Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folat
暂无分享,去创建一个
Wei Zhu | D. Priest | M. Bunni | P. Melera | Z. Chen | J. L. DiCapua | J. M. Dressler | J. M. Dressler
[1] Wei Zhu,et al. BASAL LEVELS OF METALLOTHIONEIN I AND II EXPRESSION IN MOUSE EMBRYO FIBROBLASTS ENHANCE GROWTH IN LOW FOLATE THROUGH A CELL CYCLE MEDIATED PATHWAY , 2001, Cell biology international.
[2] T. Liu,et al. Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells. , 2001, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[3] G. Peters,et al. Folate depletion increases sensitivity of solid tumor cell lines to 5‐fluorouracil and antifolates , 2000, International journal of cancer.
[4] G. Peters,et al. Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors. , 2000, Annals of oncology : official journal of the European Society for Medical Oncology.
[5] P. Caspers,et al. Cyclophilin-promoted folding of mouse dihydrofolate reductase does not include the slow conversion of the late-folding intermediate to the active enzyme. , 2000, Journal of molecular biology.
[6] M. Mouat. Dihydrofolate influences the activity of Escherichia coli dihydrofolate reductase synthesised de novo. , 2000, The international journal of biochemistry & cell biology.
[7] P. Melera,et al. Metallothionein is overexpressed by hamster fibroblasts selected for growth in 15 pm folinic acid and provides a growth advantage in low folate. , 1999, Cancer research.
[8] G. Peters,et al. Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration. , 1999, Molecular pharmacology.
[9] G. Maley,et al. Thymidylate Synthase Protein and p53 mRNA Form an In Vivo Ribonucleoprotein Complex , 1999, Molecular and Cellular Biology.
[10] A. Kinsella,et al. Tumor resistance to antimetabolites. , 1998, General pharmacology.
[11] M. Waltham,et al. Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region. , 1997, Biochemistry.
[12] B. Ames,et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[13] J. C. Schmitz,et al. Disposition of leucovorin and its metabolites in dietary folic acid-deplete mice – comparison between tumor, liver and plasma , 1997, Cancer Chemotherapy and Pharmacology.
[14] I. Pogribny,et al. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. , 1997, The American journal of clinical nutrition.
[15] J. Schornagel,et al. Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate , 1996, Cancer Chemotherapy and Pharmacology.
[16] M. Spinella,et al. Characterization of a Mutation in the Reduced Folate Carrier in a Transport Defective L1210 Murine Leukemia Cell Line (*) , 1995, The Journal of Biological Chemistry.
[17] J. Lazo,et al. Metallothionein null cells have increased sensitivity to anticancer drugs. , 1995, Cancer research.
[18] M. Spinella,et al. Distinguishing between Folate Receptor-α-mediated Transport and Reduced Folate Carrier-mediated Transport in L1210 Leukemia Cells (*) , 1995, The Journal of Biological Chemistry.
[19] A. Basnakian,et al. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. , 1994, Cancer research.
[20] J. Lazo,et al. Role of metallothionein in carcinogenesis. , 1994, Toxicology and applied pharmacology.
[21] M. Spinella,et al. Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells. , 1994, Biochemical pharmacology.
[22] M. Yu,et al. Allelic variation in the dihydrofolate reductase gene at amino acid position 95 contributes to antifolate resistance in Chinese hamster cells. , 1993, Cancer research.
[23] C. Takimoto,et al. Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro. , 1993, Biochemistry.
[24] P. Elwood,et al. Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates. , 1993, The Journal of clinical investigation.
[25] P. Elwood,et al. Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells. , 1992, The Journal of biological chemistry.
[26] L. Gentry,et al. Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates. , 1992, Biochemical pharmacology.
[27] B. Jonsson,et al. Isomerase and chaperone activity of prolyl isomerase in the folding of carbonic anhydrase. , 1992, Science.
[28] B. Wu,et al. Transfection of a glycosylated phosphatidylinositol-anchored folate-binding protein complementary DNA provides cells with the ability to survive in low folate medium. , 1992, The Journal of clinical investigation.
[29] J. Schornagel,et al. In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate , 1992, International journal of cancer.
[30] R. G. Anderson,et al. Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[31] Y. Miyata,et al. The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity. , 1992, The Journal of biological chemistry.
[32] J. Schornagel,et al. Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems. , 1991, Cancer research.
[33] P C Elwood,et al. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[34] R. Seither,et al. Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate. , 1991, Biochemical pharmacology.
[35] J. Schornagel,et al. Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates. , 1990, The Journal of biological chemistry.
[36] M J Schlesinger,et al. Heat shock proteins. , 1990, The Journal of biological chemistry.
[37] S. Muench,et al. Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells. , 1990, Biochemical pharmacology.
[38] D C Mikulecky,et al. Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells. , 1989, The Journal of biological chemistry.
[39] P F Morrison,et al. Folate cycle kinetics in human breast cancer cells. , 1989, The Journal of biological chemistry.
[40] J. Schornagel,et al. Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance. , 1989, Cancer research.
[41] J. Schornagel,et al. Expression of a folate binding protein in L1210 cells grown in low folate medium. , 1989, Cancer research.
[42] D. Hamer,et al. Overexpression of metallothionein confers resistance to anticancer drugs. , 1988, Science.
[43] D. Priest,et al. Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells. , 1988, Cancer research.
[44] L. Matherly,et al. The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue. , 1987, The Journal of biological chemistry.
[45] D. Priest,et al. Tissue folate polyglutamate chain length determination by electrophoresis as thymidylate synthase-fluorodeoxyuridylate ternary complexes. , 1986, Methods in enzymology.
[46] C. Allegra,et al. Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[47] K. Scotto,et al. Antifolate-resistant Chinese Hamster Cells. mRNA directed overproduction of multiple dihydrofolate reductases from a series of independently derived sublines containing amplified dihydrofolate reductase genes. , 1982, The Journal of biological chemistry.
[48] J. Davide,et al. Selective amplification of polymorphic dihydrofolate reductase gene loci in Chinese hamster lung cells. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[49] M. M. Bradford. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.
[50] D. Santi,et al. A filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant. , 1974, Biochemistry.
[51] J. Bertino,et al. The turnover of folate coenzymes in murine lymphoma cells. , 1973, The Journal of biological chemistry.
[52] D. Hutchison,et al. Two different species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin. , 1972, Cancer research.
[53] I. Djerassi,et al. Long-Term Remissions in Childhood Acute Leukemia , 1966 .