Analytical techniques of drug polymorphs and their applications

The phenomenon of solid drug polymorphs is a widespread natural phenomenon.It has become one of the most important problems in the development and production process,and will directly affect the drug's performance,quality,safety and clinical efficacy.In order to discover the formation mechanism of polymorphs and improve the stability,a further microscopic study of the system is necessary.In this paper,we reviewed the conventional analytical techniques in the study of drug polymorphs,the recent emergence of new technologies and new methods,and summarized the range of applications of the various methods and technology developments.