Mechanisms of the clasp-knife reflex studied in an animal model

SummaryThe mechanisms of the clasp-knife reflex were studied in the soleus muscle of an animal model, the decerebrate cat with a dorsal hemisection of the lower thoracic cord. The reflex is shown to be autogenetic, and to depend on muscle length in keeping with previous suggestions. However, the magnitude of the inhibition increases with increasing initial force, and the inhibition is mimicked by gentle manipulation of the muscle and tendon surface. Concurrent muscle afferent recordings showed that the electromyogram (emg) reduction was not a result of a decline in Ia afferent input and was not well related to secondary or tendon organ afferent discharge.It is now known that many group III and some group IV muscle afferents are also activated by muscle stretch and contraction, and we here report limited stretch sensitivity in four non-spindle group II afferents. Since these fiber groups each include afferents that produce inhibition of extensor motoneurons, it is proposed that the clasp-knife reflex may result from the activation of these slowly conducting afferent fibers.

[1]  P. Matthews,et al.  The relative sensitivity to vibration of muscle receptors of the cat , 1967, The Journal of physiology.

[2]  L. Jami.  [Functional properties of the Golgi tendon organs]. , 1988, Archives internationales de physiologie et de biochimie.

[3]  R. Granit,et al.  Supraspinal control of the muscle spindles and its significance , 1953, The Journal of physiology.

[4]  I. Engberg,et al.  Reticulospinal inhibition of transmission in reflex pathways , 1968, The Journal of physiology.

[5]  C. Hunt,et al.  RELATION OF FUNCTION TO DIAMETER IN AFFERENT FIBERS OF MUSCLE NERVES , 1954, The Journal of general physiology.

[6]  R. Eccles,et al.  Synaptic actions in motoneurones by afferents in which may evoke the flexion reflex , 1959 .

[7]  M. McGlamery.  Mammalian Muscle Receptors and Their Central Actions , 1973 .

[8]  G. C. Joyce,et al.  The mechanical properties of cat soleus muscle during controlled lengthening and shortening movements , 1969, The Journal of physiology.

[9]  J. Paillard,et al.  Autogenetic reflex effects of slow or steady stretch of the calf muscles in man , 2004, Experimental Brain Research.

[10]  John F. Fulton,et al.  Observations on Spinal and Decerebrate Knee-Jerks, with Special Reference to their Inhibition by Single Break-Shocks , 1925 .

[11]  B. Holmqvist,et al.  Differential supraspinal control of synaptic actions evoked by volleys in the flexion reflex afferents in alpha motoneurones. , 1961, Acta physiologica Scandinavica. Supplementum.

[12]  D. P. Lloyd.  REFLEX ACTION IN RELATION TO PATTERN AND PERIPHERAL SOURCE OF AFFERENT STIMULATION , 1943 .

[13]  R. Herman,et al.  The myotatic reflex. Clinico-physiological aspects of spasticity and contracture. , 1970, Brain : a journal of neurology.

[14]  D Burke,et al.  The quadriceps stretch reflex in human spasticity. , 1970, Journal of neurology, neurosurgery, and psychiatry.

[15]  A. Lundberg,et al.  Comments on reflex actions evoked by electrical stimulation of group II muscle afferents , 1977, Brain Research.

[16]  P. Ellaway,et al.  Autogenetic reflex action on to gamma motoneurones by stretch of triceps surae in the decerebrated cat. , 1978, The Journal of physiology.

[17]  P. Matthews.  The dependence of tension upon extension in the stretch reflex of the soleus muscle of the decerebrate cat , 1959, The Journal of physiology.

[18]  T. Sears,et al.  Monosynaptic excitation of motoneurones from secondary endings of muscle spindles , 1974, Nature.

[19]  D. Westbury,et al.  A study of stretch and vibration reflexes of the cat by intracellular recording from motoneurones , 1972, The Journal of physiology.

[20]  Inhibition of knee jerk from tendon spindles of crureus. , 1950, Journal of neurophysiology.

[21]  P. Bessou,et al.  E'tude des rècepteurs musculaires innervès par les fibres affèrentes du groupe III ( fibres myelinisèes fines ), chez le chat , 1961 .

[22]  S. W. Kuffler,et al.  Stretch receptor discharges during muscle contraction , 1951, The Journal of physiology.

[23]  R. Schmidt,et al.  MECHANISMS OF MUSCLE PAIN: A COMPARISON WITH CUTANEOUS NOCICEPTION , 1976 .

[24]  R. Reinking,et al.  Analysis of muscle receptor connections by spike-triggered averaging. 2. Spindle group II afferents. , 1976, Journal of neurophysiology.

[25]  E. Perl,et al.  Alteration of spinal reflexes by interaction with suprasegmental and dorsal root activity , 1960, The Journal of physiology.

[26]  S Grillner,et al.  Is the tonic stretch reflex dependent upon group II excitation? , 1970, Acta physiologica Scandinavica.

[27]  D. Burke,et al.  autogenic effects of static muscle stretch in spastic man. , 1971, Archives of neurology.

[28]  J. Houk,et al.  Adequate stimulus for tendon organs with observations on mechanics of ankle joint. , 1971, Journal of neurophysiology.

[29]  C. Fromm,et al.  Length-dependent autogenetic inhibition of extensor γ-motoneurones in the decerebrate cat , 2004, Pflügers Archiv.

[30]  P. Matthews,et al.  Evidence from the use of vibration during procaine nerve block that the spindle group II fibres contribute excitation to the tonic stretch reflex of the decerebrate cat , 1973, The Journal of physiology.

[31]  A. Cangiano,et al.  The action of selectively activated group II muscle afferent fibers on extensor motoneurons. , 1972, Brain research.

[32]  Steen Andreassen,et al.  Interval pattern of single motor units , 1978 .

[33]  J. Jansen,et al.  ON THE SILENT PERIOD AND GOLGI TENDON ORGANS OF THE SOLEUS MUSCLE OF THE CAT. , 1964, Acta physiologica Scandinavica.

[34]  S. Grillner,et al.  Motor unit activity and stiffness of the contracting muscle fibres in the tonic stretch reflex. , 1971, Acta physiologica Scandinavica.

[35]  P. Matthews.  Evidence that the secondary as well as the primary endings of the muscle spindles may be responsible for the tonic stretch reflex of the decerebrate cat , 1969, The Journal of physiology.

[36]  S. Mense,et al.  Muscle receptors with group IV afferent fibres responding to application of bradykinin , 1975, Brain Research.

[37]  J. Houk,et al.  Responses of Golgi tendon organs to active contractions of the soleus muscle of the cat. , 1967, Journal of neurophysiology.

[38]  W. Rymer,et al.  An estimate of the secondary spindle receptor afferent contribution to the stretch reflex in extensor muscles of the decerebrate cat. , 1977, The Journal of physiology.

[39]  A. Paintal,et al.  Functional analysis of Group III afferent fibres of mammalian muscles , 1960, The Journal of physiology.

[40]  D Burke,et al.  Spasticity, decerebrate rigidity and the clasp-knife phenomenon: an experimental study in the cat. , 1972, Brain : a journal of neurology.

[41]  B. Matthews.  Nerve endings in mammalian muscle , 1933, The Journal of physiology.

[42]  Stacey Mj.  Free nerve endings in skeletal muscle of the cat. , 1969 .

[43]  J. Fulton,et al.  A NOTE CONCERNING THE PROBABLE FUNCTION OF VARIOUS AFFERENT END-ORGANS IN SKELETAL MUSCLE , 1928 .

[44]  J. Eccles,et al.  Experimental investigations on the afferent fibres in muscle nerves , 1951, Proceedings of the Royal Society of London. Series B - Biological Sciences.