The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses

[1]  Eric R. Kandel,et al.  Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin , 2001, Cell.

[2]  E. Kandel,et al.  Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2 , 2000, Cell.

[3]  R U Muller,et al.  Parallel Instabilities of Long-Term Potentiation, Place Cells, and Learning Caused by Decreased Protein Kinase A Activity , 2000, The Journal of Neuroscience.

[4]  Eric R Kandel,et al.  Local protein synthesis and its role in synapse-specific plasticity , 2000, Current Opinion in Neurobiology.

[5]  E. Kandel,et al.  A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis , 1999, Cell.

[6]  F. Engert,et al.  Dendritic spine changes associated with hippocampal long-term synaptic plasticity , 1999, Nature.

[7]  Samuel Schacher,et al.  Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia , 1999, Neuron.

[8]  Eric R Kandel,et al.  CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation , 1998, Cell.

[9]  Scott T. Wong,et al.  Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation , 1998, Neuron.

[10]  C Kentros,et al.  Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade. , 1998, Science.

[11]  S. Shenolikar,et al.  Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. , 1998, Science.

[12]  E. Kandel,et al.  Cognitive Neuroscience and the Study of Memory , 1998, Neuron.

[13]  Eric R Kandel,et al.  Restricted and Regulated Overexpression Reveals Calcineurin as a Key Component in the Transition from Short-Term to Long-Term Memory , 1998, Cell.

[14]  E. Kandel,et al.  Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin , 1998, Cell.

[15]  E. Kandel,et al.  Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage , 1997, Cell.

[16]  R. Nicoll,et al.  Silent Synapses Speak Up , 1997, Neuron.

[17]  Eric R. Kandel,et al.  Recruitment of New Sites of Synaptic Transmission During the cAMP-Dependent Late Phase of LTP at CA3–CA1 Synapses in the Hippocampus , 1997, Neuron.

[18]  Eric R Kandel,et al.  MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia , 1997, Neuron.

[19]  E. Kandel,et al.  Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons , 1997, Neuron.

[20]  James H. Schwartz,et al.  Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia , 1997, Cell.

[21]  E. Kandel,et al.  Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory , 1997, Cell.

[22]  E. Schuman,et al.  Synapse Specificity and Long-Term Information Storage , 1997, Neuron.

[23]  U. Frey,et al.  Synaptic tagging and long-term potentiation , 1997, Nature.

[24]  O. Steward,et al.  mRNA Localization in Neurons: A Multipurpose Mechanism? , 1997, Neuron.

[25]  E. Kandel,et al.  Mice Expressing Activated CaMKII Lack Low Frequency LTP and Do Not Form Stable Place Cells in the CA1 Region of the Hippocampus , 1996, Cell.

[26]  K. I. Blum,et al.  Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice , 1996, Cell.

[27]  R. Muller,et al.  A Quarter of a Century of Place Cells , 1996, Neuron.

[28]  J. David Sweatt,et al.  Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation* , 1996, The Journal of Biological Chemistry.

[29]  E R Kandel,et al.  Presynaptic facilitation revisited: state and time dependence , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[30]  Mary Chen,et al.  Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change , 1995, Cell.

[31]  S. Siegelbaum,et al.  Regulation of hippocampal transmitter release during development and long-term potentiation. , 1995, Science.

[32]  E. Kandel,et al.  D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[33]  C. Stevens,et al.  Changes in reliability of synaptic function as a mechanism for plasticity , 1994, Nature.

[34]  Alcino J. Silva,et al.  Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein , 1994, Cell.

[35]  E. Kandel,et al.  Requirement of a critical period of transcription for induction of a late phase of LTP. , 1994, Science.

[36]  E. Kandel,et al.  Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization. , 1994, Learning & memory.

[37]  E. Kandel,et al.  C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia , 1994, Cell.

[38]  N Dale,et al.  L-glutamate may be the fast excitatory transmitter of Aplysia sensory neurons. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[39]  E. Kandel,et al.  Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. , 1993, Science.

[40]  E R Kandel,et al.  Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. , 1993, Science.

[41]  E. Kandel,et al.  Activation of cAMP-Responsive genes by stimuli that produce long-term facilitation in aplysia sensory neurons , 1993, Neuron.

[42]  E. Kandel,et al.  Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. , 1992, Science.

[43]  E. Kandel,et al.  Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia , 1992, Neuron.

[44]  E. Kandel,et al.  Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. , 1992, Science.

[45]  E R Kandel,et al.  Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia. , 1992, Science.

[46]  L. Squire,et al.  The medial temporal lobe memory system , 1991, Science.

[47]  H. S. Kim,et al.  Cotransformation and gene targeting in mouse embryonic stem cells , 1991, Molecular and cellular biology.

[48]  E. Kandel,et al.  Target-dependent structural changes accompanying long-term synaptic facilitation in Aplysia neurons. , 1990, Science.

[49]  Eric R. Kandel,et al.  Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation , 1990, Nature.

[50]  E R Kandel,et al.  Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[51]  R. Hawkins,et al.  Identified serotonergic neurons LCB1 and RCB1 in the cerebral ganglia of Aplysia produce presynaptic facilitation of siphon sensory neurons , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[52]  B. Koller,et al.  Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[53]  C. H. Bailey,et al.  Time course of structural changes at identified sensory neuron synapses during long-term sensitization in Aplysia , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[54]  Mario R. Capecchi,et al.  Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes , 1988, Nature.

[55]  E. Kandel,et al.  cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis. , 1988, Science.

[56]  C. H. Bailey,et al.  Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[57]  E R Kandel,et al.  A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. , 1986, Science.

[58]  E. Kandel,et al.  Facilitatory transmitters and cAMP can modulate accommodation as well as transmitter release in Aplysia sensory neurons: Evidence for parallel processing in a single cell. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[59]  S. Schacher,et al.  Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[60]  W N Frost,et al.  Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplysia participate in the storage of long-term memory for sensitization. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[61]  E. Kandel,et al.  A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation. , 1983, Science.

[62]  E. Kandel,et al.  Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica. , 1983, Science.

[63]  E. Kandel,et al.  Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[64]  E. Kandel,et al.  Molecular biology of learning: modulation of transmitter release. , 1982, Science.

[65]  E. Kandel,et al.  Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones , 1982, Nature.

[66]  E. Kandel,et al.  Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. II. Identified neurons produce heterosynaptic facilitation contributing to behavioral sensitization. , 1981, Journal of neurophysiology.

[67]  E R Kandel,et al.  Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. I. Identification and characterization. , 1981, Journal of neurophysiology.

[68]  E. Kandel,et al.  Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[69]  E. Kandel,et al.  Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[70]  V. Castellucci,et al.  Sensitization in Aplysia: restoration of transmission in synapses inactivated by long-term habituation. , 1979, Science.

[71]  E R Kandel,et al.  Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica. , 1978, Science.

[72]  L. Nadel,et al.  The Hippocampus as a Cognitive Map , 1978 .

[73]  E. Kandel,et al.  Stimulus-response relations and stability of mechanoreceptor and motor neurons mediating defensive gill-withdrawal reflex in Aplysia. , 1978, Journal of neurophysiology.

[74]  E. Kandel,et al.  Contribution of individual mechanoreceptor sensory neurons to defensive gill-withdrawal reflex in Aplysia. , 1978, Journal of neurophysiology.

[75]  E. Kandel,et al.  Presynaptic facilitation as a mechanism for behavioral sensitization in Aplysia. , 1976, Science.

[76]  E R Kandel,et al.  Synaptic facilitation and behavioral sensitization in Aplysia: possible role of serotonin and cyclic AMP. , 1976, Science.

[77]  P. Greengard.  Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters† , 1976, Nature.

[78]  E. Kandel,et al.  A quantal analysis of the synaptic depression underlying habituation of the gill-withdrawal reflex in Aplysia. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[79]  E. Kandel,et al.  Receptive fields and response properties of mechanoreceptor neurons innervating siphon skin and mantle shelf in Aplysia. , 1974, Journal of neurophysiology.

[80]  E. Kandel,et al.  Metamorphosis of Aplysia californica in laboratory culture. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[81]  T. Bliss,et al.  Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path , 1973, The Journal of physiology.

[82]  E. Kandel,et al.  Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica , 1972, The Journal of general physiology.

[83]  J. H. Schwartz,et al.  Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica , 1972, The Journal of general physiology.

[84]  Eric R. Kandel,et al.  Long-Term Habituation of a Defensive Withdrawal Reflex in Aplysia , 1972, Science.

[85]  E R Kandel,et al.  Functioning of identified neurons and synapses in abdominal ganglion of Aplysia in absence of protein synthesis. , 1971, Journal of neurophysiology.

[86]  Irving Kupfermann,et al.  Neuronal Correlates of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia , 1970, Science.

[87]  E. Kandel,et al.  Habituation and Dishabituation of the GM-Withdrawal Reflex in Aplysia , 1970, Science.

[88]  E R Kandel,et al.  Neuronal Controls of a Behavioral Response Mediated by the Abdominal Ganglion of Aplysia , 1969, Science.

[89]  E. Kandel,et al.  MORPHOLOGICAL AND FUNCTIONAL PROPERTIES OF IDENTIFIED NEURONS IN THE ABDOMINAL GANGLION OF APLYSIA CALIFORNICA , 1967 .

[90]  B. Agranoff,et al.  EFFECTS OF PUROMYCIN, ACETOXYCYCLOHEXIMIDE AND ACTINOMYCIN D ON PROTEIN SYNTHESIS IN GOLDFISH BRAIN * , 1966, Journal of neurochemistry.

[91]  L. B. Flexner,et al.  Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[92]  E. Kandel,et al.  ELECTROPHYSIOLOGICAL PROPERTIES OF AN ARCHICORTICAL NEURON , 1961, Annals of the New York Academy of Sciences.

[93]  B. Katz,et al.  An analysis of the end‐plate potential recorded with an intra‐cellular electrode , 1951, The Journal of physiology.

[94]  E. Kandel,et al.  Cyclic AMP induces functional presynaptic boutons in hippocampal CA3–CA1 neuronal cultures , 1999, Nature Neuroscience.

[95]  J. Weiner,et al.  Time, Love, Memory: A Great Biologist and His Quest for the Origins of Behavior , 1999 .

[96]  J. Dubnau,et al.  Gene discovery in Drosophila: new insights for learning and memory. , 1998, Annual review of neuroscience.

[97]  D. Muller.  Ultrastructural Plasticity of Excitatory Synapses , 1997, Reviews in the neurosciences.

[98]  E. Kandel,et al.  Structural changes accompanying memory storage. , 1993, Annual review of physiology.

[99]  E R Kandel,et al.  Inhibitor of protein synthesis blocks long-term behavioral sensitization in the isolated gill-withdrawal reflex of Aplysia. , 1989, Journal of neurobiology.

[100]  G. Lynch,et al.  Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5 , 1986, Nature.

[101]  E. R. Kandel,et al.  Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+channels of Aplysia sensory neurones in cell-free membrane patches , 1985, Nature.

[102]  E. Kandel.  Behavioral biology of Aplysia : a contribution to the comparative study of opisthobranch molluscs , 1979 .

[103]  Eric R. Kandel,et al.  A cell-biological approach to learning , 1978 .

[104]  E R Kandel,et al.  A common presynaptic locus for the synaptic changes underlying short-term habituation and sensitization of the gill-withdrawal reflex in Aplysia. , 1976, Cold Spring Harbor symposia on quantitative biology.

[105]  E. Kandel.  Cellular basis of behavior: An introduction to behavioral neurobiology. , 1976 .

[106]  E. Kandel,et al.  Cellular neurophysiological approaches in the study of learning. , 1968, Physiological reviews.

[107]  S. Ramón y Cajal,et al.  The Croonian lecture.—La fine structure des centres nerveux , 1894, Proceedings of the Royal Society of London.