Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels.
暂无分享,去创建一个
Yoshiyuki Yamada | M. Rothenberg | A. Filipovich | J. Villanueva | A. Assa’ad | M. Stein | Bridget K. Buckmeier | A. Assa'ad | B. K. Buckmeier
[1] J. Parkin,et al. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. , 2008, The New England journal of medicine.
[2] S. Phipps,et al. Eosinophil trafficking in allergy and asthma. , 2007, The Journal of allergy and clinical immunology.
[3] M. Collins,et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. , 2006, The Journal of allergy and clinical immunology.
[4] James J. Lee,et al. Schistosoma mansoni infection in eosinophil lineage-ablated mice. , 2006, Blood.
[5] H. Simon,et al. Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report. , 2006, The Journal of allergy and clinical immunology.
[6] T. Haverty,et al. Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti-IL-5 antibody SCH55700. , 2004, The Journal of allergy and clinical immunology.
[7] T. Haverty,et al. Safety and efficacy of the monoclonal anti-interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome. , 2004, Blood.
[8] M. Rothenberg. Eosinophilic gastrointestinal disorders (EGID). , 2004, The Journal of allergy and clinical immunology.
[9] J. Boyce,et al. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. , 2004, The Journal of allergy and clinical immunology.
[10] J. Ring,et al. Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis. , 2003, The New England journal of medicine.
[11] S. Phipps,et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. , 2003, The Journal of clinical investigation.
[12] D. Postma,et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. , 2003, American journal of respiratory and critical care medicine.
[13] Peter Marynen,et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. , 2003, The New England journal of medicine.
[14] A. Kay,et al. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. , 2003, American journal of respiratory and critical care medicine.
[15] M. Rothenberg,et al. Receptor internalization is required for eotaxin-induced responses in human eosinophils. , 2003, The Journal of allergy and clinical immunology.
[16] M. Rothenberg,et al. IL-5 Promotes Eosinophil Trafficking to the Esophagus1 , 2002, The Journal of Immunology.
[17] D. Marmer,et al. Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members. , 2002, Blood.
[18] A. Straumann,et al. Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. , 2001, The Journal of allergy and clinical immunology.
[19] M. Rothenberg,et al. An etiological role for aeroallergens and eosinophils in experimental esophagitis. , 2001, The Journal of clinical investigation.
[20] K. Chung,et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response , 2000, The Lancet.
[21] K. Willard-Gallo,et al. Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome , 2000, British journal of haematology.
[22] J. Vandekerckhove,et al. Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit. , 2000, Blood.
[23] C. Davis,et al. Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. , 1999, The Journal of pharmacology and experimental therapeutics.
[24] S. Bel,et al. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. , 1999, Journal of immunology.
[25] R. Dummer,et al. Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia. , 1999, The New England journal of medicine.
[26] P. Foster,et al. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model , 1996, The Journal of experimental medicine.
[27] F. Finkelman,et al. Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. , 1993, Journal of immunology.
[28] D. Jones. The eosinophil. , 1993, Journal of comparative pathology.
[29] B. Andresen,et al. Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cells. , 1992, Experimental cell research.
[30] C. Sanderson,et al. Interleukin-5, eosinophils, and disease. , 1992, Blood.
[31] M. Tsujimoto,et al. Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells. , 1990, Journal of biochemistry.
[32] R. Coffman,et al. In vivo administration of antibody to interleukin-5 inhibits increased generation of eosinophils and their progenitors in bone marrow of parasitized mice. , 1990, Blood.
[33] M. Samoszuk,et al. Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia. , 1990, Blood.
[34] A. Sheffer,et al. Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome , 1989, The Journal of experimental medicine.
[35] W. Solbach. Brief Definitive Report TUMOR-PROMOTING PHORBOL ESTERS SELECTIVELY ABROGATE THE EXPRESSION OF THE T4 DIFFERENTIATION ANTIGEN EXPRESSED ON NORMAL AND MALIGNANT (SI),ZARY) T HELPER LYMPHOCYTES* , 2003 .