Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.
暂无分享,去创建一个
C. Kahn | G. King | M. Yanagisawa | K. Suzuma | M. Holzenberger | D. Vicent | Tatsuya Kondo | George L. King | C. Kahn
[1] C. Kahn,et al. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. , 2003, The Journal of clinical investigation.
[2] D. Pinsky,et al. Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction , 2002, Current opinion in critical care.
[3] G. Yancopoulos,et al. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. , 2002, The Journal of clinical investigation.
[4] T. Hamanaka,et al. Retinal ischemia and angle neovascularization in proliferative diabetic retinopathy. , 2001, American journal of ophthalmology.
[5] J. Chiu,et al. Endothelial exposure to hypoxia induces Egr‐1 expression involving PKCα‐mediated Ras/Raf‐1/ERK1/2 pathway , 2001, Journal of cellular physiology.
[6] R. Higgins,et al. Captopril improves retinal neovascularization via endothelin-1. , 2001, Investigative Ophthalmology and Visual Science.
[7] R K Jain,et al. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[8] G. Taraboletti,et al. Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. , 2000, The American journal of pathology.
[9] N. Vaziri,et al. Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression. , 2000, American journal of physiology. Endocrinology and metabolism.
[10] M. Shichiri,et al. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. , 2000, Diabetes care.
[11] G. Semenza. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. , 2000, Journal of applied physiology.
[12] G. King,et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. , 2000, Circulation.
[13] P. Campochiaro,et al. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. , 2000, The American journal of pathology.
[14] A. Zeiher,et al. Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. , 2000, Arteriosclerosis, thrombosis, and vascular biology.
[15] Lois E. H. Smith,et al. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor , 1999, Nature Medicine.
[16] A. Adamis,et al. Insulin-induced vascular endothelial growth factor expression in retina. , 1999, Investigative ophthalmology & visual science.
[17] T. Fujimori,et al. Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR. , 1999, Hypertension.
[18] Alan W. Stitt,et al. Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia. , 1999, Biochemical and biophysical research communications.
[19] M. Quon,et al. Insulin stimulates both endothelin and nitric oxide activity in the human forearm. , 1999, Circulation.
[20] D. Silver,et al. Changes in free insulin-like growth factor-1 and leptin concentrations during acute metabolic decompensation in insulin withdrawn patients with type 1 diabetes. , 1999, The Journal of clinical endocrinology and metabolism.
[21] Y. Zou,et al. Hypoxia-associated Induction of Early Growth Response-1 Gene Expression* , 1999, The Journal of Biological Chemistry.
[22] J. Cunha-Vaz. Lowering the risk of visual impairment and blindness , 1998, Diabetic medicine : a journal of the British Diabetic Association.
[23] G. King,et al. Protein kinase C activation and the development of diabetic complications. , 1998, Diabetes.
[24] A. Akaike,et al. Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina. , 1998, European journal of pharmacology.
[25] J. Stone,et al. Mechanisms of retinal angiogenesis , 1997, Progress in Retinal and Eye Research.
[26] L. Aiello,et al. Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. , 1997, Diabetes/metabolism reviews.
[27] L. Groop,et al. The Effect of Glycaemic Control and the Introduction of Insulin Therapy on Retinopathy in Non‐insulin‐dependent Diabetes Mellitus , 1997, Diabetic medicine : a journal of the British Diabetic Association.
[28] G. Desideri,et al. Effect of ACE Inhibition on Spontaneous and Insulin-Stimulated Endothelin-1 Secretion: In Vitro and In Vivo Studies , 1997, Diabetes.
[29] G. Katzman. Retinopathy of prematurity: is suppression of neovascularization achievable? , 1996, Jornal de Pediatria.
[30] S. Bursell,et al. Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia. , 1996, Investigative ophthalmology & visual science.
[31] G. Lutty,et al. Localization of vascular endothelial growth factor in human retina and choroid. , 1996, Archives of ophthalmology.
[32] M. White,et al. Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase , 1996, Molecular and cellular biology.
[33] D. S. Mcleod,et al. Vaso-obliteration in the canine model of oxygen-induced retinopathy. , 1996, Investigative ophthalmology & visual science.
[34] L. Aiello,et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. , 1994, The New England journal of medicine.
[35] J. Blenis,et al. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation , 1994, Molecular and cellular biology.
[36] R. Dash,et al. Effect of insulin therapy on progression of retinopathy in noninsulin-dependent diabetes mellitus. , 1993, American journal of ophthalmology.
[37] M. Yacoub,et al. Antigenic heterogeneity of vascular endothelium. , 1992, The American journal of pathology.
[38] M. Loeken,et al. Stimulation of endothelin-1 gene expression by insulin in endothelial cells. , 1991, The Journal of biological chemistry.
[39] S Moncada,et al. Role of endothelium-derived nitric oxide in the regulation of blood pressure. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[40] T. Deckert,et al. Two-Year Experience with Continuous Subcutaneous Insulin Infusion in Relation to Retinopathy and Neuropathy , 1985, Diabetes.
[41] K. Dahl-Jørgensen,et al. Rapid tightening of blood glucose control leads to transient deterioration of retinopathy in insulin dependent diabetes mellitus: the Oslo study. , 1985, British medical journal.
[42] P. Huang,et al. Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice. , 2001, Investigative ophthalmology & visual science.
[43] T. Sano,et al. [Diabetic retinopathy]. , 2001, Nihon rinsho. Japanese journal of clinical medicine.
[44] A. Dembińska-kieć,et al. Nitric oxide mediates the mitogenic effects of insulin and vascular endothelial growth factor but not of leptin in endothelial cells. , 1999, Acta biochimica Polonica.
[45] R. Klein,et al. The 14-year incidence of visual loss in a diabetic population. , 1998, Ophthalmology.
[46] Lois E. H. Smith,et al. Oxygen-induced retinopathy in the mouse. , 1994, Investigative ophthalmology & visual science.
[47] F. Murad,et al. The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues. , 1992, Japanese journal of pharmacology.