Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing

[1]  Nicholas Medcalf,et al.  Cell therapy-processing economics: small-scale microfactories as a stepping stone toward large-scale macrofactories. , 2018, Regenerative medicine.

[2]  Lei Yang,et al.  Melatonin protects bone marrow mesenchymal stem cells against iron overload‐induced aberrant differentiation and senescence , 2017, Journal of pineal research.

[3]  Q. Rafiq,et al.  Decentralized manufacturing of cell and gene therapies: Overcoming challenges and identifying opportunities. , 2017, Cytotherapy.

[4]  C. Tufarelli,et al.  Expression of a SOX1 overlapping transcript in neural differentiation and cancer models , 2017, Cellular and Molecular Life Sciences.

[5]  Sheng Lin-Gibson,et al.  Manufacturing Cell Therapies: The Paradigm Shift in Health Care of This Century , 2017 .

[6]  K. Roy,et al.  Perspectives on Manufacturing of High-Quality Cell Therapies. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[7]  Matteo Santin,et al.  Rapid and efficient magnetization of mesenchymal stem cells by dendrimer-functionalized magnetic nanoparticles. , 2016, Nanomedicine.

[8]  A. E. El Haj,et al.  Autonomous magnetic labelling of functional mesenchymal stem cells for improved traceability and spatial control in cell therapy applications , 2016, Journal of tissue engineering and regenerative medicine.

[9]  T. Trouard,et al.  Effects of the iron oxide nanoparticle Molday ION Rhodamine B on the viability and regenerative function of neural stem cells: relevance to clinical translation , 2016, International journal of nanomedicine.

[10]  P. A. Lima,et al.  Effective Hypothermic Storage of Human Pluripotent Stem Cell‐Derived Cardiomyocytes Compatible With Global Distribution of Cells for Clinical Applications and Toxicology Testing , 2016, Stem cells translational medicine.

[11]  Nick Medcalf,et al.  Automating decentralized manufacturing of cell and gene therapy products. , 2016 .

[12]  L. Madhavan Redox-based regulation of neural stem cell function and Nrf2. , 2015, Biochemical Society transactions.

[13]  J. Dobson,et al.  An in vitro model of mesenchymal stem cell targeting using magnetic particle labelling , 2015, Journal of tissue engineering and regenerative medicine.

[14]  Bo Kara,et al.  The translation of cell-based therapies: clinical landscape and manufacturing challenges. , 2015, Regenerative medicine.

[15]  B. Cui,et al.  Chemically Defined and Small Molecule-Based Generation of Human Cardiomyocytes , 2014, Nature methods.

[16]  David J. Williams,et al.  Regulatory challenges for the manufacture and scale-out of autologous cell therapies , 2014 .

[17]  K. Coopman,et al.  From production to patient: challenges and approaches for delivering cell therapies , 2014 .

[18]  A. Rustgi,et al.  Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems , 2013, Stem Cell Research & Therapy.

[19]  Jelena Kolosnjaj-Tabi,et al.  Cell labeling with magnetic nanoparticles: Opportunity for magnetic cell imaging and cell manipulation , 2013, Journal of Nanobiotechnology.

[20]  Jin Suo,et al.  Magnetic targeting of human mesenchymal stem cells with internalized superparamagnetic iron oxide nanoparticles. , 2013, Small.

[21]  P. Padmanabhan,et al.  Multifunctional Iron Oxide Nanoparticles for Diagnostics, Therapy and Macromolecule Delivery , 2013, Theranostics.

[22]  Morteza Mahmoudi,et al.  Exocytosis of nanoparticles from cells: role in cellular retention and toxicity. , 2013, Advances in colloid and interface science.

[23]  A. E. El Haj,et al.  Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells – a rheumatoid arthritis mouse model , 2013, Stem Cell Research & Therapy.

[24]  I. In,et al.  Recyclable and stable silver deposited magnetic nanoparticles with poly (vinyl pyrrolidone)-catechol coated iron oxide for antimicrobial activity. , 2013, Materials science & engineering. C, Materials for biological applications.

[25]  A. S. Simaria,et al.  Allogeneic Cell Therapy Bioprocess Economics and Optimization: Single-Use Cell Expansion Technologies , 2013, Biotechnology and bioengineering.

[26]  Yoram Cohen,et al.  Magnetic nanoparticles-based diagnostics and theranostics. , 2013, Current opinion in biotechnology.

[27]  Z. Gu,et al.  Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive Stem Cell Labeling and Tracking , 2013, Theranostics.

[28]  Roberto Cingolani,et al.  Subnanometer local temperature probing and remotely controlled drug release based on azo-functionalized iron oxide nanoparticles. , 2013, Nano letters.

[29]  Zhuang Liu,et al.  Multifunctional Upconversion Nanoparticles for Dual‐Modal Imaging‐Guided Stem Cell Therapy under Remote Magnetic Control , 2013 .

[30]  Ventola Cl The Nanomedicine Revolution: Part 2: Current and Future Clinical Applications , 2012 .

[31]  G. Bates,et al.  Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington’s disease , 2012, BMC Neuroscience.

[32]  U. Häfeli,et al.  Focused Magnetic Stem Cell Targeting to the Retina Using Superparamagnetic Iron Oxide Nanoparticles , 2012, Cell transplantation.

[33]  Lucía Gutiérrez,et al.  Biological applications of magnetic nanoparticles. , 2012, Chemical Society reviews.

[34]  A. E. El Haj,et al.  Orthopaedic applications of nanoparticle-based stem cell therapies , 2012, Stem Cell Research & Therapy.

[35]  B. Grinblat,et al.  Evaluation of bone marrow-derived mesenchymal stem cells after cryopreservation and hypothermic storage in clinically safe medium. , 2012, Tissue engineering. Part C, Methods.

[36]  Rhodri Ceredig,et al.  When one cell is enough , 2012, Stem Cell Research & Therapy.

[37]  Urs O. Häfeli,et al.  Crucial Ignored Parameters on Nanotoxicology: The Importance of Toxicity Assay Modifications and “Cell Vision” , 2012, PloS one.

[38]  Kevin S. Tang,et al.  On the Use of Micron-Sized Iron Oxide Particles (MPIOS) to Label Resting Monocytes in Bone Marrow , 2011, Molecular Imaging and Biology.

[39]  M. Ochi,et al.  Therapeutic Effects With Magnetic Targeting of Bone Marrow Stromal Cells in a Rat Spinal Cord Injury Model , 2011, Spine.

[40]  Morteza Mahmoudi,et al.  Effect of nanoparticles on the cell life cycle. , 2011, Chemical reviews.

[41]  Victor S-Y Lin,et al.  Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects. , 2011, ACS nano.

[42]  J. Bulte,et al.  Long‐term MR cell tracking of neural stem cells grafted in immunocompetent versus immunodeficient mice reveals distinct differences in contrast between live and dead cells , 2011, Magnetic resonance in medicine.

[43]  R. Amal,et al.  Stabilization of magnetic iron oxide nanoparticles in biological media by fetal bovine serum (FBS). , 2011, Langmuir : the ACS journal of surfaces and colloids.

[44]  Anthony N Price,et al.  Targeted magnetic delivery and tracking of cells using a magnetic resonance imaging system. , 2010, Biomaterials.

[45]  Heinz-Peter Schlemmer,et al.  Functional investigations on human mesenchymal stem cells exposed to magnetic fields and labeled with clinically approved iron nanoparticles , 2010, BMC Cell Biology.

[46]  Q. Pankhurst,et al.  Progress in applications of magnetic nanoparticles in biomedicine , 2009 .

[47]  Nicholas E. Timmins,et al.  Clinical scale ex vivo manufacture of neutrophils from hematopoietic progenitor cells , 2009, Biotechnology and bioengineering.

[48]  Pauliina Lehtolainen,et al.  Magnetic tagging increases delivery of circulating progenitors in vascular injury. , 2009, JACC. Cardiovascular interventions.

[49]  Chia-Ying Lin,et al.  Characterization of stem cell attributes in human osteosarcoma cell lines , 2009, Cancer biology & therapy.

[50]  M. Cotrufo,et al.  Mesenchymal stem cells effectively reduce surgically induced stenosis in rat carotids , 2008, Journal of cellular physiology.

[51]  S. Totey,et al.  Effect of holding time, temperature and different parenteral solutions on viability and functionality of adult bone marrow‐derived mesenchymal stem cells before transplantation , 2008, Journal of tissue engineering and regenerative medicine.

[52]  Gary Friedman,et al.  High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents , 2008, Proceedings of the National Academy of Sciences.

[53]  A. Rosengart,et al.  Capture of magnetic carriers within large arteries using external magnetic fields* , 2008 .

[54]  W. Stanford,et al.  Late-Outgrowth Endothelial Cells Attenuate Intimal Hyperplasia Contributed by Mesenchymal Stem Cells After Vascular Injury , 2007, Arteriosclerosis, Thrombosis and Vascular Biology.

[55]  Klaas Nicolay,et al.  MRI contrast agents: current status and future perspectives. , 2007, Anti-cancer agents in medicinal chemistry.

[56]  Hiroyuki Honda,et al.  Construction of multi‐layered cardiomyocyte sheets using magnetite nanoparticles and magnetic force , 2007, Biotechnology and bioengineering.

[57]  Rajiv Gulati,et al.  Magnetically targeted endothelial cell localization in stented vessels. , 2006, Journal of the American College of Cardiology.

[58]  S. Yanada,et al.  Magnetic targeting of bone marrow stromal cells into spinal cord: through cerebrospinal fluid , 2006, Neuroreport.

[59]  J. Dobson,et al.  Magnetic micro- and nanoparticle mediated activation of mechanosensitive ion channels. , 2005, Medical engineering & physics.

[60]  H. Honda,et al.  Construction and delivery of tissue-engineered human retinal pigment epithelial cell sheets, using magnetite nanoparticles and magnetic force. , 2005, Tissue engineering.

[61]  Steven P Gygi,et al.  Large-scale characterization of HeLa cell nuclear phosphoproteins. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[62]  Alan P Koretsky,et al.  MRI detection of single particles for cellular imaging. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[63]  É. Duguet,et al.  Magnetic nanoparticle design for medical diagnosis and therapy , 2004 .

[64]  Bobbi K Lewis,et al.  In vivo trafficking and targeted delivery of magnetically labeled stem cells. , 2004, Human gene therapy.

[65]  Elliot R. McVeigh,et al.  Magnetic Resonance Fluoroscopy Allows Targeted Delivery of Mesenchymal Stem Cells to Infarct Borders in Swine , 2003, Circulation.

[66]  Jeff W M Bulte,et al.  Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. , 2003, Radiology.

[67]  Alan P Koretsky,et al.  Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. , 2003, Blood.

[68]  Q. Pankhurst,et al.  TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine , 2003 .

[69]  C. Bárcena,et al.  APPLICATIONS OF MAGNETIC NANOPARTICLES IN BIOMEDICINE , 2003 .

[70]  J. B. Kneeland,et al.  Proteoglycan‐induced changes in T1ρ‐relaxation of articular cartilage at 4T , 2001, Magnetic resonance in medicine.

[71]  W. Zauner,et al.  In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[72]  J. B. Kneeland,et al.  Sensitivity of MRI to proteoglycan depletion in cartilage: comparison of sodium and proton MRI. , 2000, Osteoarthritis and cartilage.

[73]  Gordon L. Amidon,et al.  The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent , 1997, Pharmaceutical Research.

[74]  Thomas J. Raub,et al.  Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. , 1989, Gastroenterology.

[75]  B. Spengler,et al.  Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. , 1973, Cancer research.

[76]  R. Gilchrist,et al.  Selective Inductive Heating of Lymph Nodes , 1957, Annals of surgery.

[77]  A. Glover,et al.  Magnetic Heating of Iron Oxide Nanoparticles and Magnetic Micelles for Cancer Therapy , 2013, IEEE Transactions on Magnetics.

[78]  A. E. Haj,et al.  Biocompatibility and toxicity of magnetic nanoparticles in regenerative medicine , 2012 .

[79]  Jon A. Rowley,et al.  Meeting Lot-Size Challenges of Manufacturing Adherent Cells for Therapy , 2012 .

[80]  C. L. Ventola The nanomedicine revolution: part 2: current and future clinical applications. , 2012, P & T : a peer-reviewed journal for formulary management.

[81]  Jai Singh,et al.  Nanomaterials for light management in electro-optical devices , 2012 .

[82]  Juan L. Vivero-Escoto,et al.  Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells. , 2009, Small.

[83]  A. Tsourkas,et al.  Imaging circulating cells and lymphoid tissues with iron oxide nanoparticles. , 2009, Hematology. American Society of Hematology. Education Program.

[84]  D. Rowe,et al.  Examination of Mineralized Nodule Formation in Living Osteoblastic Cultures Using Fluorescent Dyes , 2006, Biotechnology progress.

[85]  Virginie Sottile,et al.  In vitro osteogenic differentiation of human ES cells. , 2003, Cloning and stem cells.