Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes

[1]  Y. Stern-Bach,et al.  Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin , 2017, Neuron.

[2]  D. Agard,et al.  MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy , 2017, Nature Methods.

[3]  C. Landes,et al.  Stargazin Modulation of AMPA Receptors. , 2016, Cell reports.

[4]  M. Kurnikova,et al.  Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs , 2016, Neuron.

[5]  S. Subramaniam,et al.  Structural basis of kainate subtype glutamate receptor desensitization , 2016, Nature.

[6]  E. C. Twomey,et al.  Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy , 2016, Science.

[7]  E. Gouaux,et al.  Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM , 2016, Nature.

[8]  E. Lindahl,et al.  Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2 , 2016, bioRxiv.

[9]  P. Biggin,et al.  Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes , 2016, Neuron.

[10]  K. Roche,et al.  GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons , 2016, Nature Communications.

[11]  L. Wollmuth,et al.  A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors , 2016, The Journal of Neuroscience.

[12]  A. Sobolevsky,et al.  Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors , 2016, Scientific Reports.

[13]  M. Farrant,et al.  Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function , 2015, The Journal of Neuroscience.

[14]  N. Grigorieff,et al.  CTFFIND4: Fast and accurate defocus estimation from electron micrographs , 2015, bioRxiv.

[15]  Guanghui Yang,et al.  Sampling the conformational space of the catalytic subunit of human γ-secretase , 2015, bioRxiv.

[16]  Kai Zhang,et al.  Gctf: Real-time CTF determination and correction , 2015, bioRxiv.

[17]  Bruno Rossion,et al.  Figures and figure supplements , 2014 .

[18]  Nikolaus Grigorieff,et al.  Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6 , 2015, eLife.

[19]  Hiroshi Suzuki,et al.  Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin , 2015, Science.

[20]  Sjors H.W. Scheres,et al.  Semi-automated selection of cryo-EM particles in RELION-1.3 , 2015, Journal of structural biology.

[21]  Lori A. Passmore,et al.  Ultrastable gold substrates for electron cryomicroscopy , 2014, Science.

[22]  S. Ramaswamy,et al.  Stargazin promotes closure of the AMPA receptor ligand-binding domain , 2014, The Journal of general physiology.

[23]  E. Gouaux,et al.  Screening and large-scale expression of membrane proteins in mammalian cells for structural studies , 2014, Nature Protocols.

[24]  A. Sobolevsky,et al.  Structure of an agonist-bound ionotropic glutamate receptor , 2014, Science.

[25]  E. Gouaux,et al.  Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States , 2014, Cell.

[26]  Prashant Rao,et al.  Structural mechanism of glutamate receptor activation and desensitization , 2014, Nature.

[27]  O. Nureki,et al.  Crystal structure of mouse claudin-15 , 2014 .

[28]  Marco Biasini,et al.  SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information , 2014, Nucleic Acids Res..

[29]  O. Nureki,et al.  Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions , 2014, Science.

[30]  E. Hollander,et al.  The Role of Ionotropic Glutamate Receptors in Childhood Neurodevelopmental Disorders: Autism Spectrum Disorders and Fragile X Syndrome , 2014, Current neuropharmacology.

[31]  R. Henderson,et al.  High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy☆ , 2013, Ultramicroscopy.

[32]  Hemant D. Tagare,et al.  The Local Resolution of Cryo-EM Density Maps , 2013, Nature Methods.

[33]  M A Rogawski,et al.  AMPA receptors as a molecular target in epilepsy therapy , 2013, Acta neurologica Scandinavica. Supplementum.

[34]  Sjors H.W. Scheres,et al.  RELION: Implementation of a Bayesian approach to cryo-EM structure determination , 2012, Journal of structural biology.

[35]  Shaoxia Chen,et al.  Prevention of overfitting in cryo-EM structure determination , 2012, Nature Methods.

[36]  J. Yates,et al.  Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L. , 2012, Cell reports.

[37]  A. Plested,et al.  Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors , 2012, Neuron.

[38]  Uwe Schulte,et al.  High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes , 2012, Neuron.

[39]  P. Zwart,et al.  Towards automated crystallographic structure refinement with phenix.refine , 2012, Acta crystallographica. Section D, Biological crystallography.

[40]  L. Nowak,et al.  Mechanisms of Modal Activation of GluA3 Receptors , 2011, Molecular Pharmacology.

[41]  R. Nicoll,et al.  The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits , 2011, Neuron.

[42]  Christy F. Landes,et al.  Structural landscape of the isolated ligand binding domain of single AMPA receptors , 2011, Nature chemical biology.

[43]  R. Dingledine,et al.  Glutamate Receptor Ion Channels: Structure, Regulation, and Function , 2010, Pharmacological Reviews.

[44]  V. Jayaraman,et al.  Role of dimer interface in activation and desensitization in AMPA receptors , 2010, Proceedings of the National Academy of Sciences.

[45]  M. Hayden,et al.  Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis. , 2010, Human molecular genetics.

[46]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[47]  E. Gouaux,et al.  X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor , 2009, Nature.

[48]  M. Mayer,et al.  AMPA Receptor Ligand Binding Domain Mobility Revealed by Functional Cross Linking , 2009, The Journal of Neuroscience.

[49]  Devin K. Schweppe,et al.  A Nondesensitizing Kainate Receptor Point Mutant , 2009, Molecular Pharmacology.

[50]  E. Gouaux,et al.  Crystal structure and association behaviour of the GluR2 amino‐terminal domain , 2009, The EMBO journal.

[51]  D. Bowie Ionotropic glutamate receptors & CNS disorders. , 2008, CNS & neurological disorders drug targets.

[52]  S. Tomita,et al.  Two Families of TARP Isoforms that Have Distinct Effects on the Kinetic Properties of AMPA Receptors and Synaptic Currents , 2007, Neuron.

[53]  Y. Stern-Bach,et al.  Block of Kainate Receptor Desensitization Uncovers a Key Trafficking Checkpoint , 2006, Neuron.

[54]  Christian Rosenmund,et al.  Conformational restriction blocks glutamate receptor desensitization , 2006, Nature Structural &Molecular Biology.

[55]  E. Gouaux,et al.  Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor , 2006, Cell.

[56]  J. Howe,et al.  The relationship between agonist potency and AMPA receptor kinetics. , 2006, Biophysical journal.

[57]  Eric Gouaux,et al.  Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. , 2006, Structure.

[58]  David N Mastronarde,et al.  Automated electron microscope tomography using robust prediction of specimen movements. , 2005, Journal of structural biology.

[59]  Joshua T Dudman,et al.  Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors , 2005, The Journal of Neuroscience.

[60]  Anchi Cheng,et al.  Automated molecular microscopy: the new Leginon system. , 2005, Journal of structural biology.

[61]  H. Adesnik,et al.  Stargazin modulates AMPA receptor gating and trafficking by distinct domains , 2005, Nature.

[62]  J. Gouaux,et al.  AMPA Receptor Binding Cleft Mutations That Alter Affinity, Efficacy, and Recovery from Desensitization , 2005, The Journal of Neuroscience.

[63]  P. Osten,et al.  Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors , 2005, The Journal of Neuroscience.

[64]  M. Sheng,et al.  Structure and different conformational states of native AMPA receptor complexes , 2005, Nature.

[65]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[66]  C. Jatzke,et al.  Block of AMPA Receptor Desensitization by a Point Mutation outside the Ligand-Binding Domain , 2004, The Journal of Neuroscience.

[67]  M. Mayer,et al.  Structural basis for partial agonist action at ionotropic glutamate receptors , 2003, Nature Neuroscience.

[68]  Eng H. Lo,et al.  Neurological diseases: Mechanisms, challenges and opportunities in stroke , 2003, Nature Reviews Neuroscience.

[69]  J. Howe,et al.  How AMPA Receptor Desensitization Depends on Receptor Occupancy , 2003, The Journal of Neuroscience.

[70]  M. Mayer,et al.  Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate. , 2002, Biochemistry.

[71]  M. Mayer,et al.  Mechanism of glutamate receptor desensitization , 2002, Nature.

[72]  Dane M. Chetkovich,et al.  Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms , 2000, Nature.

[73]  Hsiao-Wen Chen,et al.  Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68 , 2000, Nature.

[74]  E. Gouaux,et al.  Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor Crystal Structures of the GluR2 Ligand Binding Core , 2000, Neuron.

[75]  M. Bennett,et al.  Knockdown of AMPA Receptor GluR2 Expression Causes Delayed Neurodegeneration and Increases Damage by Sublethal Ischemia in Hippocampal CA1 and CA3 Neurons , 1999, The Journal of Neuroscience.

[76]  Christian Rosenmund,et al.  A Point Mutation in the Glutamate Binding Site Blocks Desensitization of AMPA Receptors , 1998, Neuron.

[77]  B. Gustafsson,et al.  Ionotropic glutamate receptors , 1996, Molecular Neurobiology.

[78]  P. Seeburg,et al.  RNA editing in brain controls a determinant of ion flow in glutamate-gated channels , 1991, Cell.

[79]  B. Sakmann,et al.  A family of AMPA-selective glutamate receptors. , 1990, Science.

[80]  S. Heinemann,et al.  Cloning by functional expression of a member of the glutamate receptor family , 1989, Nature.

[81]  W. Lu,et al.  GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons. , 2017, Journal of neurophysiology.

[82]  A. Sobolevsky Structure and gating of tetrameric glutamate receptors , 2015, The Journal of physiology.

[83]  张炜 Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors , 2014 .

[84]  Wen Jiang,et al.  EMAN2: an extensible image processing suite for electron microscopy. , 2007, Journal of structural biology.