Dietary Patterns, Foods, and Nutrients to Ameliorate Non-Alcoholic Fatty Liver Disease: A Scoping Review

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease without pharmacological treatment yet. There is also a lack of specific dietary recommendations and strategies to treat the negative health impacts derived from NAFLD. Objective: This scoping review aimed to compile dietary patterns, foods, and nutrients to ameliorate NAFLD. Methods: A literature search was performed through MEDLINE, Scopus, Web of Science, and Google Scholar. Results: Several guidelines are available through the literature. Hypocaloric Mediterranean diet is the most accepted dietary pattern to tackle NAFLD. Coffee consumption (sugar free) may have a protective effect for NAFLD. Microbiota also plays a role in NAFLD; hence, fibre intake should be guaranteed. Conclusions: A high-quality diet could improve liver steatosis. Weight loss through hypocaloric diet together with physical activity and limited sugar intake are good strategies for managing NAFLD. Specific dietary recommendations and a Mediterranean plate have been proposed to ameliorate NAFLD.

[1]  A. Sureda,et al.  Plasma Fatty Acid Composition, Oxidative and Inflammatory Status, and Adherence to the Mediterranean Diet of Patients with Non-Alcoholic Fatty Liver Disease , 2023, Antioxidants.

[2]  Zhaoxi Zhou,et al.  Exocarpium Citri Grandis alleviates the aggravation of NAFLD by mitigating lipid accumulation and iron metabolism disorders. , 2023, Journal of ethnopharmacology.

[3]  A. Sureda,et al.  Mediterranean Diet Improves Plasma Biomarkers Related to Oxidative Stress and Inflammatory Process in Patients with Non-Alcoholic Fatty Liver Disease , 2023, Antioxidants.

[4]  Junrui Cheng,et al.  Carotenoids in orange carrots mitigate non-alcoholic fatty liver disease progression , 2022, Frontiers in Nutrition.

[5]  R. Tabrizi,et al.  Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort study , 2022, Frontiers in Nutrition.

[6]  J. Tur,et al.  Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study , 2022, Nutrients.

[7]  A. Sureda,et al.  Increased Adherence to the Mediterranean Diet after Lifestyle Intervention Improves Oxidative and Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease , 2022, Antioxidants.

[8]  F. Underwood,et al.  The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. , 2022, The lancet. Gastroenterology & hepatology.

[9]  A. Sureda,et al.  A Greater Improvement of Intrahepatic Fat Contents after 6 Months of Lifestyle Intervention Is Related to a Better Oxidative Stress and Inflammatory Status in Non-Alcoholic Fatty Liver Disease , 2022, Antioxidants.

[10]  I. Szanto,et al.  NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 Diabetes: Current Knowledge and Therapeutic Outlook , 2022, Antioxidants.

[11]  M. del Ben,et al.  Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic Syndrome: A Narrative Review , 2022, Nutrients.

[12]  V. Cantaluppi,et al.  Oxidative Stress in Non-Alcoholic Fatty Liver Disease , 2022, Livers.

[13]  A. Hekmatdoost,et al.  Red and Processed Meat Intake in Relation to Non-Alcoholic Fatty Liver Disease Risk: Results from a Case-Control Study , 2022, Clinical nutrition research.

[14]  Xuehong Zhang,et al.  Red Meat Consumption, Obesity, and the Risk of Nonalcoholic Fatty Liver Disease among Women: Evidence from Mediation Analysis , 2021, Clinical Nutrition.

[15]  R. Malekzadeh,et al.  The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge? , 2021, Journal of hepatology.

[16]  Yu-Jin Kwon,et al.  Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease. , 2021, Clinical nutrition.

[17]  A. Patterson,et al.  Coffee Consumption and the Progression of NAFLD: A Systematic Review , 2021, Nutrients.

[18]  M. Roden,et al.  The complex link between NAFLD and type 2 diabetes mellitus — mechanisms and treatments , 2021, Nature Reviews Gastroenterology & Hepatology.

[19]  P. O’Toole,et al.  Dietary Fibre Modulates the Gut Microbiota , 2021, Nutrients.

[20]  Weixuan Wang,et al.  Role of 2-series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non-alcoholic fatty liver disease (Review) , 2021, International journal of molecular medicine.

[21]  Chengfu Xu,et al.  Low serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study , 2021, Nutrition Journal.

[22]  K. Aleksandrova,et al.  Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies , 2021, Redox biology.

[23]  U. Huber-Schönauer,et al.  Nut consumption and the prevalence and severity of non-alcoholic fatty liver disease , 2020, PloS one.

[24]  Zhijian Hu,et al.  Association of meat consumption with NAFLD risk and liver-related biochemical indexes in older Chinese: a cross-sectional study , 2020, BMC Gastroenterology.

[25]  M. Surette,et al.  High Fat-High Fructose Diet-Induced Changes in the Gut Microbiota Associated with Dyslipidemia in Syrian Hamsters , 2020, Nutrients.

[26]  V. Wong,et al.  The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease , 2020, Hepatology International.

[27]  Seong-Ah Kim,et al.  Fruit and vegetable consumption and non-alcoholic fatty liver disease among Korean adults: a prospective cohort study , 2020, Journal of Epidemiology & Community Health.

[28]  J. Martínez,et al.  Oxidative Stress and Pro-Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease , 2020, Antioxidants.

[29]  R. Meex,et al.  Mitochondrial Dysfunction is a Key Pathway that Links Saturated Fat Intake to the Development and Progression of NAFLD , 2020, Molecular nutrition & food research.

[30]  F. Magne,et al.  The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients? , 2020, Nutrients.

[31]  M. Goodman,et al.  Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver Cirrhosis , 2020, Nutrients.

[32]  H. Tilg,et al.  NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications , 2020, Gut.

[33]  G. Berná,et al.  The role of nutrition in non‐alcoholic fatty liver disease: Pathophysiology and management , 2020, Liver international : official journal of the International Association for the Study of the Liver.

[34]  G. Caire-Juvera,et al.  Diet, physical activity and telomere length in adults. , 2019, Nutricion hospitalaria.

[35]  F. De Chiara,et al.  High Protein Diet and Metabolic Plasticity in Non-Alcoholic Fatty Liver Disease: Myths and Truths , 2019, Nutrients.

[36]  M. Zheng,et al.  A systematic review and a dose-response meta-analysis of coffee dose and nonalcoholic fatty liver disease. , 2019, Clinical nutrition.

[37]  E. Latz,et al.  Western Diet and the Immune System: An Inflammatory Connection. , 2019, Immunity.

[38]  F. Carrilho,et al.  IMPACT OF CURRENT DIET AT THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD). , 2019, Arquivos de gastroenterologia.

[39]  Shunming Zhang,et al.  Association between habitual yogurt consumption and newly diagnosed non-alcoholic fatty liver disease , 2019, European Journal of Clinical Nutrition.

[40]  M. Melamed,et al.  The Effects of Dairy Intake on Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Clinical Trials , 2019, Nutrients.

[41]  L. Rink,et al.  Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials. , 2019, The American journal of clinical nutrition.

[42]  Jian-Gao Fan,et al.  Microbial metabolites in non-alcoholic fatty liver disease , 2019, World journal of gastroenterology.

[43]  Takeshi Kimura,et al.  No association between fruits or vegetables and non-alcoholic fatty liver disease in middle-aged men and women. , 2019, Nutrition.

[44]  S. Bischoff,et al.  Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases , 2019, Aktuelle Ernährungsmedizin.

[45]  M. Plauth,et al.  ESPEN guideline on clinical nutrition in liver disease. , 2019, Clinical nutrition.

[46]  G. Frühbeck,et al.  Impact of Nutritional Changes on Nonalcoholic Fatty Liver Disease , 2019, Nutrients.

[47]  H. Poustchi,et al.  Legume intake and risk of nonalcoholic fatty liver disease , 2019, Indian Journal of Gastroenterology.

[48]  N. Wareham,et al.  The association between adherence to the Mediterranean diet and hepatic steatosis: cross-sectional analysis of two independent studies, the UK Fenland Study and the Swiss CoLaus Study , 2019, BMC Medicine.

[49]  M. Hariri,et al.  Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Clinical Trials , 2019, International journal of preventive medicine.

[50]  S. Asch,et al.  Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease. , 2018, Gastroenterology.

[51]  A. Lonardo,et al.  Telomere shortening: An innocent bystander at the crossroad of NASH with ageing and cardiometabolic risk? , 2018, Liver international : official journal of the International Association for the Study of the Liver.

[52]  A. Safaiyan,et al.  Pro- and prebiotic effects on oxidative stress and inflammatory markers in non-alcoholic fatty liver disease. , 2018, Asia Pacific journal of clinical nutrition.

[53]  R. Carr,et al.  Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis , 2018, Cellular and molecular gastroenterology and hepatology.

[54]  O. Franco,et al.  Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: the Rotterdam Study , 2018, Gut.

[55]  S. Darwish Murad,et al.  Potential Mechanisms Underlying the Role of Coffee in Liver Health , 2018, Seminars in Liver Disease.

[56]  B. Neuschwander‐Tetri,et al.  Mechanisms of NAFLD development and therapeutic strategies , 2018, Nature Medicine.

[57]  M. Alizadeh,et al.  Daily Consumption of Synbiotic Yogurt Decreases Liver Steatosis in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial. , 2018, The Journal of nutrition.

[58]  M. Hernán,et al.  Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra‐Virgin Olive Oil or Nuts , 2018, The New England journal of medicine.

[59]  R. V. Gonçalves,et al.  Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids. , 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[60]  O. Shibolet,et al.  High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance. , 2018, Journal of hepatology.

[61]  J. Gunton,et al.  Vitamin D and the Liver—Correlation or Cause? , 2018, Nutrients.

[62]  M. Szychlinska,et al.  Impact of Western and Mediterranean Diets and Vitamin D on Muscle Fibers of Sedentary Rats , 2018, Nutrients.

[63]  Michael Charlton,et al.  The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases , 2018, Hepatology.

[64]  S. Neubauer,et al.  Hepatic iron is the major determinant of serum ferritin in NAFLD patients , 2018, Liver international : official journal of the International Association for the Study of the Liver.

[65]  L. Videla,et al.  Liver Protective Effects of Extra Virgin Olive Oil: Interaction between Its Chemical Composition and the Cell-signaling Pathways Involved in Protection. , 2017, Endocrine, metabolic & immune disorders drug targets.

[66]  M. Ekstedt,et al.  Natural History of NAFLD/NASH , 2017, Current Hepatology Reports.

[67]  Vincent Wai-Sun Wong,et al.  New trends on obesity and NAFLD in Asia. , 2017, Journal of hepatology.

[68]  Mi-kyung Kim,et al.  Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway , 2017, Oncotarget.

[69]  P. Tandon,et al.  Dietary Composition Independent of Weight Loss in the Management of Non-Alcoholic Fatty Liver Disease , 2017, Nutrients.

[70]  F. Azizi,et al.  Relationship between Diet and Non-alcoholic Fatty Liver Disease: A Review Article , 2017, Iranian journal of public health.

[71]  S. Zelber-Sagi,et al.  The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms , 2017, Liver international : official journal of the International Association for the Study of the Liver.

[72]  A. Duffy,et al.  Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes. , 2017, The Journal of nutrition.

[73]  F. Violi,et al.  Extra virgin olive oil improves post-prandial glycemic and lipid profile in patients with impaired fasting glucose. , 2017, Clinical nutrition.

[74]  S. Sookoian,et al.  Systematic review with meta‐analysis: risk factors for non‐alcoholic fatty liver disease suggest a shared altered metabolic and cardiovascular profile between lean and obese patients , 2017, Alimentary pharmacology & therapeutics.

[75]  O. Varlamov Western-style diet, sex steroids and metabolism. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[76]  E. Paschetta,et al.  TM6SF2 rs58542926 variant affects postprandial lipoprotein metabolism and glucose homeostasis in NAFLD[S] , 2017, Journal of Lipid Research.

[77]  C. Thongprayoon,et al.  Coffee consumption and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis , 2017, European journal of gastroenterology & hepatology.

[78]  P. Calder,et al.  Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids. , 2017, Clinical nutrition.

[79]  V. Wong,et al.  Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients , 2017, Hepatology.

[80]  Robert Blissett,et al.  The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe , 2016, Hepatology.

[81]  D. Crawford,et al.  Iron and non-alcoholic fatty liver disease , 2016, World journal of gastroenterology.

[82]  A. Feizi,et al.  Intake of Nutrients, Fiber, and Sugar in Patients with Nonalcoholic Fatty Liver Disease in Comparison to Healthy Individuals , 2016, International journal of preventive medicine.

[83]  J. Plaza-Díaz,et al.  Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials , 2016, International journal of molecular sciences.

[84]  Charles N. Serhan,et al.  Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition. , 2016, Journal of nutrigenetics and nutrigenomics.

[85]  H. Tilg,et al.  EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease , 2016, Obesity Facts.

[86]  M. Chonchol,et al.  NAFLD and Chronic Kidney Disease , 2016, International journal of molecular sciences.

[87]  Z. Younossi,et al.  Non-alcoholic Fatty Liver Disease (NAFLD) is associated with impairment of Health Related Quality of Life (HRQOL) , 2016, Health and Quality of Life Outcomes.

[88]  O. Izaola,et al.  MEDITERRANEAN DIET IS ASSOCIATED WITH LIVER HISTOLOGY IN PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE. , 2015, Nutricion hospitalaria.

[89]  D. van der Poorten,et al.  Oily fish, coffee and walnuts: Dietary treatment for nonalcoholic fatty liver disease. , 2015, World journal of gastroenterology.

[90]  E. Kang,et al.  Sarcopaenia is associated with NAFLD independently of obesity and insulin resistance: Nationwide surveys (KNHANES 2008-2011). , 2015, Journal of hepatology.

[91]  C. Fox,et al.  Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts. , 2015, Journal of hepatology.

[92]  F. Violi,et al.  Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects , 2015, Nutrition & Diabetes.

[93]  M. Budoff,et al.  The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). , 2015, Atherosclerosis.

[94]  Zamir Halpern,et al.  Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population. , 2015, Translational research : the journal of laboratory and clinical medicine.

[95]  Jaimie N. Davis,et al.  Vegetable consumption is linked to decreased visceral and liver fat and improved insulin resistance in overweight Latino youth. , 2014, Journal of the Academy of Nutrition and Dietetics.

[96]  Y. Manios,et al.  Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease. , 2014, Clinical nutrition.

[97]  Glenn R. Gibson,et al.  The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic , 2014 .

[98]  Anne Tybjærg-Hansen,et al.  Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease , 2014, Nature Genetics.

[99]  F. Hu,et al.  Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies , 2014, Circulation.

[100]  Y. Chawla,et al.  Obesity and NAFLD: the role of bacteria and microbiota. , 2014, Clinics in liver disease.

[101]  F. Hu,et al.  Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis , 2014, Diabetes Care.

[102]  L. N. Valenti,et al.  PNPLA3 I148M polymorphism and progressive liver disease. , 2013, World journal of gastroenterology.

[103]  A. Hatzitolios,et al.  Potential treatment of human nonalcoholic fatty liver disease with long-chain omega-3 polyunsaturated fatty acids. , 2013, Nutrition reviews.

[104]  Yoosoo Chang,et al.  Sleep duration and quality in relation to non-alcoholic fatty liver disease in middle-aged workers and their spouses. , 2013, Journal of hepatology.

[105]  B. Neuschwander‐Tetri,et al.  Vitamin E and changes in serum alanine aminotransferase levels in patients with non‐alcoholic steatohepatitis , 2013, Alimentary pharmacology & therapeutics.

[106]  G. Ward,et al.  The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease. , 2013, Journal of hepatology.

[107]  K. Oishi,et al.  Influence of coffee (Coffea arabica) and galacto-oligosaccharide consumption on intestinal microbiota and the host responses. , 2013, FEMS microbiology letters.

[108]  J. P. Pêgas Henriques,et al.  The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability , 2013, BioMed research international.

[109]  L. Beilin,et al.  The Western Dietary Pattern Is Prospectively Associated With Nonalcoholic Fatty Liver Disease in Adolescence , 2013, The American Journal of Gastroenterology.

[110]  M. Vinciguerra,et al.  Redox homeostasis and epigenetics in non-alcoholic fatty liver disease (NAFLD). , 2013, Current pharmaceutical design.

[111]  G. Musso,et al.  Association of obstructive sleep apnoea with the presence and severity of non‐alcoholic fatty liver disease. A systematic review and meta‐analysis , 2013, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[112]  L. Afman,et al.  Phenotyping the effect of diet on non-alcoholic fatty liver disease. , 2012, Journal of hepatology.

[113]  J. Gugenheim,et al.  Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery. , 2012, Journal of hepatology.

[114]  Chun-Jen Liu Prevalence and risk factors for non‐alcoholic fatty liver disease in Asian people who are not obese , 2012, Journal of gastroenterology and hepatology.

[115]  Jeanne M Clark,et al.  Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes , 2012, Hepatology.

[116]  S. Carvalhana,et al.  Improving dietary patterns in patients with nonalcoholic fatty liver disease , 2012, Current opinion in clinical nutrition and metabolic care.

[117]  S. Sookoian,et al.  Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease , 2012, Gut.

[118]  L. Peyrin-Biroulet,et al.  Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver. , 2012, Journal of hepatology.

[119]  S. Caprio,et al.  Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake , 2012, PloS one.

[120]  K. Rioux,et al.  The potential role of prebiotic fibre for treatment and management of non‐alcoholic fatty liver disease and associated obesity and insulin resistance , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[121]  S. Zeisel,et al.  Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression , 2012, Current opinion in gastroenterology.

[122]  M. Stepanova,et al.  Caffeine is protective in patients with non‐alcoholic fatty liver disease , 2012, Alimentary pharmacology & therapeutics.

[123]  A. Trichopoulou,et al.  Mediterranean diet pyramid today. Science and cultural updates , 2011, Public Health Nutrition.

[124]  P. Casas-Agustench,et al.  Mediterranean nuts: origins, ancient medicinal benefits and symbolism , 2011, Public Health Nutrition.

[125]  Chao-Long Chen,et al.  Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. , 2011, Journal of hepatology.

[126]  R. DiSilvestro,et al.  Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; a pilot clinical study with phytochemical and in vitro antioxidant characterization , 2011, Nutrition journal.

[127]  J. O’Keefe,et al.  The western diet and lifestyle and diseases of civilization , 2011 .

[128]  A. Thompson,et al.  Non-soy legume consumption lowers cholesterol levels: a meta-analysis of randomized controlled trials. , 2011, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[129]  Jian-Min Yuan,et al.  Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study , 2011, Cancer Causes & Control.

[130]  Jaimie N. Davis,et al.  Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption. , 2010, The American journal of clinical nutrition.

[131]  R. Kreis,et al.  Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men. , 2010, Diabetes & metabolism.

[132]  J. Ntambi,et al.  Genetic control of de novo lipogenesis: role in diet-induced obesity , 2010, Critical reviews in biochemistry and molecular biology.

[133]  R. P. Ross,et al.  Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. , 2010, Nutrition reviews.

[134]  J. Hoofnagle,et al.  Increased caffeine consumption is associated with reduced hepatic fibrosis , 2010, Hepatology.

[135]  P. Hayes,et al.  Review article: omega‐3 fatty acids – a promising novel therapy for non‐alcoholic fatty liver disease , 2009, Alimentary pharmacology & therapeutics.

[136]  T. Trinidad,et al.  The potential health benefits of legumes as a good source of dietary fibre , 2009, British Journal of Nutrition.

[137]  R. Hayes,et al.  The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer , 2009, Aging cell.

[138]  S. Cuzzocrea,et al.  Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. , 2009, The Journal of nutrition.

[139]  R. Bibiloni,et al.  Impact of coffee consumption on the gut microbiota: a human volunteer study. , 2009, International journal of food microbiology.

[140]  M. Nakashima,et al.  Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: The significance of dietary cholesterol , 2009, Scandinavian journal of gastroenterology.

[141]  Xiong Ma,et al.  Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. , 2008, Journal of hepatology.

[142]  Alexander Pertsemlidis,et al.  Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease , 2008, Nature Genetics.

[143]  Rosanna Abbate,et al.  Adherence to Mediterranean diet and health status: meta-analysis , 2008, BMJ : British Medical Journal.

[144]  C. Datz,et al.  Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease. , 2008, Gastroenterology.

[145]  Nils Roos,et al.  Bioactive peptides and proteins from foods: indication for health effects , 2008, European journal of nutrition.

[146]  M. Kuskowski,et al.  A whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical study , 2008, Nutrition & metabolism.

[147]  P. Lundberg,et al.  Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects , 2008, Gut.

[148]  P. G. Reeves,et al.  Pinto bean consumption changes SCFA profiles in fecal fermentations, bacterial populations of the lower bowel, and lipid profiles in blood of humans. , 2007, The Journal of nutrition.

[149]  P. Turnbaugh,et al.  Microbial ecology: Human gut microbes associated with obesity , 2006, Nature.

[150]  A. Shenkin The key role of micronutrients. , 2006, Clinical nutrition.

[151]  J. Jessurun,et al.  Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[152]  Mark A Pereira,et al.  Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis , 2005, The Lancet.

[153]  G. Musso,et al.  Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis , 2003, Hepatology.

[154]  P. Lim,et al.  8-Iso-Prostaglandin F2α as a Useful Clinical Biomarker of Oxidative Stress in ESRD Patients , 2003, Blood Purification.

[155]  A. Simopoulos,et al.  The importance of the ratio of omega-6/omega-3 essential fatty acids. , 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[156]  Mark A Pereira,et al.  Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. , 2002, JAMA.

[157]  A. Klatsky,et al.  Alcohol, Smoking, Cofee, and Cirrhosis , 1992 .

[158]  M. Akhlaghi,et al.  Olive oil lessened fatty liver severity independent of cardiometabolic correction in patients with non-alcoholic fatty liver disease: A randomized clinical trial. , 2019, Nutrition.

[159]  J. Sherriff,et al.  Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes. , 2016, Advances in nutrition.

[160]  Bryan K. Smith,et al.  Statins and almonds to lower lipoproteins (the STALL Study). , 2015, Journal of clinical lipidology.

[161]  Shelly C. Lu,et al.  Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. , 2015, Gastroenterology.