A plasmonic biosensor array by block copolymer lithography

Highly uniform and dense, hexagonal noble metal nanoparticle arrays were achieved on large-area transparent glass substrates via scalable, parallel processing of block copolymer lithography. Exploring their localized surface plasmon resonance (LSPR) characteristics revealed that the Ag nanoparticle array displayed a UV-vis absorbance spectrum sufficiently narrow and intense for biosensing application. A highly-sensitive, label-free detection of prostate cancer specific antibody (anti-PSA) with sub-ng ml−1 level detection limit (0.1∼1 ng ml−1) has been accomplished with the plasmonic nanostructure. Our approach offers a valuable route to a low-cost, manufacture-scale production of plasmonic nanostructures, potentially useful for various photonic and optoelectronic devices.

[1]  Sang Ouk Kim,et al.  Highly efficient vertical growth of wall-number-selected, N-doped carbon nanotube arrays. , 2009, Nano letters.

[2]  Sarah Kim,et al.  Localized surface plasmon resonance (LSPR) sensitivity of Au nanodot patterns to probe solvation effects in polyelectrolyte brushes. , 2008, Chemical communications.

[3]  Masato Saito,et al.  Label-free detection of melittin binding to a membrane using electrochemical-localized surface plasmon resonance. , 2008, Analytical chemistry.

[4]  W. Barnes,et al.  Surface plasmon subwavelength optics , 2003, Nature.

[5]  Sang-Won Kang,et al.  Universal Block Copolymer Lithography for Metals, Semiconductors, Ceramics, and Polymers , 2008 .

[6]  Steven R. Emory,et al.  Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering , 1997, Science.

[7]  R. V. Van Duyne,et al.  Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor. , 2005, Journal of the American Chemical Society.

[8]  Ting Xu,et al.  The influence of molecular weight on nanoporous polymer films , 2001 .

[9]  P. Nealey,et al.  Epitaxial self-assembly of block copolymers on lithographically defined nanopatterned substrates , 2003, Nature.

[10]  J. Storhoff,et al.  Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. , 1997, Science.

[11]  K. Guarini,et al.  Ultrahigh-density nanowire arrays grown in self-assembled diblock copolymer templates. , 2000, Science.

[12]  J. Krenn,et al.  Watching energy transfer , 2003, Nature materials.

[13]  Harry A. Atwater,et al.  Local detection of electromagnetic energy transport below the diffraction limit in metal nanoparticle plasmon waveguides , 2003, Nature materials.

[14]  M. Ratner,et al.  Multipolar excitation in triangular nanoprisms. , 2005, The Journal of chemical physics.

[15]  Ulrich S Schubert,et al.  Nanolithography and nanochemistry: probe-related patterning techniques and chemical modification for nanometer-sized devices. , 2004, Angewandte Chemie.

[16]  Bong Hoon Kim,et al.  Soft graphoepitaxy of block copolymer assembly with disposable photoresist confinement. , 2009, Nano letters.

[17]  C. Hawker,et al.  Controlling Polymer-Surface Interactions with Random Copolymer Brushes , 1997, Science.

[18]  C. Haynes,et al.  Nanosphere lithography: Tunable localized surface plasmon resonance spectra of silver nanoparticles , 2000 .

[19]  George C. Schatz,et al.  Plasmonic Properties of Copper Nanoparticles Fabricated by Nanosphere Lithography , 2007 .

[20]  Gengfeng Zheng,et al.  Multiplexed electrical detection of cancer markers with nanowire sensor arrays , 2005, Nature Biotechnology.

[21]  H Ballentine Carter,et al.  Prostate cancers in men with low PSA levels--must we find them? , 2004, The New England journal of medicine.

[22]  Joel K. W. Yang,et al.  Graphoepitaxy of Self-Assembled Block Copolymers on Two-Dimensional Periodic Patterned Templates , 2008, Science.

[23]  Bong Hoon Kim,et al.  Hierarchical Self‐Assembly of Block Copolymers for Lithography‐Free Nanopatterning , 2008 .

[24]  Bong Hoon Kim,et al.  One-Dimensional Nanoassembly of Block Copolymers Tailored by Chemically Patterned Surfaces , 2009 .

[25]  Erin M. Lennon,et al.  Evolution of Block Copolymer Lithography to Highly Ordered Square Arrays , 2008, Science.

[26]  Ying Zhang,et al.  Polymer self assembly in semiconductor microelectronics , 2006, 2006 International Electron Devices Meeting.

[27]  H. Solak,et al.  Novel Complex Nanostructure from Directed Assembly of Block Copolymers on Incommensurate Surface Patterns , 2007 .

[28]  G. Schatz.  Theoretical Studies of Surface Enhanced Raman Scattering , 1984 .

[29]  Zhe Yuan,et al.  Plasmonic properties of supported Pt and Pd nanostructures. , 2006, Nano letters.

[30]  W. P. Hall,et al.  A Localized Surface Plasmon Resonance Biosensor: First Steps toward an Assay for Alzheimer's Disease , 2004 .

[31]  Georg Bauer,et al.  Metal Nano-Cluster Biosensors , 1999 .

[32]  S. Chou,et al.  Imprint Lithography with 25-Nanometer Resolution , 1996, Science.

[33]  G. Craig,et al.  Preparation of Neutral Wetting Brushes for Block Copolymer Films from Homopolymer Blends , 2008 .

[34]  Louis E. Brus,et al.  Surface Enhanced Raman Spectroscopy of Individual Rhodamine 6G Molecules on Large Ag Nanocrystals , 1999 .

[35]  R. V. Van Duyne,et al.  Localized surface plasmon resonance spectroscopy and sensing. , 2007, Annual review of physical chemistry.

[36]  Christopher Harrison,et al.  Block copolymer lithography: Periodic arrays of ~1011 holes in 1 square centimeter , 1997 .

[37]  Z. Kam,et al.  Absorption and Scattering of Light by Small Particles , 1998 .

[38]  George C Schatz,et al.  Controlling plasmon line shapes through diffractive coupling in linear arrays of cylindrical nanoparticles fabricated by electron beam lithography. , 2005, Nano letters.

[39]  Jorge E. Fernandez,et al.  Mathematical Modelling of 3D Electron-Photon Transport in Microbeam Analysis , 2000, Microchimica Acta.

[40]  Wonjoon Jung,et al.  Nanofabricated concentric ring structures by templated self-assembly of a diblock copolymer. , 2008, Nano letters.