Cause of death in patients attending multiple sclerosis clinics

Between 1972 and 1988, 145 deaths occurred among 3,126 patients attending the Multiple Sclerosis (MS) Clinics in Vancouver, British Columbia (N = 1,583), and London, Ontario (N = 1,543). We could determine the exact cause of death in 82.1% of cases (119 of 145). Of the 119 patients for whom the cause of death was known, 56 deaths (47.1%) were directly attributed to complications of MS. Of the remaining 63 deaths, 18 (28.6%) were suicides, 19 (30.2%) were due to malignancy, 13 (20.6%) to an acute myocardial infarction, seven (11.1%) to stroke, and the remainder (9.5%) to miscellaneous causes, of which two may have been suicides. The proportion of suicides among MS deaths was 7.5 times that for the age-matched general population, and the proportion of MS deaths from malignancy was 0.67 times that for the age-matched general population. The proportion of deaths due to malignancy and stroke was the same for the MS patients and the age-matched general population.

[1]  D. Goodkin.  The Natural History of Multiple Sclerosis , 1992 .

[2]  A. Filouš.  [Diagnosis of multiple sclerosis]. , 1989, Ceskoslovenska neurologie a neurochirurgie.

[3]  S. Lai,et al.  World-wide trends in multiple sclerosis mortality. , 1989, Neuroepidemiology.

[4]  J. Kurtzke,et al.  Survival in multiple sclerosis. , 1989, Journal of clinical epidemiology.

[5]  K. Wells,et al.  Psychiatric disorder in a sample of the general population with and without chronic medical conditions. , 1988, The American journal of psychiatry.

[6]  J. G. Phadke.  Survival pattern and cause of death in patients with multiple sclerosis: results from an epidemiological survey in north east Scotland. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[7]  R. Joffe,et al.  Mood disorder and multiple sclerosis. , 1987, Archives of neurology.

[8]  W. Honer,et al.  Temporal lobe involvement in multiple sclerosis patients with psychiatric disorders. , 1987, Archives of neurology.

[9]  G. Pearlson,et al.  Structural brain correlates of emotional disorder in multiple sclerosis. , 1986, Brain : a journal of neurology.

[10]  J. Fries,et al.  Survival, prognosis, and causes of death in rheumatoid arthritis. , 1986, Arthritis and rheumatism.

[11]  A. Sadovnick,et al.  Prevalence of Multiple Sclerosis in British Columbia , 1986, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[12]  J. Aarli,et al.  Multiple sclerosis and mortality statistics , 1985, Acta neurologica Scandinavica.

[13]  M. Reznikoff,et al.  Depression in multiple sclerosis as a function of length and severity of illness, age, remissions, and perceived social support. , 1984, Journal of clinical psychology.

[14]  J. Kurtzke.  Rating neurologic impairment in multiple sclerosis , 1983, Neurology.

[15]  H. Powell,et al.  Pathology of multiple sclerosis. , 1983, Neurologic clinics.

[16]  D. Silberberg,et al.  New diagnostic criteria for multiple sclerosis: Guidelines for research protocols , 1983, Annals of neurology.

[17]  V. Clark,et al.  Underlying cause of death as recorded for multiple sclerosis patients: associated factors. , 1983, Journal of chronic diseases.

[18]  S. Iversen.  Multiple sclerosis: mortality in Scotland 1974-80. , 1982, Journal of epidemiology and community health.

[19]  I. Allen,et al.  GENERAL DISEASE IN 120 NECROPSY‐PROVEN CASES OF MULTIPLE SCLEROSIS , 1978, Neuropathology and applied neurobiology.

[20]  E. Operskalski,et al.  Multiple sclerosis among Spanish‐surnamed Californians , 1978, Neurology.

[21]  S. Currie,et al.  Concurrence of multiple sclerosis and glioma , 1974, Journal of neurology, neurosurgery, and psychiatry.

[22]  I. Freiman,et al.  Multiple cerebral gliomas in multiple sclerosis , 1973, Journal of neurology, neurosurgery, and psychiatry.

[23]  H. Dassel.  THE MORTALITY FROM MULTIPLE SCLEROSIS IN THE NETHERLANDS , 1972, Nederlands tijdschrift voor geneeskunde.

[24]  G. Beebe,et al.  Studies on the natural history of multiple sclerosis. V. Long-term survival in young men. , 1970, Archives of neurology.

[25]  L. Kurland,et al.  Multiple sclerosis in Rochester, Minnesota--a 60-year appraisal. , 1968, Transactions of the American Neurological Association.

[26]  F. Mcdowell,et al.  PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS , 1965, Annals of the New York Academy of Sciences.

[27]  L. Kurland,et al.  MULTIPLE SCLEROSIS IN WINNIPEG, MANITOBA: METHODOLOGICAL CONSIDERATIONS OF EPIDEMIOLOGIC SURVEY. TEN YEAR FOLLOW-UP OF A COMMUNITY WIDE STUDY, AND POPULATION RE-SURVEY. , 1964, Journal of chronic diseases.