Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

[1]  G. Scheper,et al.  Translation matters: protein synthesis defects in inherited disease , 2007, Nature Reviews Genetics.

[2]  Mayumi Ito,et al.  Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding , 2007, Nature.

[3]  G. Beaudoin,et al.  Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation , 2006, Cell cycle.

[4]  G. Cotsarelis Epithelial stem cells: a folliculocentric view. , 2006, The Journal of investigative dermatology.

[5]  M. Sachs,et al.  Downstream control of upstream open reading frames. , 2006, Genes & development.

[6]  G. Beaudoin,et al.  Hairless triggers reactivation of hair growth by promoting Wnt signaling. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Liangdan Sun,et al.  Identification of a novel locus for Marie Unna hereditary hypotrichosis to a 17.5 cM interval at 1p21.1-1q21.3. , 2005, The Journal of investigative dermatology.

[8]  Igor B. Rogozin,et al.  Evolutionary conservation suggests a regulatory function of AUG triplets in 5′-UTRs of eukaryotic genes , 2005, Nucleic acids research.

[9]  Graziano Pesole,et al.  uAUG and uORFs in human and rodent 5'untranslated mRNAs. , 2005, Gene.

[10]  Refinement of a locus for Marie Unna hereditary hypotrichosis to a 1·1‐cM interval at 8p21.3 , 2004, The British journal of dermatology.

[11]  Lin Chang-min,et al.  Beta-catenin controls hair follicle morphogenesis and stem cell differentiation , 2004 .

[12]  E. Fearon,et al.  Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. , 2003, Genes & development.

[13]  E. Fuchs,et al.  Stem cells in the skin: waste not, Wnt not. , 2003, Genes & development.

[14]  S. Millar,et al.  WNT signals are required for the initiation of hair follicle development. , 2002, Developmental cell.

[15]  G. Beaudoin,et al.  The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. , 2001, Genes & development.

[16]  R. Happle,et al.  Guess what! Hypotrichosis congenita of Marie Unna: comment. , 2001, European journal of dermatology : EJD.

[17]  W. Birchmeier,et al.  β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin , 2001, Cell.

[18]  A. Christiano,et al.  Patterns of hairless (hr) gene expression in mouse hair follicle morphogenesis and cycling. , 2000, The American journal of pathology.

[19]  S. Cichon,et al.  A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family , 2000, The British journal of dermatology.

[20]  M. Cazzola,et al.  Translational pathophysiology: a novel molecular mechanism of human disease. , 2000, Blood.

[21]  C. Bodemer,et al.  Linkage of Marie-Unna hypotrichosis locus to chromosome 8p21 and exclusion of 10 genes including the hairless gene by mutation analysis , 2000, European Journal of Human Genetics.

[22]  G. Sreekumar,et al.  Marie Unna hereditary hypotrichosis gene maps to human chromosome 8p21 near hairless. , 2000, The Journal of investigative dermatology.

[23]  R Paus,et al.  The biology of hair follicles. , 1999, The New England journal of medicine.

[24]  R. Paus,et al.  What controls hair follicle cycling? , 1999, Experimental dermatology.

[25]  H. Kremer,et al.  The gene for hypotrichosis of Marie Unna maps between D8S258 and D8S298: exclusion of the hr gene by cDNA and genomic sequencing. , 1999, American journal of human genetics.

[26]  R. Bergman,et al.  Identification of a genetic defect in the hairless gene in atrichia with papular lesions: evidence for phenotypic heterogeneity among inherited atrichias. , 1999, American journal of human genetics.

[27]  David Hogg,et al.  Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma , 1999, Nature Genetics.

[28]  S. Cichon,et al.  Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia. , 1998, Human molecular genetics.

[29]  J. Ott,et al.  Alopecia universalis associated with a mutation in the human hairless gene. , 1998, Science.

[30]  R. Skoda,et al.  An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia , 1998, Nature Genetics.