohami,et al.  Rapamycin is a neuroprotective treatment for traumatic brain injury , 2007, Neurobiology of Disease.

[23]  Qing Wang,et al.  The inflammatory response in stroke , 2007, Journal of Neuroimmunology.

[24]  Ravi S. Menon,et al.  Theoretical and Experimental Optimization of Laser Speckle Contrast Imaging for High Specificity to Brain Microcirculation , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[25]  E. Suri‐Payer,et al.  Regulatory T cells in experimental autoimmune disease , 2006, Springer Seminars in Immunopathology.

[26]  C. Rowe,et al.  Inflammation following stroke , 2006, Journal of Clinical Neuroscience.

[27]  R. Keep,et al.  Mechanisms of brain injury after intracerebral haemorrhage , 2006, The Lancet Neurology.

[28]  M. Battaglia,et al.  Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. , 2005, Blood.

[29]  A. O’Garra,et al.  Regulatory T cells and mechanisms of immune system control , 2004, Nature Medicine.

[30]  T. Harris,et al.  TOR Signaling , 2003, Science's STKE.

[31]  K. Inoki,et al.  TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.

[32]  H. Braak,et al.  Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. , 2003, The American journal of pathology.

[33]  T. Inagawa What are the actual incidence and mortality rates of intracerebral hemorrhage? , 2002, Neurosurgical Review.

[34]  E. Hafen,et al.  dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 , 2002, Nature cell biology.

[35]  R. Dantzer,et al.  Interleukin-10 in the brain. , 2001, Critical reviews in immunology.

[36]  O. Meyuhas Synthesis of the translational apparatus is regulated at the translational level. , 2000, European journal of biochemistry.

[37]  R. Schliebs,et al.  Interleukin‐1β, inducible nitric oxide synthase, and nuclear factor‐κB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon‐γ injection , 1999 .

[38]  J. Krupiński,et al.  A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans. , 1997, Stroke.

[39]  W. Deinsberger,et al.  Experimental intracerebral hemorrhage: description of a double injection model in rats. , 1996, Neurological research.

[40]  J. Krupiński,et al.  Increased Expression of TGF-β1 in Brain Tissue After Ischemic Stroke in Humans , 1996 .

[41]  E. Shohami,et al.  Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat , 1995, Brain Research.

[42]  Paul Tempst,et al.  RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.

[43]  Stuart L. Schreiber,et al.  A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.

[44]  J. Kunz,et al.  Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression , 1993, Cell.

[45]  M. Kornfeld,et al.  Collagenase-induced intracerebral hemorrhage in rats. , 1990, Stroke.

[46]  S. Tsirka,et al.  Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage , 2005, Neurocritical care.

[47]  T. Ingall Stroke--incidence, mortality, morbidity and risk. , 2004, Journal of insurance medicine.

[48]  K. Gurevich,et al.  [Effects of interferon-gamma on the central nervous system]. , 2002, Uspekhi fiziologicheskikh nauk.

[49]  R. Schliebs,et al.  Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection. , 1999, Journal of neuroscience research.

[50]  T. Schallert,et al.  Use-dependent structural events in recovery of function. , 1997, Advances in neurology.

[51]  J. Krupiński,et al.  Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans. , 1996, Stroke.

[52]  D. Ferrari,et al.  Activation of microglial cells by beta-amyloid protein and interferon-gamma. , 1995, Nature.

[53]  Raul G Nogueira,et al.  Spontaneous intracerebral hemorrhage. , 1992, Neurosurgery clinics of North America.