Intercellular adhesion molecule-1 gene polymorphisms in Behçet's disease.

Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease. The expression of both soluble and tissue ICAM-1 is increased in Behçet's disease (BD) but the contribution of ICAM-1 gene polymorphisms to this disease remains unknown. Associations with BD have been reported for genes within the MHC, including HLA-B51, TNF and MICA, but the role of non-MHC genes in BD remains largely unexplored. We have investigated the frequency of the R/G 241 and K/E 469 ICAM-1 gene polymorphisms in 83 patients with BD disease and 103 healthy controls, all of Palestinian and Jordanian descent, and demonstrated an association between BD and the ICAM-1 E469 allele (Pc = 0.046, OR = 2.1). Among patients, no association was found between the presence of ocular disease and ICAM-1 polymorphisms. While the functional correlate of this polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain, which is independent of the MHC, may contribute to disease.

[1]  E. Donadi,et al.  Association of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds. , 2001, Thyroid : official journal of the American Thyroid Association.

[2]  M. Hüfner,et al.  Disseminated thyroid autonomy or Graves' disease: reevaluation by a second generation TSH receptor antibody assay. , 2000, Thyroid : official journal of the American Thyroid Association.

[3]  N. Nakamura,et al.  Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. , 2000, Human immunology.

[4]  R. Vaughan,et al.  HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behçet's disease. , 1999, Tissue antigens.

[5]  R. Vaughan,et al.  Factor V Leiden mutation is associated with ocular involvement in Behçet disease. , 1999, American journal of ophthalmology.

[6]  S. Fuggle,et al.  Adhesion molecule polymorphisms in chronic renal allograft failure. , 1999, Kidney international.

[7]  K. Selmaj,et al.  Multiple sclerosis: The increased frequency of the ICAM‐1 exon 6 gene point mutation genetic type K469 , 1998, Annals of neurology.

[8]  P. Seed,et al.  Soluble adhesion molecules in Behçet's disease. , 1998, Ocular immunology and inflammation.

[9]  R. Nussenblatt,et al.  Ocular immunopathology of Behçet's disease. , 1997, Survey of ophthalmology.

[10]  M. Inanç,et al.  Coagulation factor V gene mutation increases the risk of venous thrombosis in behçet's disease. , 1996, British journal of rheumatology.

[11]  M. Nishikawa,et al.  Expression of intercellular adhesion molecule-1 on human thyroid cells from patients with autoimmune thyroid disease: study of thyroid xenografts in nude and severe combined immunodeficient mice and treatment with FK-506. , 1995, The Journal of clinical endocrinology and metabolism.

[12]  K. Mori,et al.  Intercellular adhesion molecule-1 (ICAM-1) in the sera of patients with Graves' disease: correlation with disease activity and treatment status. , 1995, Thyroid : official journal of the American Thyroid Association.

[13]  A. Beaudet,et al.  Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease. , 1995, Gastroenterology.

[14]  P. Biberfeld,et al.  Immunohistology of skin pathergy reaction in Behçet's disease , 1995, The British journal of dermatology.

[15]  A. Beaudet,et al.  Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster. , 1994, Genomics.

[16]  J. Johnson,et al.  Domain 5 of the intercellular adhesion molecule-1 (ICAM-1) is involved in adhesion of B-cells and follicular dendritic cells. , 1994, Advances in experimental medicine and biology.

[17]  Timothy A. Springer,et al.  Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation , 1991, Cell.

[18]  Shirley A. Miller,et al.  A simple salting out procedure for extracting DNA from human nucleated cells. , 1988, Nucleic acids research.

[19]  A. Silman,et al.  [Criteria of diagnosis of Behcet's disease]. , 1975, La Tunisie medicale.