Mitochondrial oxygen consumption rate of human embryos declines with maternal age

[1]  L. Rienzi,et al.  Impact of Maternal Age on Oocyte and Embryo Competence , 2018, Front. Endocrinol..

[2]  David K. Gardner,et al.  Handbook of In Vitro Fertilization , 2017 .

[3]  Y. Morimoto,et al.  Quantitative and qualitative changes of mitochondria in human preimplantation embryos , 2017, Journal of Assisted Reproduction and Genetics.

[4]  Y. Morimoto,et al.  Multinucleation per se is not sufficient as a marker of abnormality to decide against transferring human embryos generated in vitro , 2016 .

[5]  Y. Morimoto,et al.  Multinucleation per se is not always sufficient as a marker of abnormality to decide against transferring human embryos. , 2016, Fertility and sterility.

[6]  A. Diez-Juan,et al.  Mitochondrial DNA content as a viability score in human euploid embryos: less is better. , 2015, Fertility and sterility.

[7]  T. Kitajima,et al.  Bivalent separation into univalents precedes age-related meiosis I errors in oocytes , 2015, Nature Communications.

[8]  F. Kokocinski,et al.  Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential , 2015, PLoS genetics.

[9]  Huanming Yang,et al.  Clinical outcome of preimplantation genetic diagnosis and screening using next generation sequencing , 2014, GigaScience.

[10]  Y. Morimoto,et al.  Possible selection of viable human blastocysts after vitrification by monitoring morphological changes , 2014, Journal of Assisted Reproduction and Genetics.

[11]  Y. Yoshimura,et al.  Embryo developmental capability and pregnancy outcome are related to the mitochondrial DNA copy number and ooplasmic volume , 2013, Journal of Assisted Reproduction and Genetics.

[12]  Patricia A. Hunt,et al.  Human aneuploidy: mechanisms and new insights into an age-old problem , 2012, Nature Reviews Genetics.

[13]  Yoshiharu Morimoto,et al.  Selection of high-potential embryos by culture in poly(dimethylsiloxane) microwells and time-lapse imaging. , 2012, Fertility and sterility.

[14]  Y. Morimoto,et al.  Developmental assessment of human vitrified-warmed blastocysts based on oxygen consumption. , 2011, Human reproduction.

[15]  J. Blerkom.  Mitochondrial function in the human oocyte and embryo and their role in developmental competence. , 2011 .

[16]  R. Casper,et al.  The contribution of mitochondrial function to reproductive aging , 2011, Journal of Assisted Reproduction and Genetics.

[17]  S. Lindenberg,et al.  Murine pre-embryo oxygen consumption and developmental competence , 2007, Journal of Assisted Reproduction and Genetics.

[18]  D. Gardner,et al.  Embryo Culture Systems , 2006 .

[19]  P. Ho,et al.  Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes. , 2005, Molecular human reproduction.

[20]  P. Reynier,et al.  Low oocyte mitochondrial DNA content in ovarian insufficiency. , 2005, Human reproduction.

[21]  Hitoshi Shiku,et al.  Respiration activity of single bovine embryos entrapped in a cone-shaped microwell monitored by scanning electrochemical microscopy , 2004 .

[22]  R. Ferriani,et al.  Why Do Older Women Have Poor Implantation Rates? A Possible Role of the Mitochondria , 2004, Journal of Assisted Reproduction and Genetics.

[23]  H. Leese.  Quiet please, do not disturb: a hypothesis of embryo metabolism and viability. , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[24]  A. Trounson,et al.  Mitochondrial morphology during preimplantational human embryogenesis. , 2000, Human reproduction.

[25]  D M Porterfield,et al.  Oxidative Phosphorylation-Dependent and -Independent Oxygen Consumption by Individual Preimplantation Mouse Embryos1 , 2000, Biology of reproduction.

[26]  T. Strowitzki,et al.  Morphological-cytochemical and molecular genetic analyses of mitochondria in isolated human oocytes in the reproductive age. , 1996, Molecular human reproduction.

[27]  J. G. Thompson,et al.  Oxygen uptake and carbohydrate metabolism by in vitro derived bovine embryos. , 1996, Journal of reproduction and fertility.

[28]  B. Ames,et al.  Oxidative damage and mitochondrial decay in aging. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[29]  A. J. Watson,et al.  The cell biology of blastocyst development , 1992, Molecular reproduction and development.

[30]  L. Nilsson,et al.  Oxygen consumption by human oocytes and blastocysts grown in vitro. , 1986, Human reproduction.

[31]  D. Griffin,et al.  Accurate quantitation of mitochondrial DNA reveals uniform levels in human blastocysts irrespective of ploidy, age, or implantation potential. , 2017, Fertility and sterility.

[32]  G. Vajta,et al.  Comparison of open and closed methods for vitrification of human embryos and the elimination of potential contamination. , 2005, Reproductive biomedicine online.

[33]  C. Racowsky,et al.  The development of fertilized human ova to the blastocyst stage in KSOM(AA) medium: is a two-step protocol necessary? , 2002, Reproductive biomedicine online.