Pharmacological Notch pathway inhibition leads to cell cycle arrest and stimulates ascl1 and neurogenin2 genes expression in dental pulp stem cells-derived neurospheres

[1]  C. Schuurmans,et al.  bHLH transcription factors in neural development, disease, and reprogramming , 2019, Brain Research.

[2]  S. Arias-Santiago,et al.  Epithelial In vitro Differentiation of Mesenchymal Stem Cells. , 2018, Current stem cell research & therapy.

[3]  J. Mapelli,et al.  Use of a 3D Floating Sphere Culture System to Maintain the Neural Crest-Related Properties of Human Dental Pulp Stem Cells , 2018, Front. Physiol..

[4]  B. Lee,et al.  Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair , 2018, Stem cells international.

[5]  P. Hollands,et al.  Dental pulp stem cells in regenerative medicine , 2018, BDJ.

[6]  F. Farassati,et al.  Combination treatment of all-trans retinoic acid (ATRA) and γ-secretase inhibitor (DAPT) cause growth inhibition and apoptosis induction in the human gastric cancer cell line , 2018, Cytotechnology.

[7]  I. Mortada,et al.  Dental pulp stem cells and the management of neurological diseases: An update , 2018, Journal of neuroscience research.

[8]  Gary D Bader,et al.  ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. , 2017, Cell stem cell.

[9]  M. Gholami,et al.  Epi/perineural and Schwann Cells as Well as Perineural Sheath Integrity are Affected Following 2,4-D Exposure , 2017, Neurotoxicity Research.

[10]  B. A. Rodas-Junco,et al.  Dental Pulp Stem Cells: Current Advances in Isolation, Expansion and Preservation , 2017, Tissue Engineering and Regenerative Medicine.

[11]  L. Reiter,et al.  Culturing and Neuronal Differentiation of Human Dental Pulp Stem Cells , 2017, Current Protocols in Human Genetics.

[12]  V. Taylor,et al.  Notch: an interactive player in neurogenesis and disease , 2017, Cell and Tissue Research.

[13]  H. Hamdi-Rozé,et al.  Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain , 2016, Neural Development.

[14]  K. Plath,et al.  Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. , 2016, Cell stem cell.

[15]  S. Bray Notch signalling in context , 2016, Nature Reviews Molecular Cell Biology.

[16]  N. Stocchetti,et al.  Chronic impact of traumatic brain injury on outcome and quality of life: a narrative review , 2016, Critical Care.

[17]  F. Gage,et al.  Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation , 2016, eLife.

[18]  H. Azari,et al.  In Vitro Models for Neurogenesis. , 2016, Cold Spring Harbor perspectives in biology.

[19]  U. Lendahl,et al.  Notch -- a goldilocks signaling pathway in disease and cancer therapy. , 2016, Discovery medicine.

[20]  M. Shao,et al.  Glycometabolic reprogramming associated with the initiation of human dental pulp stem cell differentiation , 2016, Cell biology international.

[21]  HengBoon Chin,et al.  An Overview of Protocols for the Neural Induction of Dental and Oral Stem Cells In Vitro , 2016 .

[22]  T. Nagamura-Inoue,et al.  Neurosphere formation enhances the neurogenic differentiation potential and migratory ability of umbilical cord-mesenchymal stromal cells. , 2016, Cytotherapy.

[23]  H. Salehi,et al.  An Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells , 2015, Stem Cell Reviews and Reports.

[24]  A. Niapour,et al.  Isolation and identification of mesenchymal and neural crest characteristics of dental pulp derived stem cells , 2015 .

[25]  S. Kuang,et al.  Notch signaling as a novel regulator of metabolism , 2015, Trends in Endocrinology & Metabolism.

[26]  A. Rosemann Stem cell treatments for neurodegenerative diseases: challenges from a science, business and healthcare perspective. , 2015, Neurodegenerative disease management.

[27]  E. Feldman,et al.  Notch Signaling Regulates Motor Neuron Differentiation of Human Embryonic Stem Cells , 2015, Stem cells.

[28]  P. Gervois,et al.  Neurogenic maturation of human dental pulp stem cells following neurosphere generation induces morphological and electrophysiological characteristics of functional neurons. , 2015, Stem cells and development.

[29]  S. Razavi,et al.  Effect of T3 hormone on neural differentiation of human adipose derived stem cells , 2014, Cell biochemistry and function.

[30]  Qi-hua He,et al.  Timely Inhibition of Notch Signaling by DAPT Promotes Cardiac Differentiation of Murine Pluripotent Stem Cells , 2014, PloS one.

[31]  H. Clevers,et al.  Glial origin of mesenchymal stem cells in a tooth model system , 2014, Nature.

[32]  R. Barker,et al.  The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro , 2014, Development.

[33]  MußmannCarolin,et al.  HES5 is a key mediator of Wnt-3a-induced neuronal differentiation. , 2014 .

[34]  M. Frech,et al.  HES5 is a key mediator of Wnt-3a-induced neuronal differentiation. , 2014, Stem cells and development.

[35]  R. Barker,et al.  The phosphorylation status of Ascl 1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro , 2014 .

[36]  C. Schuurmans,et al.  Proneural genes in neocortical development , 2013, Neuroscience.

[37]  P. Pavasant,et al.  Notch signaling is involved in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells. , 2013, Stem cells and development.

[38]  K. Alitalo,et al.  Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells , 2013, Cellular and Molecular Life Sciences.

[39]  R. Nishimura,et al.  A comparison of neurosphere differentiation potential of canine bone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells. , 2013, The Journal of veterinary medical science.

[40]  H. Nakauchi,et al.  Stem cell therapy: an exercise in patience and prudence , 2013, Philosophical Transactions of the Royal Society B: Biological Sciences.

[41]  M. Miura,et al.  Neural crest stem cell property of apical pulp cells derived from human developing tooth , 2012, Cell biology international.

[42]  Bengt Fadeel,et al.  MAML1 Acts Cooperatively with EGR1 to Activate EGR1-Regulated Promoters: Implications for Nephrogenesis and the Development of Renal Cancer , 2012, PloS one.

[43]  Hock Chuan Yeo,et al.  Enhanced production of neuroprogenitors, dopaminergic neurons, and identification of target genes by overexpression of sonic hedgehog in human embryonic stem cells. , 2012, Stem cells and development.

[44]  O. Lindvall,et al.  Clinical translation of stem cells in neurodegenerative disorders. , 2012, Cell stem cell.

[45]  T. Qu,et al.  Generation of neural stem cell-like cells from bone marrow-derived human mesenchymal stem cells , 2011, Neurological research.

[46]  F. Guillemot,et al.  Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis , 2011, Development.

[47]  A. Lleó,et al.  γ-secretase substrates and their implications for drug development in Alzheimer's disease. , 2011, Current topics in medicinal chemistry.

[48]  T. Pierfelice,et al.  Notch in the Vertebrate Nervous System: An Old Dog with New Tricks , 2011, Neuron.

[49]  A. Arthur,et al.  A method to isolate and culture expand human dental pulp stem cells. , 2011, Methods in molecular biology.

[50]  E. Tan,et al.  Notch as a molecular switch in neural stem cells , 2010, IUBMB life.

[51]  A. Hampl,et al.  Inhibition of Notch Signaling in Human Embryonic Stem Cell–Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo , 2010, Stem cells.

[52]  K. Mori,et al.  Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains , 2010, The Journal of Neuroscience.

[53]  G. Varga,et al.  Differentiation potential of stem cells from human dental origin - promise for tissue engineering. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[54]  M. Wolfe Intramembrane-cleaving Proteases* , 2009, Journal of Biological Chemistry.

[55]  Z. Valić,et al.  Blockade of 5-HT(1A) receptors in the phrenic nucleus of the rat attenuated raphe induced activation of the phrenic nerve activity. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[56]  Janghwan Kim,et al.  Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells , 2009, BMC Neuroscience.

[57]  J. Kerr-Conte,et al.  Human dental pulp stem cells differentiate into neural crest-derived melanocytes and have label-retaining and sphere-forming abilities. , 2008, Stem cells and development.

[58]  S. Gronthos,et al.  Adult Human Dental Pulp Stem Cells Differentiate Toward Functionally Active Neurons Under Appropriate Environmental Cues , 2008, Stem cells.

[59]  S. Shi,et al.  Inhibition of Human Dental Pulp Stem Cell Differentiation by Notch Signaling , 2008, Journal of dental research.

[60]  Sally Lowell,et al.  Notch Promotes Neural Lineage Entry by Pluripotent Embryonic Stem Cells , 2006, PLoS biology.

[61]  Brent A Reynolds,et al.  Neural stem cell isolation and characterization. , 2006, Methods in enzymology.

[62]  D. Prockop,et al.  Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. , 2006, Cytotherapy.

[63]  W. Gordon,et al.  Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation , 2005, The Journal of experimental medicine.

[64]  Ryoichiro Kageyama,et al.  Roles of bHLH genes in neural stem cell differentiation. , 2005, Experimental cell research.

[65]  N. Gaiano,et al.  Notch signaling in the mammalian central nervous system: insights from mouse mutants , 2005, Nature Neuroscience.

[66]  K. Schlett,et al.  Stage-dependent effects of cell-to-cell connections on in vitro induced neurogenesis. , 2002, European journal of cell biology.

[67]  T. Vicsek,et al.  Dynamics of cell aggregation during in vitro neurogenesis by immortalized neuroectodermal progenitors , 2000, Journal of neuroscience research.

[68]  T. Ohtsuka,et al.  Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation , 1999, The EMBO journal.