Nutrient Biomarker Patterns, Cognitive Function, and Mri Measures of Brain Aging

Recently, Bowman et al.1 reported that a plasma nutrient pattern rich in vitamin D was associated with better cognition and larger brain volume on MRI in older community dwellers. Despite comprehensively estimating nutrients, such studies could be enhanced by measuring regional volumes rather than whole-brain volume to identify specific brain areas protected by vitamins. Since structural brain changes manifest long before cognitive symptoms, accurate morphometric approaches are crucial.2 Current automated segmentation algorithms can determine the volume of different regions of interest,3 which may help to clarify …