Neurogliaform cells dynamically regulate somatosensory integration via synapse-specific modulation

Despite the prevailing idea that neurogliaform cells produce a spatially unrestricted widespread inhibition, we demonstrate here that their activity attenuates thalamic-evoked feed-forward inhibition in layer IV barrel cortex but has no effect on feed-forward excitation. The result of this circuit selectivity is a dynamic regulation in the temporal window for integration of excitatory thalamic input, thus revealing a new role for neurogliaform cells in shaping sensory processing.

[1]  S. Cruikshank,et al.  Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex , 2007, Nature Neuroscience.

[2]  G. Fishell,et al.  The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin Receptors , 2010, The Journal of Neuroscience.

[3]  Csaba Varga,et al.  Regulation of cortical microcircuits by unitary GABAergic volume transmission , 2009, Nature.

[4]  R. Yuste,et al.  The Logic of Inhibitory Connectivity in the Neocortex , 2013, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[5]  B. Fakler,et al.  Native GABAB receptors are heteromultimers with a family of auxiliary subunits , 2010, Nature.

[6]  Ivan Soltesz,et al.  Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast , 2007, Proceedings of the National Academy of Sciences.

[7]  J. Isaac,et al.  Emergence of cortical inhibition by coordinated sensory–driven plasticity at distinct synaptic loci , 2010, Nature Neuroscience.

[8]  M. Capogna,et al.  Neurogliaform cells of amygdala: a source of slow phasic inhibition in the basolateral complex , 2012, The Journal of physiology.

[9]  Y. Yanagawa,et al.  Selective Gating of Glutamatergic Inputs to Excitatory Neurons of Amygdala by Presynaptic GABAb Receptor , 2009, Neuron.

[10]  V. Gallo,et al.  Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons , 2003, The Journal of cell biology.

[11]  G. Tamás,et al.  Identified Sources and Targets of Slow Inhibition in the Neocortex , 2003, Science.

[12]  B. Sakmann,et al.  Cortex Is Driven by Weak but Synchronously Active Thalamocortical Synapses , 2006, Science.

[13]  Matteo Carandini,et al.  Somatosensory Integration Controlled by Dynamic Thalamocortical Feed-Forward Inhibition , 2005, Neuron.

[14]  B. Connors,et al.  Thalamocortical responses of mouse somatosensory (barrel) cortexin vitro , 1991, Neuroscience.

[15]  G. González-Burgos.  GABA transporter GAT1: a crucial determinant of GABAB receptor activation in cortical circuits? , 2010, Advances in pharmacology.

[16]  D. Rusakov,et al.  Slow GABA Transient and Receptor Desensitization Shape Synaptic Responses Evoked by Hippocampal Neurogliaform Cells , 2010, The Journal of Neuroscience.

[17]  S. Anderson,et al.  Fate mapping Nkx2.1‐lineage cells in the mouse telencephalon , 2008, The Journal of comparative neurology.

[18]  S. Biasi,et al.  Expression of GABA transporters, GAT-1 and GAT-3, in the cerebral cortex and thalamus of the rat during postnatal development , 2003, Cell and Tissue Research.