Development of a Surface Plasmon Resonance-Based Biosensing System

Surface Plasmon Resonance (SPR)-based biosensing systems have become very popular among biologists and biochemists due to their ability to sense biomolecular interaction kinetics. It can be easily surmised that such systems may be of great use in diagnostic applications as well. However, the principal impediment to wide-scale deployment of these devices is the cost of the instrument. This effort to develop a low cost, widely deployable instrument was born out of a desire to initially popularize this instrument and technique among colleges and universities with budget constraints and move toward developing diagnostic applications on this platform. A low-cost device with significant sensitivity was developed, and this chapter describes the development on this front.

[1]  J. Homola.  Present and future of surface plasmon resonance biosensors , 2003, Analytical and bioanalytical chemistry.

[2]  B. Liedberg,et al.  Surface plasmon resonance for gas detection and biosensing , 1983 .

[3]  A. Otto.  Excitation of nonradiative surface plasma waves in silver by the method of frustrated total reflection , 1968 .

[4]  Antonio Marcus Nogueira Lima,et al.  Optical properties and instrumental performance of thin gold films near the surface plasmon resonance , 2006 .

[5]  J. Homola.  On the sensitivity of surface plasmon resonance sensors with spectral interrogation , 1997 .

[6]  Günter Gauglitz,et al.  Surface plasmon resonance sensors: review , 1999 .

[7]  Nicole Jaffrezic-Renault,et al.  Surface plasmon resonance fibre-optic sensor for gas detection , 1997 .

[8]  R. Wood.  XLII. On a remarkable case of uneven distribution of light in a diffraction grating spectrum , 1902 .

[9]  Gerald Urban,et al.  Springer series on chemical sensors and biosensors : methods and applications , 2004 .

[10]  C. Thirstrup,et al.  Data analysis for surface plasmon resonance sensors using dynamic baseline algorithm , 2005 .

[11]  Xiaocong Yuan,et al.  Optimised film thickness for maximum evanescent field enhancement of a bimetallic film surface plasmon resonance biosensor , 2006 .

[12]  R. Wood,et al.  On a Remarkable Case of Uneven Distribution of Light in a Diffraction Grating Spectrum , 1902 .

[13]  Andrew Wilkinson.  Compendium of Chemical Terminology , 1997 .

[14]  E. Kretschmann,et al.  Notizen: Radiative Decay of Non Radiative Surface Plasmons Excited by Light , 1968 .

[15]  Daniel Poitras,et al.  Local similarity matching algorithm for determining SPR angle in surface plasmon resonance sensors , 2007 .