Simulation Modeling of Anthrax Spore Dispersion in a Bioterrorism Incident

Recent events have increased awareness of the risk posed by terrorist attacks. Bacillus anthracis has resurfaced in the 21st century as a deadly agent of bioterrorism because of its potential for causing massive civilian casualties. This analysis presents the results of a computer simulation of the dispersion of anthrax spores in a typical 50-story, high-rise building after an intentional release during a bioterrorist incident. The model simulates aerosol dispersion in the case of intensive, small-scale convection, which equalizes the concentration of anthrax spores over the building volume. The model can be used to predict the time interval required for spore dispersion throughout a building after a terrorist attack in a high-rise building. The analysis reveals that an aerosol release of even a relatively small volume of anthrax spores during a terrorist incident has the potential to quickly distribute concentrations that are infectious throughout the building.

[1]  M. Bronze,et al.  Bacterial Pathogens as Biological Weapons and Agents of Bioterrorism , 2002, The American journal of the medical sciences.

[2]  L. Baillie,et al.  The development of new vaccines against Bacillus anthracis , 2001, Journal of applied microbiology.

[3]  G. Stotzky,et al.  Effects of ozone on the germination of fungus spores. , 1969, Canadian journal of microbiology.

[4]  T. Read,et al.  Bacillus anthracis, a bug with attitude! , 2001, Current opinion in microbiology.

[5]  Steven M. Block,et al.  The Growing Threat of Biological Weapons , 2001, American Scientist.

[6]  Anthony S. Fauci,et al.  Bioterrorism: A clear and present danger , 2001, Nature Medicine.

[7]  M. Meltzer,et al.  The economic impact of a bioterrorist attack: are prevention and postattack intervention programs justifiable? , 1997, Emerging infectious diseases.

[8]  R. Millikan The General Law of Fall of a Small Spherical Body through a Gas, and its Bearing upon the Nature of Molecular Reflection from Surfaces , 1923 .

[9]  C. Haas Conditional Dose‐Response Relationships for Microorganisms: Development and Application , 2002, Risk analysis : an official publication of the Society for Risk Analysis.

[10]  Paulette Middleton,et al.  A kinetic aerosol model for the formation and growth of secondary sulfuric acid particles , 1978 .

[11]  D. Acosta,et al.  On the role of macrophages in anthrax. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[12]  John A. Young,et al.  Identification of the cellular receptor for anthrax toxin , 2001, Nature.

[13]  Eliot Marshall,et al.  New Anthrax Vaccine Gets a Green Light , 2002, Science.

[14]  K. Klimpel,et al.  Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity , 1994, Molecular microbiology.

[15]  P. Hanna,et al.  Understanding Bacillus anthracis pathogenesis. , 1999, Trends in microbiology.

[16]  Howard Reiss,et al.  The Kinetics of Phase Transitions in Binary Systems , 1950 .

[17]  Philip K. Russell,et al.  Anthrax as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. , 1999, JAMA.

[18]  C. P. Quinn,et al.  Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States. , 2001, Emerging infectious diseases.

[19]  T J Cieslak,et al.  Biological warfare : A historical perspective , 1997 .

[20]  Vladimir P Reshetin,et al.  Estimating receptor sensitivity to spatial proximity of emissions sources , 2002, Environmental science and pollution research international.

[21]  Julian Heicklen,et al.  Kinetics of particle growth. II. Kinetics of the reaction of ammonia with hydrogen chloride and the growth of pariculate ammonium chloride , 1973 .

[22]  T. Raffin,et al.  Inhalational anthrax: epidemiology, diagnosis, and management. , 1999, Chest.

[23]  M. Caporaloni,et al.  Transfer of Particles in Nonisotropic Air Turbulence , 1975 .