Role of whey proteins in combating geriatric disorders

Ageing in humans is usually accompanied by deterioration in physical fitness and increased susceptibility to disease, adding to the economic burden of the person concerned. Inadequate food intake, reduced desire to eat, decline in food digestion or absorption, compromise in nutritional metabolic pathways, poor dental hygiene or preponderance of chronic diseases, which are commonly found in the elderly, can lead to an increased risk of under-nutrition. Adequate dietary nutrition has an undisputed role in healthy ageing. Among the various nutrients, proteins play an important role in geriatric health. This review emphasizes the nutritional aspects of milk-based whey proteins and their role in tackling health problems in the geriatric population. Nutritionally rich whey protein constituents such as β-lactoglobulin, α-lactalbumin, bovine serum albumin, lactoferrin and proteose peptone have all been reported to have a plethora of functional roles in various biological processes and organ systems in geriatrics and thus help in the management of geriatric health problems through proper nutrition. © 2013 Society of Chemical Industry

[1]  P. Wade,et al.  Aging and neural control of the GI tract. I. Age-related changes in the enteric nervous system. , 2002, American journal of physiology. Gastrointestinal and liver physiology.

[2]  A. Pihlanto-Leppälä Bioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides. , 2000 .

[3]  T. Akhavan,et al.  Whey Proteins in the Regulation of Food Intake and Satiety , 2007, Journal of the American College of Nutrition.

[4]  G. Boss,et al.  Age-related physiological changes and their clinical significance. , 1981, The Western journal of medicine.

[5]  J. Steijns Milk ingredients as nutraceuticals , 2001 .

[6]  R. Chernoff Protein and Older Adults , 2004, Journal of the American College of Nutrition.

[7]  Alberto Radaelli,et al.  Invited review: aging and the cardiovascular system. , 2003, Journal of applied physiology.

[8]  Michael J Falvo,et al.  Protein - Which is Best? , 2004, Journal of sports science & medicine.

[9]  M. Zemel,et al.  Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review). , 2003, The Journal of nutritional biochemistry.

[10]  H. Gill,et al.  Anticancer properties of bovine milk , 2000, British Journal of Nutrition.

[11]  N. Shah Effects of milk-derived bioactives: an overview , 2000, British Journal of Nutrition.

[12]  G. Bounous Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. , 2000, Anticancer research.

[13]  D. Walsh,et al.  Hypotensive peptides from milk proteins. , 2004, The Journal of nutrition.

[14]  G. Bounous,et al.  The antioxidant system. , 2003, Anticancer research.

[15]  M. El-Loly,et al.  Lactoferrin in Relation to Biological Functions and Applications: A Review , 2011 .

[16]  Nils Roos,et al.  Bioactive peptides and proteins from foods: indication for health effects , 2008, European journal of nutrition.

[17]  J. Rosa,et al.  Dietary whey protein lessens several risk factors for metabolic diseases: a review , 2012, Lipids in Health and Disease.

[18]  J. Bisognano,et al.  Hypertension in the very elderly: Brief review of management. , 2009, Cardiology journal.

[19]  E. Richter,et al.  Regulatory mechanisms of skeletal muscle protein turnover during exercise. , 2009, Journal of applied physiology.

[20]  A. Avenell,et al.  Interventions to achieve long-term weight loss in obese older people: a systematic review and meta-analysis. , 2010, Age and ageing.

[21]  A. Byszewski,et al.  Non-pharmacological management of primary and secondary insomnia among older people: review of assessment tools and treatments. , 2003, Age and ageing.

[22]  M. García‐Garibay,et al.  Whey Proteins: Bioengineering and Health , 2008 .

[23]  S. Lord,et al.  Physiological Factors Associated with Falls in Older Community‐Dwelling Women , 1994, Journal of the American Geriatrics Society.

[24]  J. Holst,et al.  Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks. , 2007, The American journal of clinical nutrition.

[25]  R. Wolfe,et al.  Role of dietary protein in the sarcopenia of aging. , 2008, The American journal of clinical nutrition.

[26]  Hao Zhang,et al.  Orally administered lactoferrin preserves bone mass and microarchitecture in ovariectomized rats. , 2009, The Journal of nutrition.

[27]  R. Wolfe,et al.  Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein , 2006, Experimental Gerontology.

[28]  B. Beaufrère,et al.  Influence of the protein digestion rate on protein turnover in young and elderly subjects. , 2002, The Journal of nutrition.

[29]  G. Krissansen,et al.  Emerging Health Properties of Whey Proteins and Their Clinical Implications , 2007, Journal of the American College of Nutrition.

[30]  S. Sindayikengera,et al.  Nutritional evaluation of caseins and whey proteins and their hydrolysates from Protamex , 2006, Journal of Zhejiang University SCIENCE B.

[31]  B. Stoll,et al.  Nutritional and functional importance of intestinal sulfur amino acid metabolism. , 2005, The Journal of nutrition.

[32]  E. Favaloro,et al.  Potential benefits of improved protein intake in older people , 2008 .

[33]  D. Chinkes,et al.  Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. , 2008, Nutrition research.

[34]  R. Wolfe,et al.  Optimal protein intake in the elderly. , 2008, Clinical nutrition.

[35]  M. Jafferany,et al.  Geriatric dermatoses: a clinical review of skin diseases in an aging population , 2012, International journal of dermatology.

[36]  S. Fujita,et al.  Amino acids and muscle loss with aging. , 2006, The Journal of nutrition.

[37]  E. Offord,et al.  Lactoferrin reduces in vitro osteoclast differentiation and resorbing activity. , 2002, Biochemical and biophysical research communications.

[38]  M. Hussein,et al.  The Effect of Natural Formulated Functional Biscuits on Elderly Bone Health , 2006 .

[39]  A. Alsaif,et al.  The Nutritional, Glutathione and Oxidant Status of Elderly Subjects Admitted to a University Hospital , 2011, Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.

[40]  E. Foegeding,et al.  Advances in modifying and understanding whey protein functionality , 2002 .

[41]  P. Koskinen,et al.  Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. , 2000, The Journal of dairy research.

[42]  O. Ljungqvist,et al.  Nutritional status, well-being and functional ability in frail elderly service flat residents , 2005, European Journal of Clinical Nutrition.

[43]  J. Girardet,et al.  Biologically active factors in bovine milk and dairy byproducts: influence on cell culture. , 1997, Critical reviews in food science and nutrition.

[44]  E. Brody,et al.  Biological activities of bovine glycomacropeptide , 2000, British Journal of Nutrition.

[45]  B. Lesourd,et al.  Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. , 1997, The American journal of clinical nutrition.

[46]  D. Kiel,et al.  Effect of Dietary Protein on Bone Loss in Elderly Men and Women: The Framingham Osteoporosis Study , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[47]  E. Burns,et al.  Effects of aging on immune function. , 2004, The journal of nutrition, health & aging.

[48]  S. Fujita,et al.  Muscle tissue changes with aging , 2004, Current opinion in clinical nutrition and metabolic care.

[49]  M. Woodward Managing Insomnia in Older People , 2007 .

[50]  J. Holst,et al.  Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects. , 2005, The American journal of clinical nutrition.

[51]  Clifford Qualls,et al.  Weight loss, exercise, or both and physical function in obese older adults. , 2011, The New England journal of medicine.

[52]  Manuela E. Pintado,et al.  Bovine whey proteins – Overview on their main biological properties , 2007, Food Research International.

[53]  C. Guillén,et al.  The effects of local administration of lactoferrin on inflammation in murine autoimmune and infectious arthritis. , 2000, Arthritis and rheumatism.

[54]  W. Evans,et al.  Sarcopenia and age-related changes in body composition and functional capacity. , 1993, The Journal of nutrition.

[55]  Luigi Ferrucci,et al.  Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. , 2003, Journal of applied physiology.

[56]  R. Wolfe,et al.  Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. , 2003, The American journal of clinical nutrition.

[57]  J. Morley,et al.  The clinical significance of gastrointestinal changes with aging , 2008, Current opinion in clinical nutrition and metabolic care.

[58]  M. Etzel,et al.  Manufacture and use of dairy protein fractions. , 2004, The Journal of nutrition.

[59]  D. Tomé,et al.  Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal health. , 2008, The American journal of clinical nutrition.

[60]  J. H. Chung,et al.  Aging- and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo. , 2001, The Journal of investigative dermatology.

[61]  P. Lemon Beyond the Zone: Protein Needs of Active Individuals , 2000, Journal of the American College of Nutrition.

[62]  K. Nair,et al.  Diabetes in old age: an emerging epidemic. , 2003, The Journal of the Association of Physicians of India.

[63]  H. Kawakami Biological Significance of Milk Basic Protein (MBP) for Bone Health , 2005 .

[64]  R. Russell,et al.  Changes in gastrointestinal function attributed to aging. , 1992, The American journal of clinical nutrition.

[65]  V. Lushchak,et al.  Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions , 2012, Journal of amino acids.

[66]  R. Wolfe,et al.  Amino acid ingestion improves muscle protein synthesis in the young and elderly. , 2004, American journal of physiology. Endocrinology and metabolism.

[67]  Hiroyuki Tsuda,et al.  Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies. , 2002, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[68]  S. Kimball,et al.  Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. , 2001, The Journal of nutrition.

[69]  Hosam K Kamel,et al.  Sarcopenia and aging. , 2003, Nutrition reviews.

[70]  Edward N Baker,et al.  Lactoferrin Is a Potent Regulator of Bone Cell Activity and Increases Bone Formation in Vivo , 2022 .

[71]  Geoffrey W. Smithers,et al.  Whey and whey proteins-From 'gutter-to-gold' , 2008 .

[72]  L. Rodrigues,et al.  Lactoferrin and Cancer Disease Prevention , 2008, Critical reviews in food science and nutrition.

[73]  M. Laakso,et al.  Prevalence of Diabetes and Impaired Glucose Tolerance in Elderly Subjects and Their Association With Obesity and Family History of Diabete , 1990, Diabetes Care.

[74]  I. Rieu,et al.  Increased availability of leucine with leucine-rich whey proteins improves postprandial muscle protein synthesis in aging rats. , 2007, Nutrition.

[75]  T. B. Symons,et al.  Functional and metabolic consequences of sarcopenia. , 2001, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[76]  K. Charlton Eating well: ageing gracefully! , 2002, Asia Pacific journal of clinical nutrition.

[77]  J. German,et al.  Whey Components: Millennia of Evolution Create Functionalities for Mammalian Nutrition: What We Know and What We May Be Overlooking , 2002, Critical reviews in food science and nutrition.

[78]  H. Kuipers,et al.  Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. , 2011, The American journal of clinical nutrition.