Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.
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S. Melotto | M. Corsi | D. Montanari | S. Provera | D. Trist | E. Ratti | D. Donati | R. Di Fabio | G. Guercio | Giuseppe S. Alvaro | Cristiana Griffante | Zadeo Cimarosti | P. Gerrard | T. Rossi | Laura Zonzini | C. Marchioro | D. A. Pizzi | M. Mattioli | G. Pentassuglia