Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism

Objectives It has been reported that the non‐renal clearance of furosemide was significantly faster in rats pretreated with phenobarbital but was not altered in rats pretreated with 3‐methylcholanthrene. However, no studies on other cytochrome P450 (CYP) isozymes have yet been reported in rats.

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