Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
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V. Haucke | A. Echard | A. Bolino | G. Patiño-López | Francina Langa-Vives | K. Klinkert | Linda Sawade | F. Grandi | Roberta Di Guardo | Marianna Mignanelli | F. Langa-Vives
[1] A. Mégarbané,et al. A multicenter retrospective study of charcot‐marie‐tooth disease type 4B (CMT4B) associated with mutations in myotubularin‐related proteins (MTMRs) , 2019, Annals of neurology.
[2] Rongguang Zhang,et al. Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase. , 2019, Structure.
[3] P. Pandolfi,et al. The functions and regulation of the PTEN tumour suppressor: new modes and prospects , 2018, Nature Reviews Molecular Cell Biology.
[4] B. Neumann,et al. A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration , 2018, Nature Communications.
[5] U. Suter,et al. Myelination and mTOR , 2017, Glia.
[6] N. Pedersen,et al. PtdIns3P controls mTORC1 signaling through lysosomal positioning , 2017, The Journal of cell biology.
[7] D. Pareyson,et al. New developments in Charcot–Marie–Tooth neuropathy and related diseases , 2017, Current opinion in neurology.
[8] Jun Du,et al. Folliculin Interacts with Rab35 to Regulate EGF-Induced EGFR Degradation , 2017, Front. Pharmacol..
[9] U. Suter,et al. Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. , 2017 .
[10] J. Milbrandt,et al. mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells , 2017, Proceedings of the National Academy of Sciences.
[11] A. Houdusse,et al. Emerging roles of MICAL family proteins – from actin oxidation to membrane trafficking during cytokinesis , 2017, Journal of Cell Science.
[12] Paul Beckett,et al. Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. , 2017, Blood.
[13] A. Houdusse,et al. Oxidation of F-actin controls the terminal steps of cytokinesis , 2017, Nature Communications.
[14] C. Brombin,et al. Niacin‐mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination , 2016, EMBO molecular medicine.
[15] A. Echard,et al. Rab35 GTPase: A Central Regulator of Phosphoinositides and F‐actin in Endocytic Recycling and Beyond , 2016, Traffic.
[16] J. Salzer,et al. Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS , 2016, The Journal of Neuroscience.
[17] A. Houdusse,et al. Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening , 2016, Nature Communications.
[18] M. Meisler,et al. PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms , 2016, eLife.
[19] V. Haucke,et al. Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic , 2016, The EMBO journal.
[20] V. Haucke,et al. A phosphoinositide conversion mechanism for exit from endosomes , 2016, Nature.
[21] D. Perrais,et al. Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes , 2016, Current Biology.
[22] D. Sabatini,et al. Identification of an oncogenic RAB protein , 2015, Science.
[23] H. Sakagami,et al. Arf6 mediates Schwann cell differentiation and myelination. , 2015, Biochemical and biophysical research communications.
[24] Jean-Pierre Marquette,et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. , 2014, Nature chemical biology.
[25] S. Munro,et al. Toward a Comprehensive Map of the Effectors of Rab GTPases , 2014, Developmental cell.
[26] C. Wessig,et al. mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells. , 2014, Cell reports.
[27] Michael J. Munson,et al. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase , 2014, The Biochemical journal.
[28] A. Tanoue,et al. Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination , 2014, Molecular biology of the cell.
[29] G. Tevzadze,et al. Roles for PI(3,5)P2 in nutrient sensing through TORC1 , 2014, Molecular biology of the cell.
[30] P. McPherson,et al. Rab35: GEFs, GAPs and Effectors , 2013, Traffic.
[31] P. McPherson,et al. Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration , 2013, Journal of Cell Science.
[32] T. Blundell,et al. Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer , 2012, Open Biology.
[33] K. Inoki,et al. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1 , 2012, Molecular biology of the cell.
[34] M. Fukuda,et al. Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth , 2012, Journal of Cell Science.
[35] M. Groszer,et al. Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy , 2012, EMBO molecular medicine.
[36] Brian Burke,et al. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells , 2012, The Journal of cell biology.
[37] K. Nave,et al. Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR , 2012, The Journal of Neuroscience.
[38] B. Goud,et al. An ARF6/Rab35 GTPase Cascade for Endocytic Recycling and Successful Cytokinesis , 2012, Current Biology.
[39] P. McPherson,et al. Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton , 2012, Molecular biology of the cell.
[40] N. Naslavsky,et al. MICAL‐L1 is a Tubular Endosomal Membrane Hub that Connects Rab35 and Arf6 With Rab8a , 2012, Traffic.
[41] M. Meisler,et al. Genetic Interaction between MTMR2 and FIG4 Phospholipid Phosphatases Involved in Charcot-Marie-Tooth Neuropathies , 2011, PLoS genetics.
[42] E. Formstecher,et al. Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis , 2011, Nature Cell Biology.
[43] P. Verstreken,et al. Loss of Skywalker Reveals Synaptic Endosomes as Sorting Stations for Synaptic Vesicle Proteins , 2011, Cell.
[44] W. Möbius,et al. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C , 2010, The Journal of cell biology.
[45] P. McPherson,et al. The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes. , 2010, Molecular cell.
[46] M. Scott,et al. Rab35 Controls Actin Bundling by Recruiting Fascin as an Effector Protein , 2009, Science.
[47] A. Chishti,et al. Dlg1, Sec8, and Mtmr2 Regulate Membrane Homeostasis in Schwann Cell Myelination , 2009, The Journal of Neuroscience.
[48] J. Dixon,et al. Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot–Marie–Tooth 4B2-like peripheral neuropathy in mice , 2008, Proceedings of the National Academy of Sciences.
[49] C. Wessig,et al. Mtmr13/Sbf2-deficient mice: an animal model for CMT4B2. , 2007, Human molecular genetics.
[50] A. Quattrini,et al. Charcot–Marie–Tooth type 4B demyelinating neuropathy: deciphering the role of MTMR phosphatases , 2007, Expert Reviews in Molecular Medicine.
[51] U. Suter,et al. Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. , 2006, Human molecular genetics.
[52] L. Wrabetz,et al. Loss of Mtmr2 Phosphatase in Schwann Cells But Not in Motor Neurons Causes Charcot-Marie-Tooth Type 4B1 Neuropathy with Myelin Outfoldings , 2005, The Journal of Neuroscience.
[53] J. Dixon,et al. The Phosphoinositide-3-phosphatase MTMR2 Associates with MTMR13, a Membrane-associated Pseudophosphatase Also Mutated in Type 4B Charcot-Marie-Tooth Disease* , 2005, Journal of Biological Chemistry.
[54] L. Wrabetz,et al. Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis , 2004, The Journal of cell biology.
[55] R. Ravazzolo,et al. Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma. , 2003, American journal of human genetics.
[56] K. Zerres,et al. Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15. , 2003, Human molecular genetics.
[57] U. Suter,et al. Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1. , 2002, Human molecular genetics.
[58] Soo-A Kim,et al. Myotubularin and MTMR2, Phosphatidylinositol 3-Phosphatases Mutated in Myotubular Myopathy and Type 4B Charcot-Marie-Tooth Disease* , 2002, The Journal of Biological Chemistry.
[59] Aldo Quattrone,et al. Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2 , 2000, Nature Genetics.
[60] L. Wrabetz,et al. P0‐Cre Transgenic Mice for Inactivation of Adhesion Molecules in Schwann Cells , 1999, Annals of the New York Academy of Sciences.
[61] C. Taveggia,et al. DRG Neuron/Schwann Cells Myelinating Cocultures. , 2018, Methods in molecular biology.
[62] S. Friant,et al. WANTED - Dead or alive: Myotubularins, a large disease-associated protein family. , 2017, Advances in biological regulation.
[63] S. Holm. A Simple Sequentially Rejective Multiple Test Procedure , 1979 .
[64] C. Wessig,et al. mTORC 1 Controls PNS Myelination along the mTORC 1-RXR gamma-SREBP-Lipid Biosynthesis Axis in Schwann Cells , 2022 .