Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release.

[1]  V. Borutaite,et al.  Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia. , 2003, Journal of molecular and cellular cardiology.

[2]  Jorge D. Erusalimsky,et al.  Does nitric oxide modulate mitochondrial energy generation and apoptosis? , 2002, Nature Reviews Molecular Cell Biology.

[3]  E. Clementi,et al.  Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation. , 2001, The Biochemical journal.

[4]  W. Bloch,et al.  Ischemia increases detectable endothelial nitric oxide synthase in rat and human myocardium. , 2001, Nitric oxide : biology and chemistry.

[5]  Tomoki,et al.  N‐methyl‐D‐aspartate receptor‐mediated mitochondrial Ca2+ overload in acute excitotoxic motor neuron death: A mechanism distinct from chronic neurotoxicity after Ca2+ influx , 2001 .

[6]  G. Brown,et al.  Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols. , 2000, Biochimica et biophysica acta.

[7]  S. Larner,et al.  p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons , 2000, The Journal of cell biology.

[8]  M. Duchen,et al.  Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons , 1999, The Journal of physiology.

[9]  M. Moskowitz,et al.  Pathobiology of ischaemic stroke: an integrated view , 1999, Trends in Neurosciences.

[10]  P. Nicotera,et al.  Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis. , 1999, Experimental cell research.

[11]  L. Boscá,et al.  Mechanisms of nitric oxide-dependent apoptosis: involvement of mitochondrial mediators. , 1999, Cellular signalling.

[12]  H. Terada,et al.  Effect of endogenous nitric oxide on energy metabolism of rat heart mitochondria during ischemia and reperfusion. , 1999, Free radical biology & medicine.

[13]  G. Brown,et al.  Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca(2+)-induced inhibition of substrate oxidation. , 1999, Biochimica et biophysica acta.

[14]  R. Radi,et al.  Glyceraldehyde-3-phosphate dehydrogenase inactivation by peroxynitrite. , 1998, Archives of biochemistry and biophysics.

[15]  Ian J. Reynolds,et al.  Glutamate-induced neuron death requires mitochondrial calcium uptake , 1998, Nature Neuroscience.

[16]  M. Beal,et al.  Excitotoxicity and nitric oxide in parkinson's disease pathogenesis , 1998, Annals of neurology.

[17]  E. Clementi,et al.  Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[18]  A. Halestrap,et al.  Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury , 1997 .

[19]  G. Kroemer,et al.  Nitric oxide induces apoptosis via triggering mitochondrial permeability transition , 1997, FEBS letters.

[20]  A. Saraste,et al.  Apoptosis in human acute myocardial infarction. , 1997, Circulation.

[21]  B. Brüne,et al.  Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways. , 1996, The Biochemical journal.

[22]  M. Murphy,et al.  Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite , 1996, Biochemistry and molecular biology international.

[23]  G. Brown,et al.  Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischemia. , 1996, Journal of molecular and cellular cardiology.

[24]  R. Radi,et al.  Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. , 1996, Archives of biochemistry and biophysics.

[25]  J. Poderoso,et al.  Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. , 1996, Archives of biochemistry and biophysics.

[26]  A. Vercesi,et al.  Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial‐generated reactive oxygen species , 1996, FEBS letters.

[27]  M. Murphy,et al.  Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A , 1994, FEBS letters.

[28]  S. Moncada,et al.  Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide , 1994, FEBS letters.

[29]  S Moncada,et al.  Nitric oxide synthases in mammals. , 1994, The Biochemical journal.

[30]  M. Crompton,et al.  On the involvement of a mitochondrial pore in reperfusion injury , 1993, Basic Research in Cardiology.

[31]  J. Mccormack,et al.  Changes in mitochondrial matrix free calcium in perfused rat hearts subjected to hypoxia-reoxygenation. , 1993, Journal of molecular and cellular cardiology.

[32]  M. Chopp,et al.  Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  M. Zoratti,et al.  Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. , 1992, The Journal of biological chemistry.

[34]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[35]  P. Spieckermann,et al.  Development of ischemia-induced damage in defined mitochondrial subpopulations. , 1985, Journal of molecular and cellular cardiology.

[36]  R. Mason,et al.  Ca2+ and Mg2+-enhanced reduction of arsenazo III to its anion free radical metabolite and generation of superoxide anion by an outer mitochondrial membrane azoreductase. , 1984, The Journal of biological chemistry.

[37]  William Rouslin.  Mitochondrial complexes I, II, III, IV, and V in myocardial ischemia and autolysis. , 1983, The American journal of physiology.

[38]  T. Ozawa,et al.  Reversal of ischemia-induced mitochondrial dysfunction after coronary reperfusion , 1982 .

[39]  A. Schapira,et al.  Causes of neuronal death in Parkinson's disease. , 2001, Advances in neurology.

[40]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. , 2000, Journal of neural transmission. Supplementum.

[41]  E. Cadenas,et al.  Nitric oxide regulates oxygen uptake and hydrogen peroxide release by the isolated beating rat heart. , 1998, American journal of physiology. Cell physiology.

[42]  S. Padmaja,et al.  The reaction of no with superoxide. , 1993, Free radical research communications.

[43]  D. Acosta,et al.  Mitochondrial regulation of superoxide by Ca2+: an alternate mechanism for the cardiotoxicity of doxorubicin. , 1991, Toxicology and applied pharmacology.

[44]  A. Fabiato,et al.  Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. , 1979, Journal de physiologie.