Cerebellar role in Parkinson's disease.

Parkinson's disease (PD) is a common neurodegenerative disorder associated with motor and cognitive impairments. The mechanisms underlying the pathophysiology and treatments have traditionally focused on basal ganglia-thalamo-cortical pathways due to striatal dopamine loss, but more recent evidence has highlighted the role of the cerebellum. In this Neuro Forum article, I review evidence from neuroimaging and noninvasive brain stimulation that demonstrates altered cerebellar activity in PD may be both a pathophysiological and compensatory mechanism depending on dopaminergic medication and symptoms.

[1]  M. Hallett.  Transcranial Magnetic Stimulation: A Primer , 2007, Neuron.

[2]  M. Hallett,et al.  The cerebellum in Parkinson’s disease , 2013, Brain : a journal of neurology.

[3]  Andreea C. Bostan,et al.  Cerebellar networks with the cerebral cortex and basal ganglia , 2013, Trends in Cognitive Sciences.

[4]  L. Timmermann,et al.  A systematic review on the applications of resting-state fMRI in Parkinson's disease: Does dopamine replacement therapy play a role? , 2015, Cortex.

[5]  Fei Wang,et al.  Altered resting-state functional connectivity of the dentate nucleus in Parkinson's disease , 2013, Psychiatry Research: Neuroimaging.

[6]  Sara B. Festini,et al.  Altered cerebellar connectivity in Parkinson's patients ON and OFF L-DOPA medication , 2015, Front. Hum. Neurosci..

[7]  A. Berardelli,et al.  Does the cerebellum intervene in the abnormal somatosensory temporal discrimination in Parkinson's disease? , 2015, Parkinsonism & related disorders.

[8]  Alvaro Pascual-Leone,et al.  Intermittent Theta-Burst Stimulation of the Lateral Cerebellum Increases Functional Connectivity of the Default Network , 2014, The Journal of Neuroscience.

[9]  H. Johansen-Berg,et al.  Distinct and overlapping functional zones in the cerebellum defined by resting state functional connectivity. , 2010, Cerebral cortex.

[10]  G. Koch,et al.  Study of Cerebello-Thalamocortical Pathway by Transcranial Magnetic Stimulation in Parkinson's Disease , 2013, Brain Stimulation.

[11]  A. Berardelli,et al.  Effects of cerebellar continuous theta burst stimulation on resting tremor in Parkinson's disease. , 2015, Parkinsonism & related disorders.

[12]  J. Jankovic.  Parkinson’s disease: clinical features and diagnosis , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[13]  C. Caltagirone,et al.  Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease , 2009, Neurology.

[14]  M. Hallett,et al.  Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? , 2012, Brain : a journal of neurology.