Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS)
暂无分享,去创建一个
[1] Jong Min Lee,et al. Application of chemical reaction engineering principles to 'body-on-a-chip' systems. , 2018, AIChE journal. American Institute of Chemical Engineers.
[2] Michael L Shuler,et al. Design and demonstration of a pumpless 14 compartment microphysiological system , 2016, Biotechnology and bioengineering.
[3] Yordan Kostov,et al. The Design and Fabrication of Three‐Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors , 2008, Biotechnology progress.
[4] M. Shuler,et al. Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening , 2017, Biotechnology and bioengineering.
[5] Claudio Domenici,et al. Metabolic control through hepatocyte and adipose tissue cross-talk in a multicompartmental modular bioreactor. , 2011, Tissue engineering. Part A.
[6] Uwe Marx,et al. A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing. , 2015, Journal of biotechnology.
[7] William McLamb,et al. Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs , 2016, Scientific Reports.
[8] Jong Hwan Sung,et al. 3D gut-liver chip with a PK model for prediction of first-pass metabolism , 2017, Biomedical microdevices.
[9] Tim Morris,et al. Physiological Parameters in Laboratory Animals and Humans , 1993, Pharmaceutical Research.
[10] Jong Hwan Sung,et al. A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. , 2010, Lab on a chip.
[11] Mandy B. Esch,et al. Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue. , 2016, Lab on a chip.
[12] DA Lauffenburger,et al. Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems , 2015, CPT: pharmacometrics & systems pharmacology.
[13] V. Novelli,et al. A novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia , 2017, PloS one.
[14] Hanry Yu,et al. Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. , 2009, Lab on a chip.
[15] F. Sonntag,et al. A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. , 2013, Lab on a chip.
[16] Arti Ahluwalia,et al. Allometric Scaling and Cell Ratios in Multi-Organ in vitro Models of Human Metabolism , 2014, Front. Bioeng. Biotechnol..
[17] F. Sonntag,et al. A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents. , 2015, Lab on a chip.
[18] Pierre Baldi,et al. Deep Learning for Drug Discovery and Cancer Research: Automated Analysis of Vascularization Images , 2019, IEEE/ACM Transactions on Computational Biology and Bioinformatics.
[19] Steven W. Martin,et al. The role of mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modelling in translational research of biologics. , 2007, Drug discovery today.
[20] Lucas H. Hofmeister,et al. Scaling and systems biology for integrating multiple organs-on-a-chip. , 2013, Lab on a chip.
[21] João Ribas,et al. Microphysiological systems: analysis of the current status, challenges and commercial future , 2018 .
[22] Andreas Hierlemann,et al. Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis , 2014, Nature Communications.
[23] Eric Leclerc,et al. Investigation of omeprazole and phenacetin first‐pass metabolism in humans using a microscale bioreactor and pharmacokinetic models , 2015, Biopharmaceutics & drug disposition.
[24] Yasuyuki Sakai,et al. Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system. , 2011, Toxicology letters.
[25] James J Hickman,et al. Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers. , 2017, Biomaterials.
[26] Jong Hwan Sung,et al. Recent Advances in Body-on-a-Chip Systems. , 2018, Analytical chemistry.
[27] A. Ahluwalia,et al. A low shear stress modular bioreactor for connected cell culture under high flow rates , 2010, Biotechnology and bioengineering.
[28] Ning Hu,et al. Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors , 2017, Proceedings of the National Academy of Sciences.
[29] Federico Vozzi,et al. Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor. , 2009, Tissue engineering. Part A.
[30] Aaron Sin,et al. Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity , 2008, Biotechnology progress.
[31] Anne Riu,et al. Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. , 2018, Biomaterials.
[32] Arti Ahluwalia,et al. An in vitro model of glucose and lipid metabolism in a multicompartmental bioreactor , 2012, Biotechnology journal.
[33] Murat Cirit,et al. Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS). , 2017, Integrative biology : quantitative biosciences from nano to macro.
[34] Christopher Moraes,et al. On being the right size: scaling effects in designing a human-on-a-chip. , 2013, Integrative biology : quantitative biosciences from nano to macro.
[35] Tai Hyun Park,et al. Microtechnology‐based organ systems and whole‐body models for drug screening , 2016, Biotechnology journal.
[36] Jong Hwan Sung,et al. Robust parameter estimation for physiologically based pharmacokinetic model of Tegafur with dissolution dynamics , 2015 .
[37] DA Lauffenburger,et al. Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration , 2015, CPT: pharmacometrics & systems pharmacology.
[38] Michael L Shuler,et al. UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems. , 2018, Lab on a chip.
[39] Jong Hwan Sung,et al. Organ‐on‐a‐Chip Technology for Reproducing Multiorgan Physiology , 2018, Advanced healthcare materials.
[40] Uwe Marx,et al. Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure. , 2010, Journal of biotechnology.
[41] J T Borenstein,et al. A multiplexed microfluidic system for evaluation of dynamics of immune-tumor interactions. , 2018, Lab on a chip.
[42] Jong Hwan Sung,et al. A pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model , 2017, Biotechnology and bioengineering.
[43] M KLEIBER,et al. Body size, growth rate and metabolic rate in two inbred strains of rats. , 1950, The American journal of physiology.
[44] Michael L Shuler,et al. Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. , 2015, Integrative biology : quantitative biosciences from nano to macro.
[45] Uwe Marx,et al. The ascendance of microphysiological systems to solve the drug testing dilemma , 2017, Future science OA.
[46] James H. Brown,et al. A General Model for the Origin of Allometric Scaling Laws in Biology , 1997, Science.
[47] Michael L Shuler,et al. A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers , 2009, Biotechnology and bioengineering.
[48] Eric Leclerc,et al. First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans , 2014, Biotechnology and bioengineering.
[49] James H Brown,et al. Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[50] Uwe Marx,et al. Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[51] Michael L Shuler,et al. Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges , 2018, Advanced healthcare materials.
[52] O. Snell. Die Abhängigkeit des Hirngewichtes von dem Körpergewicht und den geistigen Fähigkeiten , 1892, Archiv für Psychiatrie und Nervenkrankheiten.
[53] Arti Ahluwalia,et al. Engineering Quasi-Vivo in vitro organ models. , 2012, Advances in experimental medicine and biology.