Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

[1]  Alexey Sergushichev,et al.  Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. , 2015, Molecular cell.

[2]  J. Engelman,et al.  Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer. , 2015, Cancer cell.

[3]  J. Albeck,et al.  Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton , 2014, Cancer & Metabolism.

[4]  A. Koromilas,et al.  Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α* , 2014, The Journal of Biological Chemistry.

[5]  A. Harris,et al.  PCK2 activation mediates an adaptive response to glucose depletion in lung cancer , 2014, Oncogene.

[6]  S. Gabriel,et al.  Discovery and saturation analysis of cancer genes across 21 tumor types , 2014, Nature.

[7]  Yujun Hao,et al.  Targeting the Protein–Protein Interaction between IRS1 and Mutant p110α for Cancer Therapy , 2014, Toxicologic pathology.

[8]  L. Cantley,et al.  What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. , 2013, Cancer discovery.

[9]  Ralph J DeBerardinis,et al.  Glutamine and cancer: cell biology, physiology, and clinical opportunities. , 2013, The Journal of clinical investigation.

[10]  S. Markowitz,et al.  Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions. , 2013, Cancer cell.

[11]  Gregory Stephanopoulos,et al.  The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 , 2013, Cell.

[12]  G. Stephanopoulos,et al.  In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. , 2013, Cell metabolism.

[13]  John M. Asara,et al.  Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.

[14]  A. Lane,et al.  Control of Glutamine Metabolism By the Tumor Suppressor Rb , 2013, Oncogene.

[15]  K. Wellen,et al.  Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence , 2012, Nature.

[16]  J. Maris,et al.  ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. , 2012, Cancer cell.

[17]  Chi V Dang,et al.  Links between metabolism and cancer. , 2012, Genes & development.

[18]  John E. Burke,et al.  Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases , 2011, Science Signaling.

[19]  Colin N. Dewey,et al.  RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome , 2011, BMC Bioinformatics.

[20]  Julian Downward,et al.  RAS Interaction with PI3K: More Than Just Another Effector Pathway. , 2011, Genes & cancer.

[21]  Yiqing Zhao,et al.  DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination , 2010, Science Signaling.

[22]  R. Abraham,et al.  A metabolic (re-)balancing act. , 2010, Molecules and Cells.

[23]  W. Wheaton,et al.  Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity , 2010, Proceedings of the National Academy of Sciences.

[24]  S. Sugano,et al.  Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species , 2010, Proceedings of the National Academy of Sciences.

[25]  Kishore Guda,et al.  Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T , 2010, Proceedings of the National Academy of Sciences.

[26]  K. Kinzler,et al.  Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation , 2010, Proceedings of the National Academy of Sciences.

[27]  K. Kinzler,et al.  Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells , 2009, Science.

[28]  Jeffrey A. Engelman,et al.  Targeting PI3K signalling in cancer: opportunities, challenges and limitations , 2009, Nature Reviews Cancer.

[29]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[30]  A. Lane,et al.  Targeting aspartate aminotransferase in breast cancer , 2008, Breast Cancer Research.

[31]  L. Zhao,et al.  Class I PI3K in oncogenic cellular transformation , 2008, Oncogene.

[32]  Z. Weng,et al.  Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies , 2008, Nature Methods.

[33]  A. Sparks,et al.  The Genomic Landscapes of Human Breast and Colorectal Cancers , 2007, Science.

[34]  U. Andersson,et al.  Isoforms of alanine aminotransferases in human tissues and serum--differential tissue expression using novel antibodies. , 2007, Archives of biochemistry and biophysics.

[35]  A. Bardelli,et al.  Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers. , 2007, Cancer research.

[36]  C. Kahn,et al.  Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. , 2006, Cell metabolism.

[37]  Carlo Rago,et al.  Mutant PIK3CA promotes cell growth and invasion of human cancer cells. , 2005, Cancer cell.

[38]  P. Sassone-Corsi,et al.  ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology Implication for Coffin-Lowry Syndrome , 2004, Cell.

[39]  J. Ptak,et al.  High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.

[40]  R. DePinho,et al.  Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. , 2004, Cancer cell.

[41]  Maria Deak,et al.  A phosphoserine/threonine‐binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation , 2002, The EMBO journal.

[42]  Lewis C Cantley,et al.  The phosphoinositide 3-kinase pathway. , 2002, Science.

[43]  Ji Huang,et al.  [Serial analysis of gene expression]. , 2002, Yi chuan = Hereditas.

[44]  Tsung-Cheng Chang,et al.  c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2009, Nature.

[45]  Carlo Rago,et al.  Mutant PIK 3 CA promotes cell growth and invasion of human cancer cells , 2005 .