Metal Based Imaging Probes of DO3A-Act-Met for LAT1 Mediated Methionine Specific Tumors : Synthesis and Preclinical Evaluation

[1]  A. Mishra,et al.  Preclinical evaluation of DO3A-Act-AQ: a polyazamacrocyclic monomeric anthraquinone derivative as a theranostic agent. , 2014, Molecular pharmaceutics.

[2]  Ganghua Tang,et al.  Radiosynthesis and biological evaluation of 5-(3-[18F]fluoropropyloxy)-L-tryptophan for tumor PET imaging. , 2013, Nuclear medicine and biology.

[3]  L. Helm,et al.  Relaxivity of gadolinium (III) complexes: theory and mechanism , 2013 .

[4]  J. Leppänen,et al.  Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion. , 2013, European Journal of Pharmaceutical Sciences.

[5]  A. Karlström,et al.  Influence of DOTA chelator position on biodistribution and targeting properties of (111)In-labeled synthetic anti-HER2 affibody molecules. , 2012, Bioconjugate chemistry.

[6]  Donald D. Nolting,et al.  Molecular imaging probe development: a chemistry perspective. , 2012, American journal of nuclear medicine and molecular imaging.

[7]  Young Joo Kim,et al.  Evaluation of (111)In-labeled macrocyclic chelator-amino acid derivatives for cancer imaging. , 2012, Nuclear medicine and biology.

[8]  A. Mishra,et al.  Preclinical evaluation of DO3P-AME-DO3P: a polyazamacrocyclic methylene phosphonate for diagnosis and therapy of skeletal metastases. , 2011, Bioconjugate chemistry.

[9]  A. Mishra,et al.  Synthesis of specific SPECT-radiopharmaceutical for tumor imaging based on methionine: 99mTc-DTPA-bis(methionine). , 2010, Bioconjugate chemistry.

[10]  M. Yliperttula,et al.  Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[11]  Luis M. De Leon-Rodriguez,et al.  The synthesis and chelation chemistry of DOTA-peptide conjugates. , 2008, Bioconjugate chemistry.

[12]  A. Perkins,et al.  Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer. , 2007, Bioconjugate chemistry.

[13]  H. Nawashiro,et al.  L‐type amino acid transporter 1 as a potential molecular target in human astrocytic tumors , 2006, International journal of cancer.

[14]  B. Fuchs,et al.  Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? , 2005, Seminars in cancer biology.

[15]  Y. Kanai,et al.  Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. , 2005, Cancer letters.

[16]  Susan Morrissey,et al.  TARGETING CANCER: NCI launches initiative to enlist nanotechnology in fight against cancer , 2004 .

[17]  D. Parker,et al.  Poly(l-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging. , 2003, Bioconjugate chemistry.

[18]  Karl Herholz,et al.  Methyl-[11C]-l-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with glioma , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[19]  Y. Kanai,et al.  Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. , 2002, Molecular pharmacology.

[20]  Y. Kanai,et al.  Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. , 2001, Current drug metabolism.

[21]  Y. Kanai,et al.  Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. , 2001, Biochimica et biophysica acta.

[22]  A. Alavi,et al.  Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[23]  J. Bradshaw,et al.  Synthesis of Azacrown Macrocycles and Related Compounds by a Crablike Cyclization Method: A Short Review , 2000 .

[24]  D. Groshar,et al.  FDG-PET Imaging in Small Cell Lung Cancer. , 1999, Clinical positron imaging : official journal of the Institute for Clinical P.E.T.

[25]  W. Goddard,et al.  Mechanism and Energetics for Complexation of 90Y with 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid (DOTA), a Model for Cancer Radioimmunotherapy , 1999 .

[26]  Eiji Takeda,et al.  Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)* , 1998, The Journal of Biological Chemistry.

[27]  E. Bovens,et al.  Multinuclear magnetic resonance study on the structure and dynamics of lanthanide(III) complexes of cyclic DTPA derivatives in aqueous solution , 1996 .

[28]  J. Barbet,et al.  Preliminary study of the metal binding site of an anti-DTPA-indium antibody by equilibrium binding immunoassays and immobilized metal ion affinity chromatography. , 1995, Bioconjugate chemistry.

[29]  U Ruotsalainen,et al.  Carbon-11-methionine and PET is an effective method to image head and neck cancer. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[30]  K. Någren,et al.  Uptake of 11C-methionine in breast cancer studied by PET. An association with the size of S-phase fraction. , 1991, British Journal of Cancer.

[31]  P. Frost,et al.  Biochemical analysis of the role of transmethylation in the methionine dependence of tumor cells. , 1989, Cancer research.

[32]  S. H. Koenig,et al.  Synthesis and Characterization of the Gadolinium(3+) Complex of DOTA-Propylamide: A Model DOTA-Protein Conjugate , 1989 .

[33]  M. Saier,et al.  Neutral amino acid transport systems in animal cells: Potential targets of oncogene action and regulators of cellular growth , 1988, The Journal of Membrane Biology.

[34]  D. Rowitch,et al.  The metabolic defect of methionine dependence occurs frequently in human tumor cell lines. , 1983, Biochemical and biophysical research communications.

[35]  M. Goodenow,et al.  Methionine requirement and replacement by homocysteine in tissue cultures of selected rodent and human malignant and normal cells. , 1978, Cancer research.

[36]  D. Oxender,et al.  Evidence for two Types of Mediation of Neutral Amino-Acid Transport in Ehrlich Cells , 1963, Nature.

[37]  W. Nyhan,et al.  The uptake of a variety of amino acids into nuclear proteins of tumors and other tissues. , 1959, Cancer research.

[38]  J. Mukherjee,et al.  11C-l-Methionine Positron Emission Tomography in the Clinical Management of Cerebral Gliomas , 2007, Molecular Imaging and Biology.

[39]  S. Larson,et al.  Prognostic value of [18F]FDG-PET imaging in small cell lung cancer , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[40]  R. Hoffman Altered methionine metabolism and transmethylation in cancer. , 1985, Anticancer research.