Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models
暂无分享,去创建一个
[1] E. Zrenner,et al. Three novel rhodopsin mutations (C110F, L131P, A164V) in patients with autosomal dominant retinitis pigmentosa. , 1994, Human molecular genetics.
[2] A. Goede,et al. Loops In Proteins (LIP)--a comprehensive loop database for homology modelling. , 2003, Protein engineering.
[3] J. Parma,et al. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas , 1993, Nature.
[4] R. Paschke,et al. Contacts between Extracellular Loop Two and Transmembrane Helix Six Determine Basal Activity of the Thyroid-stimulating Hormone Receptor* , 2007, Journal of Biological Chemistry.
[5] Patrick Scheerer,et al. Crystal structure of the ligand-free G-protein-coupled receptor opsin , 2008, Nature.
[6] H. Weinstein,et al. Structural mimicry of proline kinks: tertiary packing interactions support local structural distortions. , 2002, Journal of molecular biology.
[7] D. Oprian,et al. Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness , 1994, Nature.
[8] B. Raaka,et al. Understanding the structural and functional differences between mouse thyrotropin‐releasing hormone receptors 1 and 2 , 2008, Proteins.
[9] M. Wheatley,et al. The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices. , 2004, Biochemical Society transactions.
[10] D. Bichet,et al. Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus , 1992, Nature.
[11] Oliver P. Ernst,et al. Crystal structure of opsin in its G-protein-interacting conformation , 2008, Nature.
[12] K. Clément,et al. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. , 2006, The Journal of clinical endocrinology and metabolism.
[13] Stefano Costanzi,et al. On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. , 2008, Journal of medicinal chemistry.
[14] Rodrigo Lopez,et al. Clustal W and Clustal X version 2.0 , 2007, Bioinform..
[15] H. Schiöth,et al. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. , 2003, Molecular pharmacology.
[16] Marie Chabbert,et al. An Indel in Transmembrane Helix 2 Helps to Trace the Molecular Evolution of Class A G-Protein-Coupled Receptors , 2009, Journal of Molecular Evolution.
[17] Andreas Hildebrandt,et al. Revisiting automated G-protein coupled receptor modeling: the benefit of additional template structures for a neurokinin-1 receptor model. , 2009, Journal of medicinal chemistry.
[18] Jan Freudenberg,et al. Cannabinoid receptor type 2 gene is associated with human osteoporosis. , 2005, Human molecular genetics.
[19] M. Burghammer,et al. Crystal structure of the human β2 adrenergic G-protein-coupled receptor , 2007, Nature.
[20] Krzysztof Palczewski,et al. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin , 2006, Proceedings of the National Academy of Sciences.
[21] S. Tunaru,et al. Characterization of Determinants of Ligand Binding to the Nicotinic Acid Receptor GPR109A (HM74A/PUMA-G) , 2005, Molecular Pharmacology.
[22] Raymond C Stevens,et al. Discovery of new GPCR biology: one receptor structure at a time. , 2009, Structure.
[23] R. Stevens,et al. The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist , 2008, Science.
[24] J. Stockman. Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease , 2010 .
[25] G. Krause,et al. Molecular and conformational features of a transport-relevant domain in the C-terminal tail of the vasopressin V(2) receptor. , 2000, Molecular pharmacology.
[26] S Henikoff,et al. Performance evaluation of amino acid substitution matrices , 1993, Proteins.
[27] S. A. Hassan,et al. Key issues in the computational simulation of GPCR function: representation of loop domains , 2002, J. Comput. Aided Mol. Des..
[28] A. Hopkins,et al. The druggable genome , 2002, Nature Reviews Drug Discovery.
[29] Gebhard F. X. Schertler,et al. Structure of a β1-adrenergic G-protein-coupled receptor , 2008, Nature.
[30] Manfred Burghammer,et al. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. , 2007, Nature.
[31] R. Stevens,et al. High-Resolution Crystal Structure of an Engineered Human β2-Adrenergic G Protein–Coupled Receptor , 2007, Science.
[32] J. Jan,et al. Acquired ocular visual impairment in children. 1960-1989. , 1993, American journal of diseases of children.
[33] H. Guy,et al. Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function* , 1999, The Journal of Biological Chemistry.
[34] R. Koup,et al. Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7. , 2001, Virology.
[35] H Weinstein,et al. Agonists induce conformational changes in transmembrane domains III and VI of the β2 adrenoceptor , 1997, The EMBO journal.
[36] W. Delano. The PyMOL Molecular Graphics System (2002) , 2002 .
[37] Viktor Hornak,et al. Helix Movement is Coupled to Displacement of the Second Extracellular Loop in Rhodopsin Activation , 2009, Nature Structural &Molecular Biology.
[38] D. Clark Robert,et al. Ligand- and Structure-Based Virtual Screening , 2010 .
[39] Krzysztof Palczewski,et al. Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors , 2009, Proceedings of the National Academy of Sciences.
[40] T. Schöneberg,et al. Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with Obesity* , 2003, Journal of Biological Chemistry.
[41] Tsutomu Kouyama,et al. Crystal structure of squid rhodopsin , 2008, Nature.
[42] G. Krause,et al. Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB , 2009, Journal of peptide science : an official publication of the European Peptide Society.
[43] Gert Vriend,et al. GPCRDB information system for G protein-coupled receptors , 2003, Nucleic Acids Res..
[44] H. Schiöth,et al. The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes , 2005, Molecular Pharmacology.
[45] U. Leser,et al. Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource. , 2007, Molecular endocrinology.
[46] S. Filetti,et al. Activating mutations of the TSH receptor in differentiated thyroid carcinomas. , 1995, Oncogene.
[47] B. Dean,et al. Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia , 2002, Molecular Psychiatry.
[48] T. N. Bhat,et al. The Protein Data Bank , 2000, Nucleic Acids Res..
[49] Gert Vriend,et al. GRIS: glycoprotein-hormone receptor information system. , 2006, Molecular endocrinology.
[50] Gerhard Hessler,et al. Drug Design Strategies for Targeting G‐Protein‐Coupled Receptors , 2002, Chembiochem : a European journal of chemical biology.
[51] J. Ballesteros,et al. [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors , 1995 .
[52] G Vriend,et al. Heavier‐than‐air flying machines are impossible , 2004, FEBS letters.
[53] Charles L. Brooks,et al. Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008 , 2009, Nature Reviews Drug Discovery.
[54] K. Clément,et al. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. , 2000, The Journal of clinical investigation.
[55] Katrin Sangkuhl,et al. Mutant G-protein-coupled receptors as a cause of human diseases. , 2004, Pharmacology & therapeutics.
[56] R. Seyer,et al. Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR. , 2009, Journal of molecular biology.
[57] K. Palczewski,et al. Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor , 2000, Science.
[58] R. Paschke,et al. Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor – a basally active GPCR , 2008, Cellular and Molecular Life Sciences.
[59] D. Oprian,et al. Constitutively active mutants of rhodopsin , 1992, Neuron.
[60] Duan Yang,et al. The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[61] M. Schott. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice , 2010 .
[62] E. Jönsson,et al. The Cys allele of the DRD2 Ser311Cys polymorphism has a dominant effect on risk for schizophrenia: Evidence from fixed‐ and random‐effects meta‐analyses , 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[63] Manfred Burghammer,et al. Crystal structure of a thermally stable rhodopsin mutant. , 2007, Journal of molecular biology.
[64] David Julius,et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs , 2001, Nature.
[65] R. Adan,et al. Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with Obesity* , 2003, Journal of Biological Chemistry.
[66] A. Meyer-Lindenberg,et al. Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans , 2009, Molecular Psychiatry.
[67] S. Rasmussen,et al. The structure and function of G-protein-coupled receptors , 2009, Nature.
[68] Q. Gu,et al. Activating Smoothened mutations in sporadic basal-cell carcinoma , 1998, Nature.
[69] Ron O Dror,et al. Identification of two distinct inactive conformations of the β2-adrenergic receptor reconciles structural and biochemical observations , 2009, Proceedings of the National Academy of Sciences.
[70] Baldomero Oliva,et al. A supersecondary structure library and search algorithm for modeling loops in protein structures , 2006, Nucleic acids research.
[71] J. Hebebrand,et al. A Heterozygous Mutation in the Third Transmembrane Domain Causes a Dominant-Negative Effect on Signalling Capability of the MC4R , 2008, Obesity Facts.
[72] D. Tregouet,et al. Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. , 2007, The Journal of clinical endocrinology and metabolism.
[73] Tetsuya Hori,et al. Crystal Structure of Squid Rhodopsin with Intracellularly Extended Cytoplasmic Region , 2008, Journal of Biological Chemistry.
[74] K. Palczewski,et al. Activation of rhodopsin: new insights from structural and biochemical studies. , 2001, Trends in biochemical sciences.
[75] W. Delano. The PyMOL Molecular Graphics System , 2002 .
[76] William C. Olson,et al. Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry , 1998, Journal of Virology.
[77] R. Seifert,et al. Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins. , 2000, Molecular pharmacology.
[78] A. D. McLachlan,et al. Rapid comparison of protein structures , 1982 .
[79] Cathy H. Wu,et al. The Universal Protein Resource (UniProt) , 2004, Nucleic Acids Res..
[80] D. Doyle,et al. Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. , 1999, The New England journal of medicine.
[82] Nagarajan Vaidehi,et al. Agonist-induced conformational changes in bovine rhodopsin: insight into activation of G-protein-coupled receptors. , 2008, Journal of molecular biology.
[83] N. Samani,et al. Dimorphism in the P2Y1 ADP Receptor Gene Is Associated With Increased Platelet Activation Response to ADP , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[84] Charlotte M. Deane,et al. JOY: protein sequence-structure representation and analysis , 1998, Bioinform..
[85] H. Attrill,et al. Improved yield of a ligand-binding GPCR expressed in E. coli for structural studies. , 2009, Protein expression and purification.
[86] Shuguang Zhang,et al. High-Level Production, Solubilization and Purification of Synthetic Human GPCR Chemokine Receptors CCR5, CCR3, CXCR4 and CX3CR1 , 2009, PloS one.
[87] R. Pierson,et al. Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor. , 2003, The New England journal of medicine.