Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis

Poorly differentiated thyroid carcinomas (PDTC) occupy an intermediate position at the prognostic level on the spectrum of thyroid carcinoma progression. However, their histologic definition is controversial. The objective of the current study was to assess the prognostic significance of PDTC defined on the basis of mitosis and necrosis and search for prognostic markers within this group of tumors that are predictive of overall survival (OS) and progression‐free survival (PFS).

[1]  M. Papotti,et al.  Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns , 2004, Cancer.

[2]  S. Cushing,et al.  Prognostic Factors in Well‐Differentiated Thyroid Carcinoma , 2004, The Laryngoscope.

[3]  J. Rosai,et al.  Poorly differentiated (“insular”) thyroid carcinoma: A reinterpretation of Langhans' “wuchernde Struma” , 1984, The American journal of surgical pathology.

[4]  T. Nishida,et al.  Clinicopathological significance of poorly differentiated thyroid carcinoma. , 1999, The American journal of surgical pathology.

[5]  M. Papotti,et al.  Papillary and follicular thyroid carcinomas with an insular component , 1994, Cancer.

[6]  A. F. Stewart,et al.  Poorly differentiated ("insular") carcinoma of the thyroid gland: an aggressive subset of differentiated thyroid neoplasms. , 1988, Surgery.

[7]  Y. Suh,et al.  Oncocytic adrenocortical carcinomas: A pathological and immunohistochemical study of four cases in comparison with conventional adrenocortical carcinomas , 2004, Pathology international.

[8]  F. Rilke,et al.  Poorly differentiated forms of papillary thyroid carcinoma: distinctive entities or morphological patterns? , 1995, Seminars in diagnostic pathology.

[9]  M. Sobrinho-Simões.  Poorly differentiated carcinomas of the thyroid , 1996 .

[10]  M. Nikiforova,et al.  Solid Variant of Papillary Thyroid Carcinoma: Incidence, Clinical–Pathologic Characteristics, Molecular Analysis, and Biologic Behavior , 2001, The American journal of surgical pathology.

[11]  J. Rosai.  Poorly differentiated thyroid carcinoma: Introduction to the issue, its landmarks, and clinical impact , 2004, Endocrine pathology.

[12]  L. Akslen,et al.  Poorly differentiated thyroid carcinoma--it is important. , 2000, The American journal of surgical pathology.

[13]  W. Lehman.  Tumors of the thyroid gland. , 1950, Northwest medicine.

[14]  D. Hawes,et al.  Insular carcinoma: a distinct thyroid carcinoma with associated iodine-131 localization. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[15]  L. Akslen,et al.  Prognostic significance of histologic grading compared with subclassification of papillary thyroid carcinoma , 2000, Cancer.

[16]  B. Wenig.  Prognostic significance of insular component in thyroid carcinoma , 2003 .

[17]  R. Nishiyama.  Another dissertation on poorly differentiated carcinomas: is it really necessary? , 1999, Advances in anatomic pathology.

[18]  A. Sakamoto,et al.  Poorly differentiated carcinoma of the thyroid. A clinicopathologic entity for a high‐risk group of papillary and follicular carcinomas , 1983, Cancer.

[19]  A. Sakamoto.  Definition of poorly differentiated carcinoma of the thyroid: The Japanese experience , 2004, Endocrine pathology.

[20]  M. Papotti,et al.  Poorly Differentiated Thyroid Carcinomas with Primordial Cell Component: A Group of Aggressive Lesions Sharing Insular, Trabecular,and Solid Patterns , 1993, The American journal of surgical pathology.