Clinical, Histologic, and Computed Tomographic Features of Oral Papillary Squamous Cell Carcinoma in Dogs: 9 Cases (2008–2011)

Medical records of dogs diagnosed with oral papillary squamous cell carcinoma between December 2008 and April 2011 were reviewed. Information abstracted included signalment, tumor location, tumor size, computed tomographic (CT) features, evidence of metastatic disease based on cytologic examination of lymph node aspirates and thoracic radiography, treatment, surgical margins, histologic features, and treatment outcome. Dogs included in the study were all sexually altered, predominantly large breed dogs with a mean age of 3.9-years (range, 0.5 to 9.0-years). The most common location was the rostral maxilla. Invasion of underlying bone and lymphadenopathy were evident on CT imaging in most dogs. No evidence of metastasis was found on mandibular lymph node cytology and thoracic radiography. Histologic analysis revealed similar morphologic findings for all surgically resected tumors. Surgical excision with 1–2 cm margins was complete in all cases, with a mean tumor-free interval of 12.1-months.

[1]  J. Russell,et al.  Papillary squamous cell carcinoma of the head and neck: a clinicopathologic series. , 2011, American journal of otolaryngology.

[2]  M. Brunotto,et al.  Relationship between chronic trauma of the oral mucosa, oral potentially malignant disorders and oral cancer. , 2010, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[3]  J. R. Lewis,et al.  Computed tomographic features of oral squamous cell carcinoma in cats: 18 cases (2002-2008). , 2010, Journal of the American Veterinary Medical Association.

[4]  S. Llorente,et al.  Oral carcinoma associated with implant-supported overdenture trauma: a case report. , 2009, Dental traumatology : official publication of International Association for Dental Traumatology.

[5]  S. Sudha,et al.  Squamous cell carcinoma of tongue in a 19-year-old female. , 2008, Indian journal of cancer.

[6]  S. Withrow,et al.  Chapter 21 – Cancer of the Gastrointestinal Tract , 2007 .

[7]  Tumours of the Hypopharynx , Larynx and Trachea , 2007 .

[8]  M. Mueller.  Inflammation in epithelial skin tumours: old stories and new ideas. , 2006, European journal of cancer.

[9]  S. Zunt,et al.  Papillary squamous cell carcinoma presenting on the gingiva. , 2005, Journal of periodontology.

[10]  M. Callan,et al.  Multiple papillomavirus-associated epidermal hamartomas and squamous cell carcinomas in situ in a dog following chronic treatment with prednisone and cyclosporine. , 2005, Veterinary dermatology.

[11]  M. Itoiz,et al.  An experimental model to demonstrate the carcinogenic action of oral chronic traumatic ulcer. , 2005, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[12]  D. Meuten.  Histological classification of tumors of the urinary system of domestic animals , 2004 .

[13]  D. Knapp,et al.  Phase I trial of piroxicam in 62 dogs bearing naturally occurring tumors , 2004, Cancer Chemotherapy and Pharmacology.

[14]  C. O'brien,et al.  Influence of condition of surgical margins on local recurrence and disease-specific survival in oral and oropharyngeal cancer. , 2003, The British journal of oral & maxillofacial surgery.

[15]  D. Knapp,et al.  Evaluation of piroxicam for the treatment of oral squamous cell carcinoma in dogs. , 2001, Journal of the American Veterinary Medical Association.

[16]  J G Batsakis,et al.  Surgical excision margins: a pathologist's perspective. , 1999, Advances in anatomic pathology.

[17]  J. Cullen,et al.  Histological Classification of Tumors of the Genital System of Domestic Animals , 1998 .

[18]  G. Barrington,et al.  Squamous cell carcinoma originating from a cutaneous scar in a llama. , 1997, The Canadian veterinary journal = La revue veterinaire canadienne.

[19]  Craig S. Miller,et al.  Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma: a retrospective review of the literature. , 1996, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[20]  B. L. Stapleton,et al.  Papillary Squamous Cell Carcinoma in a Young Dog , 1996, Journal of veterinary dentistry.

[21]  T. Sato.  [A study on effect of mechanical irritation in development and progression of tongue cancer]. , 1995, Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan.

[22]  A. Barasch,et al.  Squamous cell carcinoma of the gingiva. A case series analysis. , 1995, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[23]  A. Ishiyama,et al.  Papillary squamous neoplasms of the head and neck , 1994, The Laryngoscope.

[24]  R. Martin.  Incisional versus excisional biopsy. , 1993, Seminars in veterinary medicine and surgery.

[25]  J. Sundberg,et al.  Papillary squamous cell carcinoma in three young dogs. , 1988, Journal of the American Veterinary Medical Association.

[26]  van Rensburg Ib.  Oral verrucous carcinoma in two dogs. , 1982 .

[27]  A. Konstantinidis,et al.  Tumorigenesis at a predetermined oral site after one intraperitoneal injection of N-nitroso-N-methylurea. , 1982, Science.

[28]  M. T. Case,et al.  Canine papilloma: progression of oral papilloma to carcinoma. , 1970, Journal of the National Cancer Institute.